IL31RA interleukin 31 receptor A [Homo sapiens (human)] - Gene

Summary

Official Symbol: IL31RAprovided by HGNC
Official Full Name: interleukin 31 receptor Aprovided by HGNC
Primary source: HGNC:HGNC:18969
See related: Ensembl:ENSG00000164509 MIM:609510; AllianceGenome:HGNC:18969
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CRL; GPL; CRL3; GLMR; GLM-R; PLCA2; hGLM-R; IL-31RA; PRO21384; zcytoR17
Summary: The protein encoded by this gene belongs to the type I cytokine receptor family. This receptor, with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. It functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR). Several alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]
Expression: Low expression observed in reference dataset See more
Orthologs: mouse all
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Genomic context

Location:: 5q11.2

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (55839789..55922850)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (56668079..56751259)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (55147185..55218678)

Chromosome 5 - NC_000005.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interleukin 31 receptor alpha promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma.
Title: Interleukin 31 receptor α promotes smooth muscle cell contraction and airway hyperresponsiveness in asthma.
IL-31 and IL-31 receptor alpha in pemphigus: Contributors to more than just itch?
Title: IL-31 and IL-31 receptor alpha in pemphigus: Contributors to more than just itch?
Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis.
Title: Interleukin-31 promotes fibrosis and T helper 2 polarization in systemic sclerosis.
Feline Interleukin-31 Shares Overlapping Epitopes with the Oncostatin M Receptor and IL-31RA.
Title: Feline Interleukin-31 Shares Overlapping Epitopes with the Oncostatin M Receptor and IL-31RA.
The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity.
Title: The IL-31/IL-31 receptor axis: general features and role in tumor microenvironment.
The interleukin IL-31/IL-31receptor axis contributes to tumor growth in human follicular lymphoma.
Title: The interleukin (IL)-31/IL-31R axis contributes to tumor growth in human follicular lymphoma.
detected in keratinocytes and nerve fibers in the dermis of atopic dermatitis and in the neurons of normal dorsal root ganglia
Title: Distribution of IL-31 and its receptor expressing cells in skin of atopic dermatitis.
IL31RA is a functional receptor expressed by a small subpopulation of IL-31RA(+)/TRPV1(+)/TRPA1(+) neurons and is a critical neuroimmune link between TH2 cells and sensory nerves for the generation of T cell-mediated itch.
Title: A sensory neuron-expressed IL-31 receptor mediates T helper cell-dependent itch: Involvement of TRPV1 and TRPA1.
IL-31 and IL-31RA are upregulated in patients with allergic rhinitis, and induce MUC5AC gene expression in human airway epithelial cells.
Title: Effects of interleukin-31 on MUC5AC gene expression in nasal allergic inflammation.
IFN-gamma-induced IL-31RA upregulation in dermal microvascular endothelium is processed via JNK and PI3 kinase activation
Title: Interferon-γ induces upregulation and activation of the interleukin-31 receptor in human dermal microvascular endothelial cells.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Amyloidosis, primary localized cutaneous, 2 MedGen: C3151404 OMIM: 613955 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vif	vif	HIV-1 Vif modulates the expression of interleukin 31 receptor A (IL31RA) in Vif-expression T cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

SGC44558 (e-PCR)
- UniSTS:4635

G16909 (e-PCR)
- UniSTS:78686

D1S1423 (e-PCR)
- UniSTS:149619

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cytokine binding	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine binding	NAS Non-traceable Author Statement more info	PubMed
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	TAS Traceable Author Statement more info	PubMed
enables protein kinase binding	NAS Non-traceable Author Statement more info	PubMed
enables transcription coactivator activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in MAPK cascade	NAS Non-traceable Author Statement more info	PubMed
involved_in acute inflammatory response to antigenic stimulus	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor protein tyrosine kinase signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IEP Inferred from Expression Pattern more info	PubMed
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cytokine-mediated signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in defense response	NAS Non-traceable Author Statement more info	PubMed
involved_in defense response to other organism	IEA Inferred from Electronic Annotation more info
involved_in glandular epithelial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in homeostatic process	NAS Non-traceable Author Statement more info	PubMed
involved_in macrophage differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in monocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of apoptotic process	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of macrophage activation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of tyrosine phosphorylation of STAT protein	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in presynaptic membrane	IEA Inferred from Electronic Annotation more info
part_of receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: interleukin-31 receptor subunit alpha

Names: IL-31 receptor subunit alpha; IL-31R subunit alpha; class I cytokine receptor; cytokine receptor-like 3; gp130-like monocyte receptor; soluble type I cytokine receptor CRL3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_029436.2 RefSeqGene

Range

16570..88063

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001242636.2 → NP_001229565.1 interleukin-31 receptor subunit alpha isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC008914

