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    CG4238 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33377, updated on 4-Jan-2025

    Summary

    Official Symbol
    CG4238provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0031384
    Locus tag
    Dmel_CG4238
    See related
    AllianceGenome:FB:FBgn0031384
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG4238
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in negative regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Predicted to be active in cytosol. Is expressed in adult head. Orthologous to human AREL1 (apoptosis resistant E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
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    Genomic context

    See CG4238 in Genome Data Viewer
    Location:
    22B8-22C1; 2-3 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2009859..2030788)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2009859..2030788)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene transfer RNA:Glutamine-CTG 2-2 Neighboring gene transfer RNA:Glutamine-CTG 2-3 Neighboring gene transfer RNA:Glutamine-CTG 2-4 Neighboring gene transfer RNA:Glutamine-CTG 3-1 Neighboring gene transfer RNA:Glutamine-CTG 2-5 Neighboring gene snoRNA:Orphan C/D box 14 Neighboring gene transfer RNA:Glycine-GCC 1-2 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Interactions

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity  
    enables ubiquitin-protein transferase activity  
    enables ubiquitin-protein transferase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    is_active_in cytosol  
    located_in cytosol  

    General protein information

    Preferred Names
    uncharacterized protein
    Names
    CG4238-PD
    CG4238-PE
    CG4238-PF
    CG4238-PG
    CG4238-PH
    CG4238-PI
    CG4238-PJ

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2009859..2030788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001103583.3 → NP_001097053.2  uncharacterized protein Dmel_CG4238, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097053.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT2, Q8MZA5
      Conserved Domains (6) summary
      smart00454
      Location:41 → 99
      SAM; Sterile alpha motif
      smart00119
      Location:633 → 965
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:229 → 327
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:606 → 966
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:229 → 327
      Filamin; Filamin/ABP280 repeat
      cl15755
      Location:44 → 73
      SAM_superfamily; SAM (Sterile alpha motif )
    2. NM_001272966.1 → NP_001259895.1  uncharacterized protein Dmel_CG4238, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259895.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PE16, Q8MZA5
      Conserved Domains (6) summary
      smart00454
      Location:41 → 99
      SAM; Sterile alpha motif
      smart00119
      Location:627 → 959
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:229 → 327
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:600 → 960
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:229 → 327
      Filamin; Filamin/ABP280 repeat
      cl15755
      Location:44 → 73
      SAM_superfamily; SAM (Sterile alpha motif )
    3. NM_001272965.1 → NP_001259894.1  uncharacterized protein Dmel_CG4238, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259894.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT3, Q8MZA5
      Conserved Domains (4) summary
      smart00119
      Location:593 → 925
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:189 → 287
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:566 → 926
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:189 → 287
      Filamin; Filamin/ABP280 repeat
    4. NM_001272968.1 → NP_001259897.1  uncharacterized protein Dmel_CG4238, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259897.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT3, Q8MZA5
      Conserved Domains (4) summary
      smart00119
      Location:593 → 925
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:189 → 287
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:566 → 926
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:189 → 287
      Filamin; Filamin/ABP280 repeat
    5. NM_001103582.2 → NP_001097052.2  uncharacterized protein Dmel_CG4238, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097052.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A8DYT3, Q8MZA5
      Conserved Domains (4) summary
      smart00119
      Location:593 → 925
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:189 → 287
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:566 → 926
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:189 → 287
      Filamin; Filamin/ABP280 repeat
    6. NM_001272967.1 → NP_001259896.1  uncharacterized protein Dmel_CG4238, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259896.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ67
      Conserved Domains (4) summary
      smart00119
      Location:642 → 974
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:238 → 336
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:615 → 975
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:238 → 336
      Filamin; Filamin/ABP280 repeat
    7. NM_134796.4 → NP_608640.2  uncharacterized protein Dmel_CG4238, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_608640.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VQ67
      Conserved Domains (4) summary
      smart00119
      Location:642 → 974
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      smart00557
      Location:238 → 336
      IG_FLMN; Filamin-type immunoglobulin domains
      cd00078
      Location:615 → 975
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam00630
      Location:238 → 336
      Filamin; Filamin/ABP280 repeat
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