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    Ipo9 importin 9 [ Mus musculus (house mouse) ]

    Gene ID: 226432, updated on 28-Oct-2024

    Summary

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    Official Symbol
    Ipo9provided by MGI
    Official Full Name
    importin 9provided by MGI
    Primary source
    MGI:MGI:1918944
    See related
    Ensembl:ENSMUSG00000041879 AllianceGenome:MGI:1918944
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Imp9; Ranbp9; 0710008K06Rik
    Summary
    Enables histone binding activity. Acts upstream of or within protein import into nucleus. Predicted to be located in cytoplasm. Predicted to be active in cytosol and nuclear envelope. Is expressed in several structures, including central nervous system and retina. Orthologous to human IPO9 (importin 9). [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 30.3), limb E14.5 (RPKM 26.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ipo9 in Genome Data Viewer
    Location:
    1 E4; 1 58.6 cM
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (135310050..135358260, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (135382312..135430499, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_02362 Neighboring gene leiomodin 1 (smooth muscle) Neighboring gene STARR-seq mESC enhancer starr_02364 Neighboring gene shisa family member 4 Neighboring gene STARR-seq mESC enhancer starr_02365 Neighboring gene STARR-positive B cell enhancer ABC_E10038 Neighboring gene neuron navigator 1 Neighboring gene microRNA 1231 Neighboring gene STARR-seq mESC enhancer starr_02370 Neighboring gene STARR-seq mESC enhancer starr_02371 Neighboring gene predicted gene, 32940

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Expression and subcellular distribution of imp13 are regulated in brain development. You P, et al. In Vitro Cell Dev Biol Anim, 2013 May. PMID 23605716, Free PMC Article
    2. The roles of multiple importins for nuclear import of murine aristaless-related homeobox protein. Lin W, et al. J Biol Chem, 2009 Jul 24. PMID 19494118, Free PMC Article
    3. Multiple pathways contribute to nuclear import of core histones. Mühlhäusser P, et al. EMBO Rep, 2001 Aug. PMID 11493596, Free PMC Article
    4. Strain-specific modifier genes governing craniofacial phenotypes. Mukhopadhyay P, et al. Birth Defects Res A Clin Mol Teratol, 2012 Mar. PMID 22371338, Free PMC Article
    5. Active maintenance of nuclear actin by importin 9 supports transcription. Dopie J, et al. Proc Natl Acad Sci U S A, 2012 Feb 28. PMID 22323606, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Transgenic (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • mKIAA1192

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables histone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone chaperone activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables histone chaperone activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables nuclear import signal receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables nuclear import signal receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables small GTPase binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteasome localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein import into nucleus ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein stabilization ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    acts_upstream_of_or_within ribosome biogenesis ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nuclear envelope IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    importin-9
    Names
    Ran binding protein 9
    ran-binding protein 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357575.1 → NP_001344504.1  importin-9 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC016814
      UniProtKB/Swiss-Prot
      Q91YE6, Q924M3, Q924M4
      Conserved Domains (1) summary
      cl27876
      Location:3 → 776
      Cse1; Cse1

    2. NM_001357576.1 → NP_001344505.1  importin-9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC016814
      UniProtKB/Swiss-Prot
      Q91YE6, Q924M3, Q924M4
      Conserved Domains (1) summary
      COG5656
      Location:192 → 749
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

    3. NM_001357577.1 → NP_001344506.1  importin-9 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC016814
      UniProtKB/Swiss-Prot
      Q91YE6, Q924M3, Q924M4
      Conserved Domains (1) summary
      COG5656
      Location:192 → 749
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

    4. NM_001357578.1 → NP_001344507.1  importin-9 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC016814
      Conserved Domains (1) summary
      cl27876
      Location:61 → 618
      Cse1

    5. NM_153774.1 → NP_722469.1  importin-9 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC016814, BC056469, CD347972
      Consensus CDS
      CCDS35719.1
      UniProtKB/Swiss-Prot
      Q91YE6, Q924M3, Q924M4
      UniProtKB/TrEMBL
      E9QKZ2
      Related
      ENSMUSP00000036093.8, ENSMUST00000041023.14
      Conserved Domains (3) summary
      smart00913
      Location:43 → 117
      IBN_N; Importin-beta N-terminal domain
      COG5656
      Location:22 → 900
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
      sd00044
      Location:420 → 459
      HEAT; HEAT repeat [structural motif]

    RNA

    1. NR_151727.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC016814, AK161881, BB851521, BC056469, BM947606, CB245332, CD741683

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      135310050..135358260 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163945.1 → XP_036019838.1  importin-9 isoform X1

      UniProtKB/Swiss-Prot
      Q91YE6, Q924M3, Q924M4
      Conserved Domains (1) summary
      COG5657
      Location:34 → 812
      CSE1; CAS/CSE protein involved in chromosome segregation [Cell division and chromosome partitioning]

    2. XM_006529437.2 → XP_006529500.1  importin-9 isoform X2

      See identical proteins and their annotated locations for XP_006529500.1

      UniProtKB/Swiss-Prot
      Q91YE6, Q924M3, Q924M4
      Conserved Domains (1) summary
      COG5656
      Location:192 → 749
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]

    3. XM_036163950.1 → XP_036019843.1  importin-9 isoform X3

      Conserved Domains (1) summary
      COG5656
      Location:192 → 749
      SXM1; Importin, protein involved in nuclear import [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91YE6.3 GenPept UniProtKB/Swiss-Prot:Q91YE6

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