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    nck1a NCK adaptor protein 1a [ Danio rerio (zebrafish) ]

    Gene ID: 564584, updated on 2-Nov-2024

    Summary

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    Official Symbol
    nck1aprovided by ZNC
    Official Full Name
    NCK adaptor protein 1aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-070912-547
    See related
    Ensembl:ENSDARG00000074262 AllianceGenome:ZFIN:ZDB-GENE-070912-547
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    si:dkey-4m11.4
    Summary
    Predicted to enable ephrin receptor binding activity; receptor tyrosine kinase binding activity; and signaling adaptor activity. Predicted to be involved in several processes, including ephrin receptor signaling pathway; positive regulation of translation in response to endoplasmic reticulum stress; and regulation of response to endoplasmic reticulum stress. Predicted to be active in cytoplasm. Is expressed in female organism. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Nov 2024]
    Orthologs
    all
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    Genomic context

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    See nck1a in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (24963861..24981356, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (25308227..25325770, complement)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene angiotensin II receptor, type 1a Neighboring gene glycogenin 1a Neighboring gene helicase-like transcription factor Neighboring gene solute carrier family 35 member G2a Neighboring gene STAG1 cohesin complex component a Neighboring gene propionyl-CoA carboxylase subunit beta

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Surprising conservation of schizophrenia risk genes in lower organisms reflects their essential function and the evolution of genetic liability. Kasap M, et al. Schizophr Res, 2018 Dec. PMID 30017463
    2. CRK and NCK adaptors may functionally overlap in zebrafish neurodevelopment, as indicated by common binding partners and overlapping expression patterns. Stergas HR, et al. FEBS Lett, 2024 Feb. PMID 38058169
    3. On the crucial cerebellar wound healing-related pathways and their cross-talks after traumatic brain injury in Danio rerio. Wu CC, et al. PLoS One, 2014. PMID 24926785, Free PMC Article
    4. Phenotypic Landscape of Schizophrenia-Associated Genes Defines Candidates and Their Shared Functions. Thyme SB, et al. Cell, 2019 Apr 4. PMID 30929901, Free PMC Article
    5. Brain transcriptome analysis of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Newman M, et al. Mol Brain, 2019 May 3. PMID 31053140, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    General protein information

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    Preferred Names
    SH2/SH3 adapter protein Nck1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      24963861..24981356 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_687914.7 → XP_693006.3  SH2/SH3 adapter protein Nck1

      UniProtKB/TrEMBL
      A0A8N7TBD0
      Related
      ENSDARP00000102138.3, ENSDART00000111212.4
      Conserved Domains (3) summary
      cd11901
      Location:42 → 96
      SH3_Nck1_2; Second Src Homology 3 domain of Nck1 adaptor protein
      cl15255
      Location:213 → 309
      SH2; Src homology 2 (SH2) domain
      cl17036
      Location:126 → 182
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version

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