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    Vezf1 vascular endothelial zinc finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 22344, updated on 2-Nov-2024

    Summary

    Official Symbol
    Vezf1provided by MGI
    Official Full Name
    vascular endothelial zinc finger 1provided by MGI
    Primary source
    MGI:MGI:1313291
    See related
    Ensembl:ENSMUSG00000018377 AllianceGenome:MGI:1313291
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    db1
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within angiogenesis and endothelial cell development. Located in nucleus. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and liver. Human ortholog(s) of this gene implicated in dilated cardiomyopathy. Orthologous to human VEZF1 (vascular endothelial zinc finger 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 16.4), CNS E14 (RPKM 15.8) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Vezf1 in Genome Data Viewer
    Location:
    11 C; 11 52.4 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (87959084..87975555)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (88068199..88084729)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38610 Neighboring gene STARR-positive B cell enhancer ABC_E9835 Neighboring gene STARR-seq mESC enhancer starr_30308 Neighboring gene serine and arginine-rich splicing factor 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:87905511-87905664 Neighboring gene RIKEN cDNA 2210416O15 gene Neighboring gene CUE domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_30316 Neighboring gene STARR-positive B cell enhancer ABC_E8441 Neighboring gene mitochondrial ribosomal protein S23

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in nucleoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    vascular endothelial zinc finger 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402868.1NP_001389797.1  vascular endothelial zinc finger 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL593853
    2. NM_001402869.1NP_001389798.1  vascular endothelial zinc finger 1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL593853
    3. NM_001402870.1NP_001389799.1  vascular endothelial zinc finger 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL593853
    4. NM_001402871.1NP_001389800.1  vascular endothelial zinc finger 1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL593853
    5. NM_001402872.1NP_001389801.1  vascular endothelial zinc finger 1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL593853
      Related
      ENSMUSP00000114394.2, ENSMUST00000143052.2
    6. NM_001402873.1NP_001389802.1  vascular endothelial zinc finger 1 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL593853
    7. NM_001402874.1NP_001389803.1  vascular endothelial zinc finger 1 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL593853
    8. NM_016686.5NP_057895.2  vascular endothelial zinc finger 1 isoform 1

      See identical proteins and their annotated locations for NP_057895.2

      Status: VALIDATED

      Source sequence(s)
      AL593853
      Consensus CDS
      CCDS48880.1
      UniProtKB/TrEMBL
      Q5SXC4
      Related
      ENSMUSP00000018521.5, ENSMUST00000018521.11
      Conserved Domains (2) summary
      sd00017
      Location:176196
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:188213
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      87959084..87975555
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036156628.1XP_036012521.1  vascular endothelial zinc finger 1 isoform X4

      Conserved Domains (2) summary
      COG5189
      Location:230287
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:208228
      ZF_C2H2; C2H2 Zn finger [structural motif]
    2. XM_036156626.1XP_036012519.1  vascular endothelial zinc finger 1 isoform X1

      Conserved Domains (4) summary
      PRK12799
      Location:415532
      motB; flagellar motor protein MotB; Reviewed
      COG5189
      Location:230287
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:208228
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:206228
      zf-C2H2; Zinc finger, C2H2 type
    3. XM_036156629.1XP_036012522.1  vascular endothelial zinc finger 1 isoform X5

      Conserved Domains (2) summary
      COG5189
      Location:230287
      SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
      sd00017
      Location:208228
      ZF_C2H2; C2H2 Zn finger [structural motif]
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