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    GNL3 G protein nucleolar 3 [ Homo sapiens (human) ]

    Gene ID: 26354, updated on 3-Nov-2024

    Summary

    Official Symbol
    GNL3provided by HGNC
    Official Full Name
    G protein nucleolar 3provided by HGNC
    Primary source
    HGNC:HGNC:29931
    See related
    Ensembl:ENSG00000163938 MIM:608011; AllianceGenome:HGNC:29931
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS; Nug1; E2IG3; NNP47; C77032
    Summary
    The protein encoded by this gene may interact with p53 and may be involved in tumorigenesis. The encoded protein also appears to be important for stem cell proliferation. This protein is found in both the nucleus and nucleolus. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
    Expression
    Ubiquitous expression in urinary bladder (RPKM 35.8), prostate (RPKM 32.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GNL3 in Genome Data Viewer
    Location:
    3p21.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (52685920..52694497)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (52718831..52727408)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (52719936..52728513)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 856, pseudogene Neighboring gene RNA, U6atac small nuclear 16, pseudogene Neighboring gene polybromo 1 Neighboring gene MPRA-validated peak4655 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52699923-52700424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52700425-52700924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19944 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:52719523-52720211 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19945 Neighboring gene small nucleolar RNA, C/D box 136 Neighboring gene small nucleolar RNA, C/D box 19B Neighboring gene small nucleolar RNA, C/D box 19C Neighboring gene small nucleolar RNA, C/D box 19 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14451 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19946 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14452 Neighboring gene small nucleolar RNA, C/D box 69 Neighboring gene glycosyltransferase 8 domain containing 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:52749367-52749954 Neighboring gene signal peptidase complex subunit 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:52765581-52766780 Neighboring gene zinc finger protein 610 pseudogene Neighboring gene NIMA related kinase 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog
    Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
    EBI GWAS Catalog
    Genome-wide association of mood-incongruent psychotic bipolar disorder.
    EBI GWAS Catalog
    Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.
    EBI GWAS Catalog
    Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
    EBI GWAS Catalog
    Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human guanine nucleotide binding protein-like 3 (GNL3) at amino acid residues 509-510 by the HIV-1 protease PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC800

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables RNA binding HDA PubMed 
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in chromosome IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular space HDA PubMed 
    located_in membrane HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleolus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    guanine nucleotide-binding protein-like 3
    Names
    E2-induced gene 3 protein
    estradiol-induced nucleotide binding protein
    guanine nucleotide binding protein-like 3 (nucleolar)
    novel nucleolar protein 47
    nucleolar GTP-binding protein 3
    nucleostemin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027871.1 RefSeqGene

      Range
      5113..13578
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_014366.5NP_055181.3  guanine nucleotide-binding protein-like 3 isoform 1

      See identical proteins and their annotated locations for NP_055181.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AI028402, AK027514, BC001024, CF272475
      Consensus CDS
      CCDS2861.1
      UniProtKB/Swiss-Prot
      B2RDC1, Q5PU80, Q96SV6, Q96SV7, Q9BVP2, Q9UJY0
      Related
      ENSP00000395772.1, ENST00000418458.6
      Conserved Domains (3) summary
      cd04178
      Location:142307
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:133419
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      pfam08701
      Location:1685
      GN3L_Grn1; GNL3L/Grn1 putative GTPase
    2. NM_206825.2NP_996561.1  guanine nucleotide-binding protein-like 3 isoform 2

      See identical proteins and their annotated locations for NP_996561.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AF191018, AK027514
      Consensus CDS
      CCDS43100.1
      Related
      ENSP00000378278.2, ENST00000394799.6
      Conserved Domains (3) summary
      cd04178
      Location:130295
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:121407
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      pfam08701
      Location:473
      GN3L_Grn1; GNL3L/Grn1 putative GTPase
    3. NM_206826.1NP_996562.1  guanine nucleotide-binding protein-like 3 isoform 2

      See identical proteins and their annotated locations for NP_996562.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1. Variants 2 and 3 both encode the same isoform (2).
      Source sequence(s)
      AF191018, AK027514, BC001024, BF732788
      Consensus CDS
      CCDS43100.1
      Conserved Domains (3) summary
      cd04178
      Location:130295
      Nucleostemin_like; A circularly permuted subfamily of the Ras GTPases
      COG1161
      Location:121407
      RbgA; Ribosome biogenesis GTPase A [Translation, ribosomal structure and biogenesis]
      pfam08701
      Location:473
      GN3L_Grn1; GNL3L/Grn1 putative GTPase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      52685920..52694497
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      52718831..52727408
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)