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    FIP1L1 factor interacting with PAPOLA and CPSF1 [ Homo sapiens (human) ]

    Gene ID: 81608, updated on 3-Nov-2024

    Summary

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    Official Symbol
    FIP1L1provided by HGNC
    Official Full Name
    factor interacting with PAPOLA and CPSF1provided by HGNC
    Primary source
    HGNC:HGNC:19124
    See related
    Ensembl:ENSG00000145216 MIM:607686; AllianceGenome:HGNC:19124
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Rhe; FIP1; hFip1
    Summary
    This gene encodes a subunit of the CPSF (cleavage and polyadenylation specificity factor) complex that polyadenylates the 3' end of mRNA precursors. This gene, the homolog of yeast Fip1 (factor interacting with PAP), binds to U-rich sequences of pre-mRNA and stimulates poly(A) polymerase activity. Its N-terminus contains a PAP-binding site and its C-terminus an RNA-binding domain. An interstitial chromosomal deletion on 4q12 creates an in-frame fusion of human genes FIP1L1 and PDGFRA (platelet-derived growth factor receptor, alpha). The FIP1L1-PDGFRA fusion gene encodes a constitutively activated tyrosine kinase that joins the first 233 amino acids of FIP1L1 to the last 523 amino acids of PDGFRA. This gene fusion and chromosomal deletion is the cause of some forms of idiopathic hypereosinophilic syndrome (HES). This syndrome, recently reclassified as chronic eosinophilic leukemia (CEL), is responsive to treatment with tyrosine kinase inhibitors. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in testis (RPKM 13.3), brain (RPKM 11.1) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See FIP1L1 in Genome Data Viewer
    Location:
    4q12
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (53377641..53460862)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (56864883..56948080)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (54243808..54327029)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene sec1 family domain containing 2 Neighboring gene uncharacterized LOC124900701 Neighboring gene VISTA enhancer hs1668 Neighboring gene VISTA enhancer hs1460 Neighboring gene NANOG hESC enhancer GRCh37_chr4:54102933-54103444 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr4:54103445-54103956 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54122352-54122863 Neighboring gene ReSE screen-validated silencer GRCh37_chr4:54140029-54140243 Neighboring gene RNA, U6 small nuclear 310, pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:54195258-54195835 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21560 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21562 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21561 Neighboring gene uncharacterized LOC105377654 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54243526-54244074 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:54244075-54244623 Neighboring gene LNX1 antisense RNA 1 Neighboring gene ligand of numb-protein X 1 Neighboring gene COMMD5 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance. Gorantla SP, et al. Leukemia, 2015 Aug. PMID 25761934
    2. FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia. Iwasaki J, et al. Ann Hematol, 2014 Sep. PMID 24763514
    3. Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis. Muckenfuss LM, et al. Elife, 2022 Sep 8. PMID 36073787, Free PMC Article
    4. Myeloid neoplasm with eosinophilia associated with isolated extramedullary FIP1L1/PDGFRA rearrangement. Hilal T, et al. Cancer Genet, 2018 Jan. PMID 29310833
    5. Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis. Skarp S, et al. PLoS One, 2018. PMID 30157244, Free PMC Article

