SLC22A7 solute carrier family 22 member 7 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC22A7provided by HGNC
Official Full Name: solute carrier family 22 member 7provided by HGNC
Primary source: HGNC:HGNC:10971
See related: Ensembl:ENSG00000137204 MIM:604995; AllianceGenome:HGNC:10971
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NLT; OAT2; hOAT11
Summary: The protein encoded by this gene is involved in the sodium-independent transport and excretion of organic anions, some of which are potentially toxic. The encoded protein is an integral membrane protein and appears to be localized to the basolateral membrane of the kidney. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Expression: Biased expression in liver (RPKM 51.8) and kidney (RPKM 19.9) See more
Orthologs: mouse all
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Genomic context

Location:: 6p21.1

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (43295714..43305538)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (43127200..43134478)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (43265998..43273276)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.
Title: Plasma microRNA profiles: identification of miR-1229-3p as a novel chemoresistant and prognostic biomarker in gastric cancer.
Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7).
Title: Nicotinic acid transport into human liver involves organic anion transporter 2 (SLC22A7).
The role of OAT2-mediated hepatic uptake in determining the pharmacokinetics of several clinically important ECCS 1A drugs.
Title: Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.
The established OAT2 (SLC22A7)-substrate indomethacin showed a competitive interaction with cyclic nucleotide uptake.
Title: The role of OAT2 (SLC22A7) in the cyclic nucleotide biokinetics of human erythrocytes.
Large interindividual variability was noted in the hepatic expression of OAT2 (16-fold in human liver tissue and 23-fold in hepatocytes). OAT7, on the other hand, showed less interindividual variability (4-fold) in the livers, but high variability for the hepatocyte lots (27-fold). A significant positive correlation in OAT2 and OAT7 expression was observed, but expression levels were neither associated with age nor sex.
Title: Quantification of Hepatic Organic Anion Transport Proteins OAT2 and OAT7 in Human Liver Tissue and Primary Hepatocytes.
Lrh-1 transcriptionally regulates Oat2.
Title: Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics.
two human organic anion transporters OAT2 and OAT7 activities were assessed.
Title: In vitro studies with two human organic anion transporters: OAT2 and OAT7.
SLC22A7 variants were not significantly associated with hyperuricemia and gout in a New Zealand Maori and Pacific cohort.
Title: Population-Specific Resequencing Associates the ATP-Binding Cassette Subfamily C Member 4 Gene With Gout in New Zealand Māori and Pacific Men.
Two novel variants in SLC22A17 and SLC22A7 were significantly associated with anthracycline-induced cardiotoxicity.
Title: Genetic variants in SLC22A17 and SLC22A7 are associated with anthracycline-induced cardiotoxicity in children.
suggest that OAT2-mediated cGMP uptake does not occur via exchange with monocarboxylates, dicarboxylates, and hydroxyl ions
Title: Human organic anion transporter 2 is distinct from organic anion transporters 1 and 3 with respect to transport function.

Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Markers

D6S1790 (e-PCR)
- UniSTS:15404

SLC22A7_1483 (e-PCR)
- UniSTS:277734

SLC22A7_v499 (e-PCR)
- UniSTS:277734

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables alpha-ketoglutarate transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables organic anion transmembrane transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables organic anion transmembrane transporter activity	TAS Traceable Author Statement more info
enables prostaglandin transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium-independent organic anion transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sodium-independent organic anion transmembrane transporter activity	TAS Traceable Author Statement more info
enables transmembrane transporter activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in alpha-ketoglutarate transport	IDA Inferred from Direct Assay more info	PubMed
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in organic anion transport	TAS Traceable Author Statement more info	PubMed
involved_in prostaglandin transport	IDA Inferred from Direct Assay more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in xenobiotic metabolic process	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basal plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 22 member 7

Names: hOAT2; liver-specific transporter; novel liver transporter; organic anion transporter 11; organic anion transporter 2; solute carrier family 22 (organic anion transporter), member 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_006672.3 → NP_006663.2 solute carrier family 22 member 7 isoform a

See identical proteins and their annotated locations for NP_006663.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the shorter transcript and encodes the shorter isoform (a).

Source sequence(s)

AA705161, AF210455, BC033805, DA640137

Consensus CDS

CCDS4892.1

UniProtKB/Swiss-Prot

Q9Y694

Related

ENSP00000361670.3, ENST00000372589.7

Conserved Domains (2) summary

cd06174
Location:126 → 499

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 521

2A0119; cation transport protein
NM_153320.2 → NP_696961.2 solute carrier family 22 member 7 isoform b

See identical proteins and their annotated locations for NP_696961.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains an alternate segment in the 5' coding region compared to variant 1. The encoded isoform (b) is longer compared to isoform a.

Source sequence(s)

AA705161, BC033805, DA640137

Consensus CDS

CCDS4893.2

UniProtKB/Swiss-Prot

B2CZX6, Q5T046, Q5T048, Q5T050, Q9H2W5, Q9Y694

Related

ENSP00000361666.5, ENST00000372585.10

Conserved Domains (1) summary

TIGR00898
Location:11 → 523

2A0119; cation transport protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p14 Primary Assembly

Range

43295714..43305538

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047418104.1 → XP_047274060.1 solute carrier family 22 member 7 isoform X10
XM_017010199.3 → XP_016865688.1 solute carrier family 22 member 7 isoform X6
XM_011514256.4 → XP_011512558.1 solute carrier family 22 member 7 isoform X1

Conserved Domains (2) summary

cd06174
Location:206 → 563

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 585

2A0119; cation transport protein
XM_017010198.3 → XP_016865687.1 solute carrier family 22 member 7 isoform X3
XM_011514257.4 → XP_011512559.1 solute carrier family 22 member 7 isoform X2

Conserved Domains (2) summary

cd06174
Location:206 → 560

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 582

2A0119; cation transport protein
XM_047418103.1 → XP_047274059.1 solute carrier family 22 member 7 isoform X7
XM_024446313.2 → XP_024302081.1 solute carrier family 22 member 7 isoform X5

Conserved Domains (1) summary

cl26863
Location:11 → 520

Sugar_tr; Sugar (and other) transporter
XM_047418102.1 → XP_047274058.1 solute carrier family 22 member 7 isoform X4
XM_011514262.4 → XP_011512564.1 solute carrier family 22 member 7 isoform X8

Conserved Domains (2) summary

cd06174
Location:206 → 341

MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...

TIGR00898
Location:11 → 356

2A0119; cation transport protein
XM_047418105.1 → XP_047274061.1 solute carrier family 22 member 7 isoform X9