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    gag-abl p120 Gag-Abl polyprotein [ Abelson murine leukemia virus ]

    Gene ID: 1491873, updated on 29-Jul-2022

    Summary

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    Gene symbol
    gag-abl
    Gene description
    p120 Gag-Abl polyprotein
    Locus tag
    AbMLVgp1
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Abelson murine leukemia virus
    Lineage
    Viruses; Retro-transcribing viruses; Retroviridae; Orthoretrovirinae; Gammaretrovirus; unclassified Gammaretrovirus
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    Genomic context

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    Sequence:
    NC_001499.1 (621..3566)

    NC_001499.1Genomic Context describing neighboring genes

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001499.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Gag influences transformation by Abelson murine leukemia virus and suppresses nuclear localization of the v-Abl protein. Yi CR, et al. J Virol, 2007 Sep. PMID 17596313, Free PMC Article
    2. SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus. Fessler SP, et al. J Virol, 2011 Sep. PMID 21697469, Free PMC Article
    3. Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV. Yi CR, et al. J Virol, 2008 Jun. PMID 18367522, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The data show that reduction of SHIP protein by v-Abl is a critical component in Abelson murine leukemia virus transformation.
      Title: SH2-containing inositol 5'-phosphatase inhibits transformation of Abelson murine leukemia virus.
    2. MA sequences within the Gag moiety of the v-Abl protein contribute to proper localization by playing a dominant role in trafficking of the v-Abl molecule
      Title: Mutations affecting the MA portion of the v-Abl protein reveal a conserved role of Gag in Abelson murine leukemia virus (MLV) and Moloney MLV.
    3. These data indicate that Gag sequences are important for normal v-Abl signaling and that they suppress nuclear localization of the molecule.
      Title: Gag influences transformation by Abelson murine leukemia virus and suppresses nuclear localization of the v-Abl protein.
    Submit: New GeneRIF Correction

    General gene information

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    misc_recomb

    • Loc: 1330-1331

    General protein information

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    Preferred Names
    p120 Gag-Abl polyprotein
    Names
    MA
    CA
    ABL

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001499.1 Reference assembly

      Range
      621..3566
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_057866.1 p120 Gag-Abl polyprotein [Abelson murine leukemia virus]

      See identical proteins and their annotated locations for NP_057866.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O39477, O92809
      Conserved Domains (6) summary
      smart00808
      Location:857 → 981
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:244 → 337
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd05052
      Location:356 → 618
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam01140
      Location:2 → 126
      Gag_MA; Matrix protein (MA), p15
      pfam01141
      Location:132 → 215
      Gag_p12; Gag polyprotein, inner coat protein p12
      pfam07714
      Location:363 → 614
      Pkinase_Tyr; Protein tyrosine kinase

    2. NP_955593.1 MA

      Conserved Domains (1) summary
      pfam01140
      Location:1 → 125
      Gag_MA; Matrix protein (MA), p15

    3. NP_955594.1 CA

      Conserved Domains (1) summary
      pfam01141
      Location:1 → 84
      Gag_p12; Gag polyprotein, inner coat protein p12

    4. NP_955595.1 ABL

      UniProtKB/Swiss-Prot
      P00521
      Conserved Domains (4) summary
      smart00808
      Location:622 → 746
      FABD; F-actin binding domain (FABD)
      cd09935
      Location:9 → 102
      SH2_ABL; Src homology 2 (SH2) domain found in Abelson murine lymphosarcoma virus (ABL) proteins
      cd05052
      Location:121 → 383
      PTKc_Abl; Catalytic domain of the Protein Tyrosine Kinase, Abelson kinase
      pfam07714
      Location:128 → 379
      Pkinase_Tyr; Protein tyrosine kinase
    Nucleotide Protein
    Heading Accession and Version

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