    See all (171) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
      Title: Fip1 is a multivalent interaction scaffold for processing factors in human mRNA 3' end biogenesis.
    2. FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction.
      Title: FIP1L1-PDGFRA-Associated Hypereosinophilic Syndrome as a Treatable Cause of Watershed Infarction.
    3. Exquisite response to imatinib mesylate in FIP1L1-PDGFRA-mutated hypereosinophilic syndrome: a 12-year experience of the Polish Hypereosinophilic Syndrome Study Group.
      Title: Exquisite response to imatinib mesylate in FIP1L1-PDGFRA-mutated hypereosinophilic syndrome: a 12-year experience of the Polish Hypereosinophilic Syndrome Study Group.
    4. Two identified variants revealed novel candidate genes for hip and knee osteoarthritis. OLIG3 and FIP1L1 have specific roles in transcription and may effect expression of other genes. Identified variants in these genes may thus have a role in the regulatory events leading to osteoarthritis.
      Title: Whole exome sequencing in Finnish families identifies new candidate genes for osteoarthritis.
    5. Herein, we report a case of a 53-year-old man with eosinophilia and a well-differentiated extramedullary myeloid tumor with evidence of FIP1L1/PDGFRA rearrangement by fluorescent in situ hybridization in the extramedullary tissue.
      Title: Myeloid neoplasm with eosinophilia associated with isolated extramedullary FIP1L1/PDGFRA rearrangement.
    6. The authors define the molecular architecture of the core human CPSF complex comprising CPSF160, WDR33, CPSF30 and Fip1 and identify specific domains involved in inter-subunit interactions. Together, these results shed light on the function of CPSF in mediating polyA signal-dependent RNA cleavage and polyadenylation.
      Title: Structural insights into the assembly and polyA signal recognition mechanism of the human CPSF complex.
    7. Case Report: concurrent development of myeloproliferative hypereosinophilic syndrome and lymphomatoid papulosis associated with FIP1L1-PDGFRA gene fusion.
      Title: Imatinib Treatment of Lymphomatoid Papulosis Associated with Myeloproliferative Hypereosinophilic Syndrome Presenting the FIP1L1-PDGFRA Fusion Gene.
    8. FIP1L1/ PDGFRA associated chronic eosinophilic leukemia has an excellent long-term prognosis following imatinib therapy.
      Title: Long-term outcomes of imatinib in patients with FIP1L1/ PDGFRA associated chronic eosinophilic leukemia: experience of a single center in China.
    9. F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC and is associated with kinase inhibitor resistance in hypereosinophilic syndrome and chronic eosinophilic leukemia.
      Title: F604S exchange in FIP1L1-PDGFRA enhances FIP1L1-PDGFRA protein stability via SHP-2 and SRC: a novel mode of kinase inhibitor resistance.
    10. FIP1L1 differentially contributes to the pathogenesis of distinct types of leukemia.
      Title: FIP1L1 presence in FIP1L1-RARA or FIP1L1-PDGFRA differentially contributes to the pathogenesis of distinct types of leukemia.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.
    EBI GWAS Catalog
    Identification of a variant in KDR associated with serum VEGFR2 and pharmacodynamics of pazopanib.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify FIP1 like 1 protein (FIP1L1), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33619, DKFZp586K0717

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of mRNA cleavage and polyadenylation specificity factor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    pre-mRNA 3'-end-processing factor FIP1
    Names
    FIP1 like 1
    FIP1-like 1 protein
    FIP1L1 cleavage and polyadenylation specific factor subunit
    factor interacting with PAP
    rearranged in hypereosinophilia

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008644.1 RefSeqGene

      Range
      4989..88210
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134937.2 → NP_001128409.1  pre-mRNA 3'-end-processing factor FIP1 isoform 2

      See identical proteins and their annotated locations for NP_001128409.1

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS47055.1
      UniProtKB/TrEMBL
      A0A994J6C9
      Related
      ENSP00000351383.5, ENST00000358575.9
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    2. NM_001134938.2 → NP_001128410.1  pre-mRNA 3'-end-processing factor FIP1 isoform 3

      See identical proteins and their annotated locations for NP_001128410.1

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS47056.1
      UniProtKB/TrEMBL
      A0A994J6P8
      Related
      ENSP00000302993.6, ENST00000306932.10
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    3. NM_001376744.1 → NP_001363673.1  pre-mRNA 3'-end-processing factor FIP1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6C9
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    4. NM_001376745.1 → NP_001363674.1  pre-mRNA 3'-end-processing factor FIP1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93495.1
      UniProtKB/TrEMBL
      A0A994J6B4, A0A994J6C9
      Related
      ENSP00000515305.1, ENST00000703454.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    5. NM_001376746.1 → NP_001363675.1  pre-mRNA 3'-end-processing factor FIP1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93499.1
      UniProtKB/TrEMBL
      A0A994J3L5, A0A994J6C9
      Related
      ENSP00000515334.1, ENST00000703484.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    6. NM_001376747.1 → NP_001363676.1  pre-mRNA 3'-end-processing factor FIP1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93504.1
      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J6D6
      Related
      ENSP00000515335.1, ENST00000703485.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    7. NM_001376748.1 → NP_001363677.1  pre-mRNA 3'-end-processing factor FIP1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93503.1
      UniProtKB/TrEMBL
      A0A994J469, A0A994J6P8
      Related
      ENSP00000515336.1, ENST00000703486.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    8. NM_001376749.1 → NP_001363678.1  pre-mRNA 3'-end-processing factor FIP1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93501.1
      UniProtKB/TrEMBL
      A0A994J3I9, A0A994J6C9
      Related
      ENSP00000515304.1, ENST00000703453.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    9. NM_001376750.1 → NP_001363679.1  pre-mRNA 3'-end-processing factor FIP1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93515.1
      UniProtKB/TrEMBL
      A0A994J458, A0A994J6C9
      Related
      ENSP00000515326.1, ENST00000703475.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    10. NM_001376751.1 → NP_001363680.1  pre-mRNA 3'-end-processing factor FIP1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93510.1
      UniProtKB/TrEMBL
      A0A994J6C9, A0A994J6R0
      Related
      ENSP00000515333.1, ENST00000703483.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    11. NM_001376752.1 → NP_001363681.1  pre-mRNA 3'-end-processing factor FIP1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93502.1
      UniProtKB/TrEMBL
      A0A994J464, A0A994J6C9
      Related
      ENSP00000515331.1, ENST00000703481.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    12. NM_001376753.1 → NP_001363682.1  pre-mRNA 3'-end-processing factor FIP1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    13. NM_001376754.1 → NP_001363683.1  pre-mRNA 3'-end-processing factor FIP1 isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93506.1
      UniProtKB/TrEMBL
      A0A994J474, A0A994J6C9
      Related
      ENSP00000515342.1, ENST00000703492.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    14. NM_001376755.1 → NP_001363684.1  pre-mRNA 3'-end-processing factor FIP1 isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93512.1
      UniProtKB/TrEMBL
      A0A994J3T5, A0A994J6C9
      Related
      ENSP00000515343.1, ENST00000703497.1
      Conserved Domains (1) summary
      pfam05182
      Location:153 → 195
      Fip1; Fip1 motif

    15. NM_001376756.1 → NP_001363685.1  pre-mRNA 3'-end-processing factor FIP1 isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6C9
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    16. NM_001376757.1 → NP_001363686.1  pre-mRNA 3'-end-processing factor FIP1 isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    17. NM_001376758.1 → NP_001363687.1  pre-mRNA 3'-end-processing factor FIP1 isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93519.1
      UniProtKB/TrEMBL
      A0A994J453, A0A994J6P8
      Related
      ENSP00000515321.1, ENST00000703470.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    18. NM_001376759.1 → NP_001363688.1  pre-mRNA 3'-end-processing factor FIP1 isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93497.1
      UniProtKB/TrEMBL
      A0A994J3S0, A0A994J6P8
      Related
      ENSP00000515327.1, ENST00000703476.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    19. NM_001376760.1 → NP_001363689.1  pre-mRNA 3'-end-processing factor FIP1 isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93518.1
      UniProtKB/TrEMBL
      A0A994J6C9, A0A994J6N5
      Related
      ENSP00000515303.1, ENST00000703452.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    20. NM_001376761.1 → NP_001363690.1  pre-mRNA 3'-end-processing factor FIP1 isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93500.1
      UniProtKB/TrEMBL
      A0A994J3S6, A0A994J6P8
      Related
      ENSP00000515332.1, ENST00000703482.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    21. NM_001376762.1 → NP_001363691.1  pre-mRNA 3'-end-processing factor FIP1 isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6C9
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    22. NM_001376764.1 → NP_001363693.1  pre-mRNA 3'-end-processing factor FIP1 isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93524.1
      UniProtKB/TrEMBL
      A0A994J442, A0A994J6C9
      Related
      ENSP00000515311.1, ENST00000703460.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    23. NM_001376765.1 → NP_001363694.1  pre-mRNA 3'-end-processing factor FIP1 isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93498.1
      UniProtKB/TrEMBL
      A0A994J3M0, A0A994J6P8
      Related
      ENSP00000515340.1, ENST00000703490.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    24. NM_001376766.1 → NP_001363695.1  pre-mRNA 3'-end-processing factor FIP1 isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93496.1
      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J3Q0
      Related
      ENSP00000515307.1, ENST00000703456.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    25. NM_001376767.1 → NP_001363696.1  pre-mRNA 3'-end-processing factor FIP1 isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93520.1
      UniProtKB/TrEMBL
      A0A994J6C9, A0A994J6P0
      Related
      ENSP00000515308.1, ENST00000703457.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    26. NM_001376768.1 → NP_001363697.1  pre-mRNA 3'-end-processing factor FIP1 isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93525.1
      UniProtKB/TrEMBL
      A0A994J3K5, A0A994J6C9
      Related
      ENSP00000515324.1, ENST00000703473.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    27. NM_001376769.1 → NP_001363698.1  pre-mRNA 3'-end-processing factor FIP1 isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93516.1
      UniProtKB/TrEMBL
      A0A994J3R0, A0A994J6P8
      Related
      ENSP00000515317.1, ENST00000703466.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    28. NM_001376770.1 → NP_001363699.1  pre-mRNA 3'-end-processing factor FIP1 isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    29. NM_001376771.1 → NP_001363700.1  pre-mRNA 3'-end-processing factor FIP1 isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93507.1
      UniProtKB/TrEMBL
      A0A994J438, A0A994J6P8
      Related
      ENSP00000515306.1, ENST00000703455.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    30. NM_001376772.1 → NP_001363701.1  pre-mRNA 3'-end-processing factor FIP1 isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93511.1
      UniProtKB/TrEMBL
      A0A994J6C9, A0A994J6E2
      Related
      ENSP00000515346.1, ENST00000703500.1
      Conserved Domains (1) summary
      pfam05182
      Location:133 → 160
      Fip1; Fip1 motif

