U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    rab3gap2 RAB3 GTPase activating protein subunit 2 (non-catalytic) [ Danio rerio (zebrafish) ]

    Gene ID: 368905, updated on 28-Oct-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    rab3gap2provided by ZNC
    Official Full Name
    RAB3 GTPase activating protein subunit 2 (non-catalytic)provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030616-610
    See related
    Ensembl:ENSDARG00000044136 AllianceGenome:ZFIN:ZDB-GENE-030616-610
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    RAB3; RAB3GAP; wu:fb94b08; zgc:158161; si:zc214p16.5; si:ch211-214p16.5
    Summary
    Predicted to enable small GTPase binding activity. Predicted to contribute to enzyme regulator activity. Predicted to be involved in establishment of protein localization to endoplasmic reticulum membrane; macroautophagy; and synaptic signaling. Predicted to be located in cytoplasm. Predicted to be active in autophagosome and presynaptic membrane. Human ortholog(s) of this gene implicated in Martsolf syndrome and Warburg micro syndrome 2. Orthologous to human RAB3GAP2 (RAB3 GTPase activating non-catalytic protein subunit 2). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See rab3gap2 in Genome Data Viewer
    Location:
    chromosome: 17
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (25610350..25630837, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (25591960..25612469, complement)

    Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene si:ch211-214p16.2 Neighboring gene isoleucyl-tRNA synthetase 2, mitochondrial Neighboring gene protein phosphatase 1, catalytic subunit, beta isozyme Neighboring gene phospholipase B1

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Nxhl Controls Angiogenesis by Targeting VE-PTP Through Interaction With Nucleolin. Luo H, et al. Front Cell Dev Biol, 2021. PMID 34733844, Free PMC Article
    2. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article
    3. 15000 unique zebrafish EST clusters and their future use in microarray for profiling gene expression patterns during embryogenesis. Lo J, et al. Genome Res, 2003 Mar. PMID 12618376, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC158161

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to enzyme regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables small GTPase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of protein localization to endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in macroautophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synaptic signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in autophagosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    rab3 GTPase-activating protein non-catalytic subunit
    Names
    GTPase-activating

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004528.1 → NP_001004528.1  rab3 GTPase-activating protein non-catalytic subunit

      Status: PROVISIONAL

      Source sequence(s)
      AL929207
      UniProtKB/TrEMBL
      A0A8M1N224, Q7ZYZ0
      Related
      ENSDARP00000096276.2, ENSDART00000105503.4
      Conserved Domains (2) summary
      pfam14655
      Location:74 → 483
      RAB3GAP2_N; Rab3 GTPase-activating protein regulatory subunit N-terminus
      pfam14656
      Location:731 → 1247
      RAB3GAP2_C; Rab3 GTPase-activating protein regulatory subunit C-terminus

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007128.7 Reference GRCz11 Primary Assembly

      Range
      25610350..25630837 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017351602.3 → XP_017207091.1  rab3 GTPase-activating protein non-catalytic subunit isoform X2

      UniProtKB/TrEMBL
      A0A8M6YVK1, K7DYN0
      Related
      ENSDARP00000126559.1, ENSDART00000151878.2

    2. XM_017351601.3 → XP_017207090.1  rab3 GTPase-activating protein non-catalytic subunit isoform X1

      UniProtKB/TrEMBL
      A0A8M6YTS4
    Nucleotide Protein
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools