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    ZNF92 zinc finger protein 92 [ Homo sapiens (human) ]

    Gene ID: 168374, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF92provided by HGNC
    Official Full Name
    zinc finger protein 92provided by HGNC
    Primary source
    HGNC:HGNC:13168
    See related
    Ensembl:ENSG00000146757 MIM:603974; AllianceGenome:HGNC:13168
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TF12; HPF12; HTF12; HEL-203
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 2.6), bone marrow (RPKM 2.5) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF92 in Genome Data Viewer
    Location:
    7q11.21
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (65373855..65401136)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (66584340..66611618)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (64838768..64866049)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105375334 Neighboring gene ribosomal L24 domain containing 1 pseudogene 3 Neighboring gene zinc finger protein 737 pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:64838633-64838903 Neighboring gene MPRA-validated peak6540 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr7:64905072-64905245 Neighboring gene uncharacterized LOC124901660 Neighboring gene integrator complex subunit 4 pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:64974100-64975098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:64997202-64997702 Neighboring gene uncharacterized LOC124901800

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The evolutionarily conserved Krüppel-associated box domain defines a subfamily of eukaryotic multifingered proteins. Bellefroid EJ, et al. Proc Natl Acad Sci U S A, 1991 May 1. PMID 2023909, Free PMC Article
    2. Clustered organization of homologous KRAB zinc-finger genes with enhanced expression in human T lymphoid cells. Bellefroid EJ, et al. EMBO J, 1993 Apr. PMID 8467795, Free PMC Article
    3. HENA, heterogeneous network-based data set for Alzheimer's disease. Sügis E, et al. Sci Data, 2019 Aug 14. PMID 31413325, Free PMC Article
    4. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article
    5. Generation and analysis of 280,000 human expressed sequence tags. Hillier LD, et al. Genome Res, 1996 Sep. PMID 8889549

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
      Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
    2. Observational study of gene-disease association. (HuGE Navigator)
      Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
    3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 92
    Names
    epididymis luminal protein 203
    zinc finger protein HTF12

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001287532.2 → NP_001274461.1  zinc finger protein 92 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 5' coding region, compared to variant 2. It encodes isoform 3, which is shorter than isoform 2.
      Source sequence(s)
      AC092685, BC040594, BP284170, BX647875, DA939471, DB342562, T52873
      Consensus CDS
      CCDS75608.1
      UniProtKB/Swiss-Prot
      Q03936
      Related
      ENSP00000350113.2, ENST00000357512.3
      Conserved Domains (3) summary
      COG5048
      Location:195 → 547
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:171 → 191
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:3 → 43
      KRAB; KRAB box

    2. NM_001287533.2 → NP_001274462.1  zinc finger protein 92 isoform 4

      See identical proteins and their annotated locations for NP_001274462.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 4 and 5 encode the same isoform (4), which is shorter at the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC092685, BC040594, BP284170, BX647875, DB342562, T52873
      Consensus CDS
      CCDS75609.1
      UniProtKB/TrEMBL
      C9IZS8
      Conserved Domains (3) summary
      COG5048
      Location:151 → 503
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:127 → 147
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:308 → 332
      zf-H2C2_2; Zinc-finger double domain

    3. NM_001287534.2 → NP_001274463.1  zinc finger protein 92 isoform 4

      See identical proteins and their annotated locations for NP_001274463.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start codon, compared to variant 2. Variants 4 and 5 encode the same isoform (4), which is shorter at the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC092685, BC040594, BX647875, DA637374, DB342562, T52873
      Consensus CDS
      CCDS75609.1
      UniProtKB/TrEMBL
      C9IZS8
      Related
      ENSP00000400495.1, ENST00000431504.1
      Conserved Domains (3) summary
      COG5048
      Location:151 → 503
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:127 → 147
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:308 → 332
      zf-H2C2_2; Zinc-finger double domain

    4. NM_007139.4 → NP_009070.2  zinc finger protein 92 isoform 1

      See identical proteins and their annotated locations for NP_009070.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 2. It encodes isoform 1, which is shorter at the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC092685, BC040594, BP284170, BX647875, DA397874, DB342562, T52873
      Consensus CDS
      CCDS47596.1
      UniProtKB/Swiss-Prot
      Q03936
      Related
      ENSP00000396126.2, ENST00000450302.2
      Conserved Domains (3) summary
      COG5048
      Location:158 → 510
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:134 → 154
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:315 → 339
      zf-H2C2_2; Zinc-finger double domain

    5. NM_152626.4 → NP_689839.1  zinc finger protein 92 isoform 2

      See identical proteins and their annotated locations for NP_689839.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AC092685, BC040594, BP284170, BX647875, DB342562, T52873
      Consensus CDS
      CCDS34646.1
      UniProtKB/Swiss-Prot
      A6NNF9, Q03936, Q8N492, Q8NB35
      UniProtKB/TrEMBL
      V9HVY7
      Related
      ENSP00000332595.8, ENST00000328747.12
      Conserved Domains (5) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:227 → 579
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:203 → 223
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:384 → 408
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      65373855..65401136
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      66584340..66611618
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q03936.2 GenPept UniProtKB/Swiss-Prot:Q03936

    Gene LinkOut

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