    31. NM_001376773.1 → NP_001363702.1  pre-mRNA 3'-end-processing factor FIP1 isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93517.1
      UniProtKB/TrEMBL
      A0A994J3P6, A0A994J6P8
      Related
      ENSP00000515302.1, ENST00000703451.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    32. NM_001376774.1 → NP_001363703.1  pre-mRNA 3'-end-processing factor FIP1 isoform 33

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    33. NM_001376775.1 → NP_001363704.1  pre-mRNA 3'-end-processing factor FIP1 isoform 34

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93509.1
      UniProtKB/TrEMBL
      A0A994J6E0, A0A994J6P8
      Related
      ENSP00000515341.1, ENST00000703491.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    34. NM_001376776.1 → NP_001363705.1  pre-mRNA 3'-end-processing factor FIP1 isoform 35

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    35. NM_001376777.1 → NP_001363706.1  pre-mRNA 3'-end-processing factor FIP1 isoform 36

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    36. NM_001376778.1 → NP_001363707.1  pre-mRNA 3'-end-processing factor FIP1 isoform 37

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93522.1
      UniProtKB/TrEMBL
      A0A994J6P8, H0Y8P7
      Related
      ENSP00000421691.2, ENST00000504094.2
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    37. NM_001376779.1 → NP_001363708.1  pre-mRNA 3'-end-processing factor FIP1 isoform 38

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93521.1
      UniProtKB/TrEMBL
      A0A994J3J1, A0A994J6P8
      Related
      ENSP00000515309.1, ENST00000703458.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    38. NM_001376780.1 → NP_001363709.1  pre-mRNA 3'-end-processing factor FIP1 isoform 39

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93526.1
      UniProtKB/TrEMBL
      A0A994J3R5, A0A994J6P8
      Related
      ENSP00000515322.1, ENST00000703471.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    39. NM_001376781.1 → NP_001363710.1  pre-mRNA 3'-end-processing factor FIP1 isoform 40

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93523.1
      UniProtKB/TrEMBL
      A0A994J3K1, A0A994J6P8
      Related
      ENSP00000515319.1, ENST00000703468.1
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    40. NM_001376782.1 → NP_001363711.1  pre-mRNA 3'-end-processing factor FIP1 isoform 41

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:115 → 157
      Fip1; Fip1 motif

    41. NM_001376783.1 → NP_001363712.1  pre-mRNA 3'-end-processing factor FIP1 isoform 42

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6P8
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    42. NM_001376784.1 → NP_001363713.1  pre-mRNA 3'-end-processing factor FIP1 isoform 43

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:139 → 181
      Fip1; Fip1 motif

    43. NM_001376785.1 → NP_001363714.1  pre-mRNA 3'-end-processing factor FIP1 isoform 44

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      UniProtKB/TrEMBL
      A0A994J6C9

    44. NM_001376786.1 → NP_001363715.1  pre-mRNA 3'-end-processing factor FIP1 isoform 45

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93508.1
      UniProtKB/TrEMBL
      A0A994J3L0, A0A994J6Q5
      Related
      ENSP00000515328.1, ENST00000703478.1
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    45. NM_001410723.1 → NP_001397652.1  pre-mRNA 3'-end-processing factor FIP1 isoform 46

