scrib scribble planar cell polarity protein [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: scribprovided by ZNC
Official Full Name: scribble planar cell polarity proteinprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030616-572
See related: Ensembl:ENSDARG00000000861 AllianceGenome:ZFIN:ZDB-GENE-030616-572
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: scrb1; scribble; scribble1; si:zc12p8.1; si:ch211-12p8.1
Summary: Enables protein heterodimerization activity. Acts upstream of or within several processes, including establishment of mitotic spindle orientation; morphogenesis of an epithelium; and nervous system development. Located in membrane. Is expressed in anterior-posterior polarized posterior lateral line neuromast; brain; neural tube; and secondary posterior lateral line primordium. Orthologous to human SCRIB (scribble planar cell polarity protein). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 48

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	7	NC_007118.7 (41159188..41275232)
105	previous assembly	GRCz10 (GCF_000002035.5)	7	NC_007118.6 (40878861..40995161)

Chromosome 7 - NC_007118.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results demonstrate that anterior guidance decisions by commissural primary ascending (CoPA) axons are dependent on the function of planar cell polarity genes Fzd3a, Vangl2 and Scribble both prior to and after midline crossing; experiments establish CoPA axons as a model system to investigate the mechanism of planar cell polarity signaling in commissural axon guidance.
Title: Planar cell polarity genes Frizzled3a, Vangl2, and Scribble are required for spinal commissural axon guidance.
Zygotic expression of Scribble1 (scrb1) is required for migration of the nVII motor neurons mainly in a non cell-autonomous manner, while maternal expression is required for convergent extension movements during gastrulation.
Title: Dual roles of zygotic and maternal Scribble1 in neural migration and convergent extension movements in zebrafish embryos.
Suppression of scrib and puf60 in zebrafish leads to reduction in body length, small head size, and craniofacial defects.
Title: SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant.
It was found that Scribble is required for oriented cell division and that its function in this process is independent of canonical apicobasal and planar polarity pathways.
Title: Zebrafish neural tube morphogenesis requires Scribble-dependent oriented cell divisions.
Scribble is a candidate link between Fat and the Hippo signaling cascade in vertebrates
Title: Scribble participates in Hippo signaling and is required for normal zebrafish pronephros development.
Lpp interacts with the PCP protein Scrib in zebrafish, and that Lpp and Scrib cooperate for the mediation of convergence and extension.
Title: Lpp is involved in Wnt/PCP signaling and acts together with Scrib to mediate convergence and extension movements during zebrafish gastrulation.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in activation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within anterior/posterior axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in apoptotic process involved in morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within commissural neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within convergent extension involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in establishment of apical/basal cell polarity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within establishment of mitotic spindle orientation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of planar polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of epithelial cell apical/basal polarity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within motor neuron migration	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of mitotic cell cycle	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within neural tube formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuromast development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neurotransmitter receptor transport postsynaptic membrane to endosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in neurotransmitter receptor transport, endosome to postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in receptor clustering	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within vasculature development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vasculature development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in adherens junction	IBA Inferred from Biological aspect of Ancestor more info
located_in adherens junction	ISS Inferred from Sequence or Structural Similarity more info
located_in anchoring junction	IEA Inferred from Electronic Annotation more info
is_active_in basolateral plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cell leading edge	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with postsynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with presynaptic membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein scribble homolog

Names: landlocked; llk; scribbled planar cell polarity protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007175.2 → NP_001007176.1 protein scribble homolog

See identical proteins and their annotated locations for NP_001007176.1

Status: VALIDATED

Source sequence(s)

AL772146, CT574559

UniProtKB/Swiss-Prot

Q4H4B6

Related

ENSDARP00000068701.2, ENSDART00000074212.4

Conserved Domains (6) summary

cd00116
Location:12 → 262

LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...

cd00992
Location:1003 → 1091

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

pfam06484
Location:1290 → 1404

Ten_N; Teneurin Intracellular Region

pfam12799
Location:289 → 329

LRR_4; Leucine Rich repeats (2 copies)

pfam13855
Location:36 → 94

LRR_8; Leucine rich repeat

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007118.7 Reference GRCz11 Primary Assembly

Range

41159188..41275232

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021477422.2 → XP_021333097.1 protein scribble homolog isoform X8

UniProtKB/TrEMBL

A0A8M9PNM8

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477414.2 → XP_021333089.1 protein scribble homolog isoform X1

UniProtKB/TrEMBL

A0A8M9Q7J8

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477426.2 → XP_021333101.1 protein scribble homolog isoform X13

UniProtKB/TrEMBL

A0A8M9QBQ1

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477419.2 → XP_021333094.1 protein scribble homolog isoform X6

