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    TAGLN2 transgelin 2 [ Homo sapiens (human) ]

    Gene ID: 8407, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TAGLN2provided by HGNC
    Official Full Name
    transgelin 2provided by HGNC
    Primary source
    HGNC:HGNC:11554
    See related
    Ensembl:ENSG00000158710 MIM:604634; AllianceGenome:HGNC:11554
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HA1756
    Summary
    The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
    Expression
    Ubiquitous expression in lung (RPKM 268.8), stomach (RPKM 231.0) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TAGLN2 in Genome Data Viewer
    Location:
    1q23.2
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159918111..159925507, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (159055181..159062575, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159887901..159895297, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 45 Neighboring gene uncharacterized LOC124904435 Neighboring gene microRNA 4259 Neighboring gene Sharpr-MPRA regulatory regions 3039 and 8536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159882219-159882720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:159887707-159888596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1911 Neighboring gene uncharacterized LOC124904437 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:159893727-159894926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159904768-159905268 Neighboring gene immunoglobulin superfamily member 9 Neighboring gene uncharacterized LOC124904438 Neighboring gene Sharpr-MPRA regulatory region 11999 Neighboring gene SLAM family member 9 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Transgelin-2: Biochemical and Clinical Implications in Cancer and Asthma. Yin LM, et al. Trends Biochem Sci, 2019 Oct. PMID 31256982, Free PMC Article
    2. TAGLN2 is a candidate prognostic biomarker promoting tumorigenesis in human gliomas. Han MZ, et al. J Exp Clin Cancer Res, 2017 Nov 6. PMID 29110682, Free PMC Article
    3. Usefulness of material recovered from distal embolic protection devices after carotid angioplasty for proteomic studies. Cristobo I, et al. J Vasc Interv Radiol, 2012 Jun. PMID 22626270
    4. Transgelin-2 is a novel target of KRAS-ERK signaling involved in the development of pancreatic cancer. Sun Y, et al. J Exp Clin Cancer Res, 2018 Jul 24. PMID 30041673, Free PMC Article
    5. Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients. Szelenberger R, et al. Int J Mol Sci, 2022 Jun 6. PMID 35683019, Free PMC Article

    See all (178) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer.
      Title: TAGLN2 induces resistance signature ISGs by activating AKT-YBX1 signal with dual pathways and mediates the IFN-related DNA damage resistance in gastric cancer.
    2. Unveiling the role of TAGLN2 in glioblastoma: From proneural-mesenchymal transition to Temozolomide resistance.
      Title: Unveiling the role of TAGLN2 in glioblastoma: From proneural-mesenchymal transition to Temozolomide resistance.
    3. TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
      Title: TAGLN2 targeted control of ARPC5-mediated activation of the MEK/ERK signaling pathway influences the proliferation, invasion, and metastasis of pancreatic cancer cells.
    4. Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.
      Title: Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.
    5. TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
      Title: TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
    6. TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis.
      Title: TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis.
    7. Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients.
      Title: Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients.
    8. Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis.
      Title: Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis.
    9. Mechanisms of Transgelin-2 in Tumorigenesis.
      Title: Mechanisms of Transgelin-2 in Tumorigenesis.
    10. Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
      Title: Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
    Submit: New GeneRIF Correction See all GeneRIFs (35)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of transgelin 2 (TAGLN2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of transgelin-2 in umbilical cord blood mononuclear cells PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transgelin 2 (TAGLN2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA0120

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell differentiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    located_in vesicle HDA PubMed 

    General protein information

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    Preferred Names
    transgelin-2
    Names
    SM22-alpha homolog
    epididymis secretory sperm binding protein
    epididymis tissue protein Li 7e

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001277223.2 → NP_001264152.1  transgelin-2 isoform b

      See identical proteins and their annotated locations for NP_001264152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate first exon and begins translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AI270594, AK291562, AL513485, CF128621
      Consensus CDS
      CCDS1189.1
      UniProtKB/Swiss-Prot
      E9KL39, P37802, Q5JRQ6, Q5JRQ7, Q6FGI1, Q9BUH5, Q9H4P0
      UniProtKB/TrEMBL
      A0A384MTL2, X6RJP6
      Related
      ENSP00000357075.1, ENST00000320307.8
      Conserved Domains (2) summary
      pfam00402
      Location:174 → 198
      Calponin; Calponin family repeat
      cd21280
      Location:18 → 154
      CH_TAGLN2; calponin homology (CH) domain found in transgelin-2

    2. NM_001277224.2 → NP_001264153.1  transgelin-2 isoform a

      See identical proteins and their annotated locations for NP_001264153.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL513485, AY007127
      Consensus CDS
      CCDS60314.1
      UniProtKB/TrEMBL
      X6RJP6
      Related
      ENSP00000357076.1, ENST00000368096.5
      Conserved Domains (2) summary
      pfam00307
      Location:47 → 154
      CH; Calponin homology (CH) domain
      pfam00402
      Location:195 → 218
      Calponin; Calponin family repeat

    3. NM_003564.3 → NP_003555.1  transgelin-2 isoform b

      See identical proteins and their annotated locations for NP_003555.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate first exon and begins translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
      Source sequence(s)
      AI270594, AK291562
      Consensus CDS
      CCDS1189.1
      UniProtKB/Swiss-Prot
      E9KL39, P37802, Q5JRQ6, Q5JRQ7, Q6FGI1, Q9BUH5, Q9H4P0
      UniProtKB/TrEMBL
      A0A384MTL2, X6RJP6
      Related
      ENSP00000357077.5, ENST00000368097.9
      Conserved Domains (2) summary
      pfam00402
      Location:174 → 198
      Calponin; Calponin family repeat
      cd21280
      Location:18 → 154
      CH_TAGLN2; calponin homology (CH) domain found in transgelin-2

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      159918111..159925507 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      159055181..159062575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P37802.3 GenPept UniProtKB/Swiss-Prot:P37802

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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