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93513.1
      UniProtKB/TrEMBL
      A0A994J6C6
      Related
      ENSP00000515320.1, ENST00000703469.1

    46. NM_001410724.1 → NP_001397653.1  pre-mRNA 3'-end-processing factor FIP1 isoform 47

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821
      Consensus CDS
      CCDS93514.1
      UniProtKB/TrEMBL
      A0A994J3Q5
      Related
      ENSP00000515312.1, ENST00000703461.1

    47. NM_030917.4 → NP_112179.2  pre-mRNA 3'-end-processing factor FIP1 isoform 1

      See identical proteins and their annotated locations for NP_112179.2

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821, AY366510, DN990103
      Consensus CDS
      CCDS3491.1
      UniProtKB/Swiss-Prot
      B4DIR3, G3XAD6, Q0VGE0, Q499Y4, Q49AU3, Q6UN15, Q7Z608, Q8WVN3, Q96F80, Q9H077
      UniProtKB/TrEMBL
      A0A994J6C9
      Related
      ENSP00000336752.6, ENST00000337488.11
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    RNA

    1. NR_164847.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821

    2. NR_164848.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821

    3. NR_164849.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC058822, AC098821

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      53377641..53460862
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416208.1 → XP_047272164.1  pre-mRNA 3'-end-processing factor FIP1 isoform X1

    2. XM_005265779.5 → XP_005265836.1  pre-mRNA 3'-end-processing factor FIP1 isoform X7

      UniProtKB/TrEMBL
      A0A994J3L0
      Conserved Domains (1) summary
      pfam05182
      Location:154 → 196
      Fip1; Fip1 motif

    3. XM_047416211.1 → XP_047272167.1  pre-mRNA 3'-end-processing factor FIP1 isoform X3

    4. XM_047416212.1 → XP_047272168.1  pre-mRNA 3'-end-processing factor FIP1 isoform X4

    5. XM_047416218.1 → XP_047272174.1  pre-mRNA 3'-end-processing factor FIP1 isoform X10

      UniProtKB/TrEMBL
      A0A994J6D3
      Related
      ENSP00000515330.1, ENST00000703480.1

    6. XM_047416215.1 → XP_047272171.1  pre-mRNA 3'-end-processing factor FIP1 isoform X8

    7. XM_047416210.1 → XP_047272166.1  pre-mRNA 3'-end-processing factor FIP1 isoform X2

    8. XM_047416214.1 → XP_047272170.1  pre-mRNA 3'-end-processing factor FIP1 isoform X6

    9. XM_047416216.1 → XP_047272172.1  pre-mRNA 3'-end-processing factor FIP1 isoform X9

    10. XM_047416213.1 → XP_047272169.1  pre-mRNA 3'-end-processing factor FIP1 isoform X5

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      56864883..56948080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350921.1 → XP_054206896.1  pre-mRNA 3'-end-processing factor FIP1 isoform X1

    2. XM_054350927.1 → XP_054206902.1  pre-mRNA 3'-end-processing factor FIP1 isoform X7

    3. XM_054350923.1 → XP_054206898.1  pre-mRNA 3'-end-processing factor FIP1 isoform X3

    4. XM_054350924.1 → XP_054206899.1  pre-mRNA 3'-end-processing factor FIP1 isoform X4

    5. XM_054350930.1 → XP_054206905.1  pre-mRNA 3'-end-processing factor FIP1 isoform X10

      UniProtKB/TrEMBL
      A0A994J6D3

    6. XM_054350928.1 → XP_054206903.1  pre-mRNA 3'-end-processing factor FIP1 isoform X8

    7. XM_054350922.1 → XP_054206897.1  pre-mRNA 3'-end-processing factor FIP1 isoform X2

    8. XM_054350926.1 → XP_054206901.1  pre-mRNA 3'-end-processing factor FIP1 isoform X6

    9. XM_054350929.1 → XP_054206904.1  pre-mRNA 3'-end-processing factor FIP1 isoform X9

    10. XM_054350925.1 → XP_054206900.1  pre-mRNA 3'-end-processing factor FIP1 isoform X5

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6UN15.1 GenPept UniProtKB/Swiss-Prot:Q6UN15

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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