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    CDC42BPB CDC42 binding protein kinase beta [ Python bivittatus (Burmese python) ]

    Gene ID: 103054431, updated on 11-Mar-2024

    Summary

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    Gene symbol
    CDC42BPB
    Gene description
    CDC42 binding protein kinase beta
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Python bivittatus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera; Serpentes; Henophidia; Pythonidae; Python
    Orthologs
    human mouse all
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    Genomic context

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    See CDC42BPB in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    102 current Python_molurus_bivittatus-5.0.2 (GCF_000186305.1) Unplaced Scaffold NW_006534534.1 (25999..149474, complement)

    NW_006534534.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_006534534 Unplaced Scaffold Reference Python_molurus_bivittatus-5.0.2 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK beta
    Names
    CDC42 binding protein kinase beta (DMPK-like)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Python bivittatus Annotation Release 102 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Python_molurus_bivittatus-5.0.2 Primary Assembly

    Genomic

    1. NW_006534534.1 Reference Python_molurus_bivittatus-5.0.2 Primary Assembly

      Range
      25999..149474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_025170649.1 → XP_025026417.1  serine/threonine-protein kinase MRCK beta isoform X3

      UniProtKB/TrEMBL
      A0A9F5ITA4
      Conserved Domains (7) summary
      COG0419
      Location:423 → 935
      SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]
      cd00029
      Location:1004 → 1053
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00132
      Location:1561 → 1602
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cd01243
      Location:1063 → 1197
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      pfam00780
      Location:1223 → 1488
      CNH; CNH domain
      pfam15796
      Location:529 → 607
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl21453
      Location:3 → 412
      PKc_like; Protein Kinases, catalytic domain

    2. XM_007434411.3 → XP_007434473.1  serine/threonine-protein kinase MRCK beta isoform X2

      UniProtKB/TrEMBL
      A0A9F2WBS2
      Conserved Domains (8) summary
      pfam08826
      Location:880 → 936
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77 → 343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:502 → 785
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:1029 → 1078
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1088 → 1222
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      pfam00780
      Location:1248 → 1513
      CNH; CNH domain
      pfam15796
      Location:529 → 607
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl21453
      Location:3 → 412
      PKc_like; Protein Kinases, catalytic domain

    3. XM_015889125.2 → XP_015744611.1  serine/threonine-protein kinase MRCK beta isoform X1

      UniProtKB/TrEMBL
      A0A9F3QT59
      Conserved Domains (8) summary
      pfam08826
      Location:880 → 936
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:77 → 343
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:502 → 785
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:1034 → 1083
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1093 → 1227
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      pfam00780
      Location:1253 → 1518
      CNH; CNH domain
      pfam15796
      Location:529 → 607
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl21453
      Location:3 → 412
      PKc_like; Protein Kinases, catalytic domain
    Nucleotide Protein
    Heading Accession and Version

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