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    Pla2g2e phospholipase A2, group IIE [ Mus musculus (house mouse) ]

    Gene ID: 26970, updated on 28-Oct-2024

    Summary

    Official Symbol
    Pla2g2eprovided by MGI
    Official Full Name
    phospholipase A2, group IIEprovided by MGI
    Primary source
    MGI:MGI:1349660
    See related
    Ensembl:ENSMUSG00000028751 AllianceGenome:MGI:1349660
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Enables calcium-dependent phospholipase A2 activity. Involved in phosphatidylcholine metabolic process and phosphatidylglycerol metabolic process. Acts upstream of or within low-density lipoprotein particle remodeling. Located in extracellular region. Is expressed in several structures, including alimentary system; cranium; heart; respiratory system; and telencephalon. Orthologous to human PLA2G2E (phospholipase A2 group IIE). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 4.5), genital fat pad adult (RPKM 2.9) and 8 other tissues See more
    Orthologs
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    Genomic context

    See Pla2g2e in Genome Data Viewer
    Location:
    4 D3; 4 70.57 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (138605253..138610125)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (138877911..138882817)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer mm9_chr4:138422386-138422686 Neighboring gene predicted gene, 32930 Neighboring gene predicted gene 13030 Neighboring gene OTU domain containing 3 Neighboring gene predicted gene, 18097

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables calcium-dependent phospholipase A2 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium-dependent phospholipase A2 activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium-dependent phospholipase A2 activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables calcium-dependent phospholipase A2 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phospholipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in arachidonate secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within low-density lipoprotein particle remodeling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phosphatidylcholine metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylcholine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in phosphatidylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylglycerol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    group IIE secretory phospholipase A2
    Names
    GIIE sPLA2
    mGIIEsPLA2s
    phosphatidylcholine 2-acylhydrolase 2E
    sPLA2-IIE
    NP_036174.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_012044.2NP_036174.1  group IIE secretory phospholipase A2 precursor

      See identical proteins and their annotated locations for NP_036174.1

      Status: PROVISIONAL

      Source sequence(s)
      AL844178
      Consensus CDS
      CCDS18835.1
      UniProtKB/Swiss-Prot
      Q9QUL3
      UniProtKB/TrEMBL
      Q3UG05
      Related
      ENSMUSP00000030531.8, ENSMUST00000030531.14
      Conserved Domains (1) summary
      pfam00068
      Location:23127
      Phospholip_A2_1; Phospholipase A2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      138605253..138610125
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)