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    SENP7 SUMO specific peptidase 7 [ Homo sapiens (human) ]

    Gene ID: 57337, updated on 3-Nov-2024

    Summary

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    Official Symbol
    SENP7provided by HGNC
    Official Full Name
    SUMO specific peptidase 7provided by HGNC
    Primary source
    HGNC:HGNC:30402
    See related
    Ensembl:ENSG00000138468 MIM:612846; AllianceGenome:HGNC:30402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
    Expression
    Ubiquitous expression in endometrium (RPKM 9.0), lymph node (RPKM 7.6) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SENP7 in Genome Data Viewer
    Location:
    3q12.3
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (101324205..101513212, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (104030073..104219481, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (101043049..101232056, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U13 Neighboring gene interphotoreceptor matrix proteoglycan 2 Neighboring gene zinc finger protein 90 pseudogene 1 Neighboring gene family with sequence similarity 136 member A pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101185392-101185939 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:101185940-101186486 Neighboring gene basic transcription factor 3 pseudogene 16 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:101203214-101204413 Neighboring gene small nucleolar RNA U13 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20164 Neighboring gene CRISPRi-validated cis-regulatory element chr3.3097 Neighboring gene ARB2 family member B, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:101274853-101275465 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20165 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20166 Neighboring gene tRNA methyltransferase 10C, mitochondrial RNase P subunit

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Novel SUMO-Protease SENP7S Regulates β-catenin Signaling and Mammary Epithelial Cell Transformation. Karami S, et al. Sci Rep, 2017 Apr 21. PMID 28429743, Free PMC Article
    2. Differential regulation of sentrinized proteins by a novel sentrin-specific protease. Gong L, et al. J Biol Chem, 2000 Feb 4. PMID 10652325
    3. Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. Lima CD, et al. J Biol Chem, 2008 Nov 14. PMID 18799455, Free PMC Article
    4. Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition. Bawa-Khalfe T, et al. Proc Natl Acad Sci U S A, 2012 Oct 23. PMID 23045645, Free PMC Article
    5. Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7. Ji P, et al. Biochem Biophys Res Commun, 2018 Jul 7. PMID 29777712

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells.
      Title: SENP7 senses oxidative stress to sustain metabolic fitness and antitumor functions of CD8+ T cells.
    2. DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
      Title: DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
    3. non-tumorigenic MCF10-2A cells with reduced SENP7S exhibit greater cell proliferation and anchorage-dependent growth. SENP7S depletion directly potentiates tumorigenic properties of MCF10-2A cells with induction of anchorage-independent growth and self-renewal in 3D-spheroid conditions. Collectively, the results identify SENP7S as a novel mediator of beta-catenin signaling and normal mammary epithelial cell physiology.
      Title: Novel SUMO-Protease SENP7S Regulates β-catenin Signaling and Mammary Epithelial Cell Transformation.
    4. SPOP inhibits hepatocellular carcinoma (HCC) cell metastasis via ubiquitin-dependent SENP7 proteolysis and may thus serve as a new opinion for the prevention of HCC metastasis.
      Title: Speckle-type POZ protein suppresses hepatocellular carcinoma cell migration and invasion via ubiquitin-dependent proteolysis of SUMO1/sentrin specific peptidase 7.
    5. c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4
      Title: c-Myc is targeted to the proteasome for degradation in a SUMOylation-dependent manner, regulated by PIAS1, SENP7 and RNF4.
    6. deSUMOylation by SENP7 is required to promote a permissive chromatin environment for DNA repair.
      Title: The deSUMOylase SENP7 promotes chromatin relaxation for homologous recombination DNA repair.
    7. differential splicing of the SENP7 regulates either tumor suppression or progression
      Title: Differential expression of SUMO-specific protease 7 variants regulates epithelial-mesenchymal transition.
    8. Loop 1 insertion in SENP6 and SENP7 as a platform to discriminate between SUMO1 and SUMO2/3 isoforms in this subclass of the SUMO protease family.
      Title: Swapping small ubiquitin-like modifier (SUMO) isoform specificity of SUMO proteases SENP6 and SENP7.
    9. SENP6 and SENP7 exhibit lower rates for processing pre-SUMO1, pre-SUMO2, or pre-SUMO3 in comparison with SENP2
      Title: Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7.
    Submit: New GeneRIF Correction

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1707, MGC157730

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables SUMO-specific endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables SUMO-specific endopeptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in antiviral innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein desumoylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein desumoylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in postsynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in presynaptic cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    sentrin-specific protease 7
    Names
    SUMO-1-specific protease 2
    SUMO1/sentrin specific peptidase 7
    sentrin/SUMO-specific protease SENP7
    NP_001070671.1
    NP_001269730.1
    NP_001269731.1
    NP_001269732.1
    NP_001269733.1
    NP_065705.3
    XP_005247719.1
    XP_011511340.1
    XP_011511342.1
    XP_011511343.1
    XP_011511344.1
    XP_011511347.1
    XP_016862415.1
    XP_016862417.1
    XP_047304583.1
    XP_047304584.1
    XP_054203333.1
    XP_054203334.1
    XP_054203335.1
    XP_054203336.1
    XP_054203337.1
    XP_054203338.1
    XP_054203339.1
    XP_054203340.1
    XP_054203341.1
    XP_054203342.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001077203.3 → NP_001070671.1  sentrin-specific protease 7 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as SENP7S) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AI858732, AL136599, BC129988
      Consensus CDS
      CCDS43121.1
      UniProtKB/TrEMBL
      J3QT09
      Related
      ENSP00000377654.2, ENST00000394094.6

