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    CTAGE4 CTAGE family member 4 [ Homo sapiens (human) ]

    Gene ID: 100128553, updated on 23-Nov-2023

    Summary

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    Official Symbol
    CTAGE4provided by HGNC
    Official Full Name
    CTAGE family member 4provided by HGNC
    Primary source
    HGNC:HGNC:24772
    See related
    Ensembl:ENSG00000288784 MIM:608910; AllianceGenome:HGNC:24772
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    cTAGE-4
    Summary
    Predicted to be involved in endoplasmic reticulum to Golgi vesicle-mediated transport; protein secretion; and vesicle cargo loading. Predicted to be integral component of membrane. Predicted to be active in endoplasmic reticulum exit site and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    7q35
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144183466..144186080)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145463943..145466557)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143880559..143883173)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily A member 3 pseudogene Neighboring gene olfactory receptor family 2 subfamily AO member 1 pseudogene Neighboring gene ARHGEF35 antisense RNA 1 Neighboring gene Rho guanine nucleotide exchange factor 35 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143901531-143902093 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143902094-143902655 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:143904530-143905158 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143905159-143905786 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:143906415-143907042 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:143935567-143936068 Neighboring gene olfactory receptor family 2 subfamily A member 42 Neighboring gene OR2A1 antisense RNA 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. cTAGE: a cutaneous T cell lymphoma associated antigen family with tumor-specific splicing. Usener D, et al. J Invest Dermatol, 2003 Jul. PMID 12839582
    2. Serological detection of cutaneous T-cell lymphoma-associated antigens. Eichmuller S, et al. Proc Natl Acad Sci U S A, 2001 Jan 16. PMID 11149944, Free PMC Article
    3. The DNA sequence of human chromosome 7. Hillier LW, et al. Nature, 2003 Jul 10. PMID 12853948
    4. Toward a complete human genome sequence. Sanger Center, et al. Genome Res, 1998 Nov. PMID 9847074
    5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. Lamesch P, et al. Genomics, 2007 Mar. PMID 17207965, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein secretion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    cTAGE family member 4
    Names
    cutaneous T-cell lymphoma-associated antigen 4
    cutaneous-T-cell-lymphoma-specific tumor antigen 4
    protein cTAGE-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198495.3 → NP_940897.2  cTAGE family member 4

      See identical proteins and their annotated locations for NP_940897.2

      Status: VALIDATED

      Source sequence(s)
      AC004889
      Consensus CDS
      CCDS55176.1
      UniProtKB/Swiss-Prot
      A8K871, O95046, Q8IX94
      UniProtKB/TrEMBL
      A0A5F9ZHA4
      Related
      ENSP00000419539.1, ENST00000486333.2
      Conserved Domains (3) summary
      pfam10211
      Location:157 → 229
      Ax_dynein_light; Axonemal dynein light chain
      pfam14662
      Location:107 → 298
      KASH_CCD; Coiled-coil region of CCDC155 or KASH
      pfam15233
      Location:338 → 445
      SYCE1; Synaptonemal complex central element protein 1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      144183466..144186080
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654715.1 Reference GRCh38.p14 PATCHES

      Range
      138031..140645
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      145463943..145466557
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IX94.3 GenPept UniProtKB/Swiss-Prot:Q8IX94

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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