nppa natriuretic peptide A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: nppaprovided by ZNC
Official Full Name: natriuretic peptide Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-95
See related: Ensembl:ENSDARG00000052960 AllianceGenome:ZFIN:ZDB-GENE-030131-95
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: anf; anp; zeh1304; hm:zeh1304
Summary: Predicted to enable hormone activity and hormone receptor binding activity. Acts upstream of or within atrioventricular canal development; cardiac jelly development; and cardiac muscle cell proliferation. Predicted to be located in extracellular region. Predicted to be active in cytoplasm; extracellular space; and nucleus. Is expressed in heart rudiment; pericardial region; and skeletal muscle cell. Human ortholog(s) of this gene implicated in artery disease (multiple); congestive heart failure; heart conduction disease (multiple); and peritonitis. Orthologous to human NPPA (natriuretic peptide A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 8

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	8	NC_007119.7 (48613033..48617665)
105	previous assembly	GRCz10 (GCF_000002035.5)	8	NC_007119.6 (48624264..48628896)

Chromosome 8 - NC_007119.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Upon cardiac stress, Nppa and Nppb are strongly upregulated in the ventricular myocardium. (Review)
Title: Structure and function of the Nppa-Nppb cluster locus during heart development and disease.
This paper definitively shows that nppa and nppb function redundantly during cardiac development to restrict gene expression to the atrioventricular canal, preventing excessive cardiac jelly synthesis in the atrial chamber.
Title: Nppa and Nppb act redundantly during zebrafish cardiac development to confine AVC marker expression and reduce cardiac jelly volume.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within atrioventricular canal development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel diameter maintenance	IEA Inferred from Electronic Annotation more info
involved_in cGMP biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in cGMP-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cardiac jelly development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within cardiac muscle cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of systemic arterial blood pressure	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: natriuretic peptides A

Names: atrial natriuretic factor; natriuretic peptide precursor A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_198800.3 → NP_942095.2 natriuretic peptides A precursor

Status: VALIDATED

Source sequence(s)

BX323876

UniProtKB/TrEMBL

A0A8M1PDR2, F1QVW0

Related

ENSDARP00000108691.2, ENSDART00000121432.3

Conserved Domains (1) summary

pfam00212
Location:116 → 134

ANP; Atrial natriuretic peptide