    2. NM_001282801.2 → NP_001269730.1  sentrin-specific protease 7 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AI858732, AL136599, BC129988
      Consensus CDS
      CCDS63706.1
      UniProtKB/Swiss-Prot
      Q9BQF6
      Related
      ENSP00000313624.7, ENST00000314261.11
      Conserved Domains (1) summary
      cl23802
      Location:708 → 945
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    3. NM_001282802.2 → NP_001269731.1  sentrin-specific protease 7 isoform 4

      See identical proteins and their annotated locations for NP_001269731.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in its 5' UTR, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (4) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AI858732, AL136599, BC129988
      Consensus CDS
      CCDS63705.1
      UniProtKB/Swiss-Prot
      Q9BQF6
      Related
      ENSP00000342159.3, ENST00000348610.3
      Conserved Domains (1) summary
      COG5160
      Location:723 → 978
      ULP1; Protease, Ulp1 family [Posttranslational modification, protein turnover, chaperones]

    4. NM_001282803.2 → NP_001269732.1  sentrin-specific protease 7 isoform 5

      See identical proteins and their annotated locations for NP_001269732.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in its 5' UTR, initiates translation at a downstream start codon, and lacks two in-frame exons in the central coding region, compared to variant 1. The encoded isoform (5) is shorter, compared to isoform 1.
      Source sequence(s)
      AI858732, AL136599, BC129988
      Consensus CDS
      CCDS63704.1
      UniProtKB/Swiss-Prot
      Q9BQF6
      Related
      ENSP00000377651.1, ENST00000394091.5
      Conserved Domains (1) summary
      cl23802
      Location:610 → 847
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    5. NM_001282804.2 → NP_001269733.1  sentrin-specific protease 7 isoform 6

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in its 5' UTR, initiates translation at a downstream start codon, lacks several exons, and its 3'-terminal exon extends past a splice site that is used in variant 1. The encoded isoform (6) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AA651903, AL136599, BC129988, BU619557
      UniProtKB/Swiss-Prot
      Q9BQF6

    6. NM_020654.5 → NP_065705.3  sentrin-specific protease 7 isoform 1

      See identical proteins and their annotated locations for NP_065705.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as SENP7L) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI858732, AL136599, BC129988
      Consensus CDS
      CCDS2941.2
      UniProtKB/Swiss-Prot
      A1L3A5, A8MW39, B7WNW8, Q7Z3F4, Q96PS5, Q9BQF6, Q9C0F6, Q9HBT5
      Related
      ENSP00000377655.2, ENST00000394095.7
      Conserved Domains (1) summary
      cl23802
      Location:774 → 1011
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      101324205..101513212 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017006926.2 → XP_016862415.1  sentrin-specific protease 7 isoform X8

    2. XM_047448627.1 → XP_047304583.1  sentrin-specific protease 7 isoform X6

    3. XM_005247662.6 → XP_005247719.1  sentrin-specific protease 7 isoform X5

      Conserved Domains (1) summary
      cl23802
      Location:643 → 880
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    4. XM_011513042.4 → XP_011511344.1  sentrin-specific protease 7 isoform X4

      Conserved Domains (1) summary
      cl23802
      Location:644 → 881
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    5. XM_011513041.4 → XP_011511343.1  sentrin-specific protease 7 isoform X3

      Conserved Domains (1) summary
      cl23802
      Location:709 → 946
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    6. XM_011513040.4 → XP_011511342.1  sentrin-specific protease 7 isoform X2

      Conserved Domains (1) summary
      cl23802
      Location:710 → 947
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    7. XM_011513038.4 → XP_011511340.1  sentrin-specific protease 7 isoform X1

      Conserved Domains (1) summary
      cl23802
      Location:775 → 1012
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    8. XM_047448628.1 → XP_047304584.1  sentrin-specific protease 7 isoform X7

    9. XM_017006928.3 → XP_016862417.1  sentrin-specific protease 7 isoform X7

      UniProtKB/TrEMBL
      B4DM92
      Conserved Domains (1) summary
      cl23802
      Location:775 → 816
      Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain

    10. XM_011513045.4 → XP_011511347.1  sentrin-specific protease 7 isoform X9

    RNA

    1. XR_007095714.1 RNA Sequence

    2. XR_007095713.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      104030073..104219481 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347366.1 → XP_054203341.1  sentrin-specific protease 7 isoform X8

    2. XM_054347363.1 → XP_054203338.1  sentrin-specific protease 7 isoform X6

    3. XM_054347362.1 → XP_054203337.1  sentrin-specific protease 7 isoform X5

    4. XM_054347361.1 → XP_054203336.1  sentrin-specific protease 7 isoform X4

    5. XM_054347360.1 → XP_054203335.1  sentrin-specific protease 7 isoform X3

    6. XM_054347359.1 → XP_054203334.1  sentrin-specific protease 7 isoform X2

    7. XM_054347358.1 → XP_054203333.1  sentrin-specific protease 7 isoform X1

    8. XM_054347365.1 → XP_054203340.1  sentrin-specific protease 7 isoform X7

    9. XM_054347364.1 → XP_054203339.1  sentrin-specific protease 7 isoform X7

    10. XM_054347367.1 → XP_054203342.1  sentrin-specific protease 7 isoform X9

    RNA

    1. XR_008486767.1 RNA Sequence

    2. XR_008486766.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9BQF6.4 GenPept UniProtKB/Swiss-Prot:Q9BQF6

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