Consensus CDS

CCDS75245.1

UniProtKB/TrEMBL

A0A494C190

Related

ENSP00000297015.4, ENST00000297015.7

Conserved Domains (3) summary

smart00060
Location:434 → 514

FN3; Fibronectin type 3 domain

cd00063
Location:136 → 235

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:38 → 132

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001242637.2 → NP_001229566.1 interleukin-31 receptor subunit alpha isoform 3

Status: REVIEWED

Source sequence(s)

AC008914, AK297938, AY358740, AY499339

Consensus CDS

CCDS56365.1

UniProtKB/TrEMBL

A0A494C190

Related

ENSP00000351935.5, ENST00000359040.10

Conserved Domains (3) summary

smart00060
Location:453 → 533

FN3; Fibronectin type 3 domain

cd00063
Location:155 → 254

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:57 → 151

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001242638.2 → NP_001229567.1 interleukin-31 receptor subunit alpha isoform 4 precursor

See identical proteins and their annotated locations for NP_001229567.1

Status: REVIEWED

Source sequence(s)

AC008914, AK297938, AY358740, AY499341, AY499342

Consensus CDS

CCDS56366.1

UniProtKB/TrEMBL

A0A494C190

Related

ENSP00000347047.4, ENST00000354961.8

Conserved Domains (3) summary

smart00060
Location:434 → 514

FN3; Fibronectin type 3 domain

cd00063
Location:136 → 235

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:38 → 132

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001242639.2 → NP_001229568.1 interleukin-31 receptor subunit alpha isoform 5

See identical proteins and their annotated locations for NP_001229568.1

Status: REVIEWED

Source sequence(s)

AC008914

Consensus CDS

CCDS56367.1

UniProtKB/TrEMBL

A0A494C190

Related

ENSP00000427533.1, ENST00000490985.5

Conserved Domains (2) summary

smart00060
Location:311 → 391

FN3; Fibronectin type 3 domain

cd00063
Location:13 → 112

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_001297570.3 → NP_001284499.1 interleukin-31 receptor subunit alpha isoform 6

See identical proteins and their annotated locations for NP_001284499.1

Status: REVIEWED

Source sequence(s)

AC008914

Consensus CDS

CCDS75244.1

Related

ENSP00000380048.2, ENST00000396836.6

Conserved Domains (2) summary

cd00063
Location:155 → 254

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:57 → 151

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
NM_139017.7 → NP_620586.3 interleukin-31 receptor subunit alpha isoform 1

See identical proteins and their annotated locations for NP_620586.3

Status: REVIEWED

Source sequence(s)

AC008914

Consensus CDS

CCDS3970.2

UniProtKB/TrEMBL

A0A494C190

Related

ENSP00000498630.1, ENST00000652347.2

Conserved Domains (3) summary

smart00060
Location:453 → 533

FN3; Fibronectin type 3 domain

cd00063
Location:155 → 254

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:59 → 142

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000005.10 Reference GRCh38.p14 Primary Assembly

Range

55839789..55922850

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011543142.3 → XP_011541444.1 interleukin-31 receptor subunit alpha isoform X1

See identical proteins and their annotated locations for XP_011541444.1

UniProtKB/Swiss-Prot

A6NIF8, Q2TBA1, Q6EBC3, Q6EBC4, Q6EBC5, Q6EBC6, Q6UWL8, Q8NI17, Q8WYJ0

UniProtKB/TrEMBL

A0A494C190

Conserved Domains (3) summary

smart00060
Location:421 → 501

FN3; Fibronectin type 3 domain

cd00063
Location:123 → 222

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cl21522
Location:25 → 119

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
XM_047416701.1 → XP_047272657.1 interleukin-31 receptor subunit alpha isoform X4
XM_047416700.1 → XP_047272656.1 interleukin-31 receptor subunit alpha isoform X2
XM_011543145.2 → XP_011541447.1 interleukin-31 receptor subunit alpha isoform X3

Conserved Domains (2) summary

smart00060
Location:283 → 363

FN3; Fibronectin type 3 domain

cd00063
Location:2 → 84

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

Alternate T2T-CHM13v2.0

Genomic

NC_060929.1 Alternate T2T-CHM13v2.0

Range

56668079..56751259

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054351572.1 → XP_054207547.1 interleukin-31 receptor subunit alpha isoform X1

UniProtKB/Swiss-Prot

A6NIF8, Q2TBA1, Q6EBC3, Q6EBC4, Q6EBC5, Q6EBC6, Q6UWL8, Q8NI17, Q8WYJ0
XM_054351575.1 → XP_054207550.1 interleukin-31 receptor subunit alpha isoform X4
XM_054351573.1 → XP_054207548.1 interleukin-31 receptor subunit alpha isoform X2
XM_054351574.1 → XP_054207549.1 interleukin-31 receptor subunit alpha isoform X3

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001297572.2: Suppressed sequence

Description

NM_001297572.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.