UniProtKB/TrEMBL

A0A8M9Q7K5

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477424.2 → XP_021333099.1 protein scribble homolog isoform X10

UniProtKB/TrEMBL

A0A8M9Q7L2

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_068222177.1 → XP_068078278.1 protein scribble homolog isoform X17
XM_021477427.2 → XP_021333102.1 protein scribble homolog isoform X14

UniProtKB/TrEMBL

A0A8M9PNN3

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477425.2 → XP_021333100.1 protein scribble homolog isoform X11

UniProtKB/TrEMBL

A0A8M9QGP6

Conserved Domains (4) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

cl26464
Location:1294 → 1592

Atrophin-1; Atrophin-1 family
XM_068222176.1 → XP_068078277.1 protein scribble homolog isoform X16
XM_068222179.1 → XP_068078280.1 protein scribble homolog isoform X19
XM_021477423.2 → XP_021333098.1 protein scribble homolog isoform X9

UniProtKB/TrEMBL

A0A8M9Q190

Conserved Domains (4) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

cl26464
Location:1294 → 1613

Atrophin-1; Atrophin-1 family
XM_068222178.1 → XP_068078279.1 protein scribble homolog isoform X18
XM_021477428.2 → XP_021333103.1 protein scribble homolog isoform X15

UniProtKB/TrEMBL

A0A8M9Q197

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_068222180.1 → XP_068078281.1 protein scribble homolog isoform X21
XM_068222184.1 → XP_068078285.1 protein scribble homolog isoform X28
XM_068222181.1 → XP_068078282.1 protein scribble homolog isoform X24
XM_021477416.2 → XP_021333091.1 protein scribble homolog isoform X3

UniProtKB/TrEMBL

A0A8M9QBP1

Conserved Domains (4) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

cl26464
Location:1294 → 1572

Atrophin-1; Atrophin-1 family
XM_068222174.1 → XP_068078275.1 protein scribble homolog isoform X12
XM_021477421.2 → XP_021333096.1 protein scribble homolog isoform X7

UniProtKB/TrEMBL

A0A8M9QBP6

Conserved Domains (4) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

cl26464
Location:1294 → 1618

Atrophin-1; Atrophin-1 family
XM_021477429.2 → XP_021333104.1 protein scribble homolog isoform X20

UniProtKB/TrEMBL

A0A8M9Q7L7

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477430.2 → XP_021333105.1 protein scribble homolog isoform X22

UniProtKB/TrEMBL

A0A8M9QGP9

Conserved Domains (4) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

cl25496
Location:1298 → 1448

Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
XM_068222183.1 → XP_068078284.1 protein scribble homolog isoform X27

Related

ENSDARP00000143072.1, ENSDART00000174212.2
XM_068222185.1 → XP_068078286.1 protein scribble homolog isoform X29
XM_068222187.1 → XP_068078288.1 protein scribble homolog isoform X31
XM_021477432.2 → XP_021333107.1 protein scribble homolog isoform X25

UniProtKB/TrEMBL

A0A8M9PNN8

Conserved Domains (4) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

cl25751
Location:1299 → 1610

DUF4045; Domain of unknown function (DUF4045)
XM_021477417.2 → XP_021333092.1 protein scribble homolog isoform X4

UniProtKB/TrEMBL

A0A8M9PNM3

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477431.2 → XP_021333106.1 protein scribble homolog isoform X23

UniProtKB/TrEMBL

A0A8M9QBQ7

Conserved Domains (4) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1004 → 1092

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]

cl26464
Location:1236 → 1495

Atrophin-1; Atrophin-1 family
XM_068222182.1 → XP_068078283.1 protein scribble homolog isoform X26
XM_068222186.1 → XP_068078287.1 protein scribble homolog isoform X30
XM_068222189.1 → XP_068078290.1 protein scribble homolog isoform X33

Related

ENSDARP00000143155.1, ENSDART00000174204.2
XM_068222188.1 → XP_068078289.1 protein scribble homolog isoform X32
XM_021477418.2 → XP_021333093.1 protein scribble homolog isoform X5

UniProtKB/TrEMBL

A0A8M9Q183

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:983 → 1071

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477415.2 → XP_021333090.1 protein scribble homolog isoform X2

UniProtKB/TrEMBL

A0A8M9QGN8

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1003 → 1091

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]
XM_021477433.2 → XP_021333108.1 protein scribble homolog isoform X34

UniProtKB/TrEMBL

A0A8M9Q1A3

Conserved Domains (3) summary

COG4886
Location:37 → 306

LRR; Leucine-rich repeat (LRR) protein [Transcription]

cd00992
Location:1003 → 1091

PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...

sd00033
Location:14 → 37

LRR_RI; leucine-rich repeat [structural motif]