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    cdnf cerebral dopamine neurotrophic factor [ Danio rerio (zebrafish) ]

    Gene ID: 100037317, updated on 2-Nov-2024

    Summary

    Official Symbol
    cdnfprovided by ZNC
    Official Full Name
    cerebral dopamine neurotrophic factorprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070410-37
    See related
    Ensembl:ENSDARG00000075501 AllianceGenome:ZFIN:ZDB-GENE-070410-37
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:162209
    Summary
    Predicted to enable growth factor activity. Acts upstream of or within regulation of dopaminergic neuron differentiation. Predicted to be located in extracellular region. Predicted to be active in endoplasmic reticulum and extracellular space. Is expressed in several structures, including brain; female organism; heart; male organism; and otic vesicle. Orthologous to human CDNF (cerebral dopamine neurotrophic factor). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
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    Genomic context

    See cdnf in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 4 NC_007115.7 (9587968..9592402, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 4 NC_007115.6 (9587052..9591486, complement)

    Chromosome 4 - NC_007115.7Genomic Context describing neighboring genes Neighboring gene thymidine phosphorylase Neighboring gene SH3 and multiple ankyrin repeat domains 3b Neighboring gene heat shock protein 14 Neighboring gene uncharacterized LOC137490074 Neighboring gene DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae)

    Genomic regions, transcripts, and products

    Expression

    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    General gene information

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables growth factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in dopaminergic neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neuron projection development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of dopaminergic neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cerebral dopamine neurotrophic factor
    Names
    arginine-rich, mutated in early stage tumors-like 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001123281.1NP_001116753.1  cerebral dopamine neurotrophic factor precursor

      See identical proteins and their annotated locations for NP_001116753.1

      Status: PROVISIONAL

      Source sequence(s)
      BX901962
      UniProtKB/TrEMBL
      A0A8N1Z028, A4QNW4
      Related
      ENSDARP00000100729.3, ENSDART00000114060.4
      Conserved Domains (1) summary
      pfam10208
      Location:27172
      Armet; Degradation arginine-rich protein for mis-folding

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007115.7 Reference GRCz11 Primary Assembly

      Range
      9587968..9592402 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394550.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      139422..143853 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395230.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      11930..16364 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)