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    Alg5 ALG5 dolichyl-phosphate beta-glucosyltransferase [ Mus musculus (house mouse) ]

    Gene ID: 66248, updated on 2-Nov-2024

    Summary

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    Official Symbol
    Alg5provided by MGI
    Official Full Name
    ALG5 dolichyl-phosphate beta-glucosyltransferaseprovided by MGI
    Primary source
    MGI:MGI:1913498
    See related
    Ensembl:ENSMUSG00000036632 AllianceGenome:MGI:1913498
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1500026A19Rik; 2600005J22Rik
    Summary
    Predicted to enable dolichyl-phosphate beta-glucosyltransferase activity. Acts upstream of or within determination of left/right symmetry. Predicted to be active in cytoplasmic side of rough endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in polycystic kidney disease 7. Orthologous to human ALG5 (ALG5 dolichyl-phosphate beta-glucosyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in placenta adult (RPKM 25.9), bladder adult (RPKM 13.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Alg5 in Genome Data Viewer
    Location:
    3 C; 3 25.6 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (54642960..54657216)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (54735539..54749795)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene REX1, RNA exonuclease 1 homolog pseudogene Neighboring gene STARR-seq mESC enhancer starr_07679 Neighboring gene STARR-positive B cell enhancer ABC_E8986 Neighboring gene STARR-seq mESC enhancer starr_07681 Neighboring gene SPT20 SAGA complex component Neighboring gene STARR-positive B cell enhancer ABC_E7912 Neighboring gene STARR-positive B cell enhancer ABC_E10181 Neighboring gene exosome component 8 Neighboring gene SMAD family member 9 Neighboring gene STARR-seq mESC enhancer starr_07686 Neighboring gene regulatory factor X-associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Analysis of mouse embryonic patterning and morphogenesis by forward genetics. García-García MJ, et al. Proc Natl Acad Sci U S A, 2005 Apr 26. PMID 15755804, Free PMC Article
    2. Viral Infection-Induced Differential Expression of LncRNAs Associated with Collagen in Mouse Placentas and Amniotic Sacs. Pan J, et al. Am J Reprod Immunol, 2015 Sep. PMID 26073538
    3. Functional genomic landscape of cancer-intrinsic evasion of killing by T cells. Lawson KA, et al. Nature, 2020 Oct. PMID 32968282, Free PMC Article
    4. Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors. Kim H, et al. Cell, 2018 Dec 13. PMID 30550785, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables dolichyl-phosphate beta-glucosyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables dolichyl-phosphate beta-glucosyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in dolichol-linked oligosaccharide biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dolichol-linked oligosaccharide biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein N-linked glycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein N-linked glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein N-linked glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasmic side of rough endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasmic side of rough endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    dolichyl-phosphate beta-glucosyltransferase
    Names
    Alg5 homolog
    asparagine-linked glycosylation 5 (dolichyl-phosphate beta-glucosyltransferase)
    asparagine-linked glycosylation 5 homolog (yeast, dolichyl-phosphate beta-glucosyltransferase)
    asparagine-linked glycosylation protein 5 homolog
    dolP-glucosyltransferase
    NP_079718.1
    XP_036019115.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025442.3 → NP_079718.1  dolichyl-phosphate beta-glucosyltransferase

      See identical proteins and their annotated locations for NP_079718.1

      Status: VALIDATED

      Source sequence(s)
      AC100927
      Consensus CDS
      CCDS17353.1
      UniProtKB/Swiss-Prot
      Q9DB25
      UniProtKB/TrEMBL
      Q9CTE8
      Related
      ENSMUSP00000035879.4, ENSMUST00000044567.4
      Conserved Domains (1) summary
      cd04188
      Location:69 → 289
      DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      54642960..54657216
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036163222.1 → XP_036019115.1  dolichyl-phosphate beta-glucosyltransferase isoform X1

      UniProtKB/TrEMBL
      Q9CTE8
      Conserved Domains (1) summary
      cd04188
      Location:52 → 272
      DPG_synthase; DPG_synthase is involved in protein N-linked glycosylation
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DB25.1 GenPept UniProtKB/Swiss-Prot:Q9DB25

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