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    myh9a myosin, heavy chain 9a, non-muscle [ Danio rerio (zebrafish) ]

    Gene ID: 333938, updated on 17-Sep-2024

    Summary

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    Official Symbol
    myh9aprovided by ZNC
    Official Full Name
    myosin, heavy chain 9a, non-muscleprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-5870
    See related
    Ensembl:ENSDARG00000063295 AllianceGenome:ZFIN:ZDB-GENE-030131-5870
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    myh9; myh9l2; fi22c04; fj85e11; zgc:66164; wu:fi22c04; wu:fj85e11; zgc:162029
    Summary
    Predicted to enable ATP binding activity; actin filament binding activity; and cytoskeletal motor activity. Acts upstream of or within glomerular filtration and glomerulus development. Predicted to be part of myosin complex. Is expressed in several structures, including epidermis; nervous system; periderm; pronephric duct opening; and tail bud. Used to study kidney disease. Human ortholog(s) of this gene implicated in several diseases, including auditory system disease (multiple); autosomal dominant Alport syndrome; blood platelet disease (multiple); end stage renal disease; and orofacial cleft. Orthologous to human MYH9 (myosin heavy chain 9). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See myh9a in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 6 NC_007117.7 (7735806..7776609, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 6 NC_007117.6 (7578633..7619450, complement)

    Chromosome 6 - NC_007117.7Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA62/SNORA6 family Neighboring gene solute carrier family 25 member 38b Neighboring gene ribosomal protein SA Neighboring gene phospholipid phosphatase related 2b Neighboring gene paralemmin 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Non-muscle myosin IIA is required for the development of the zebrafish glomerulus. Müller T, et al. Kidney Int, 2011 Nov. PMID 21849970
    2. Stochastic contraction of myosin minifilaments drives evolution of microridge protrusion patterns in epithelial cells. van Loon AP, et al. Mol Biol Cell, 2021 Aug 1. PMID 34081537, Free PMC Article
    3. Simultaneous assessment of glomerular filtration and barrier function in live zebrafish. Kotb AM, et al. Am J Physiol Renal Physiol, 2014 Dec 15. PMID 25298528, Free PMC Article
    4. Nonmuscle myosin II-B (myh10) expression analysis during zebrafish embryonic development. Huang Y, et al. Gene Expr Patterns, 2013 Oct. PMID 23665442
    5. Non-muscle myosin IIA and IIB differentially regulate cell shape changes during zebrafish brain morphogenesis. Gutzman JH, et al. Dev Biol, 2015 Jan 1. PMID 25446029

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC66164, MGC162029

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within glomerular basement membrane development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerular capillary formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerular filtration IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerular filtration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within podocyte development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cortical granule IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    myosin-9a
    Names
    myosin heavy chain IX
    myosin, heavy chain 9, non-muscle, like-2
    myosin, heavy polypeptide 9, non-muscle
    myosin, heavy polypeptide 9a, non-muscle
    zNMHC-IIA

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001098177.2 → NP_001091647.2  myosin-9a

      See identical proteins and their annotated locations for NP_001091647.2

      Status: VALIDATED

      Source sequence(s)
      CR925711
      UniProtKB/TrEMBL
      A0A8M1NEM1
      Related
      ENSDARP00000124366.1, ENSDART00000149823.2
      Conserved Domains (6) summary
      cd14932
      Location:93 → 768
      MYSc_Myh18; class II myosin heavy chain 18, motor domain
      pfam00063
      Location:81 → 768
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:845 → 1925
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:28 → 66
      Myosin_N; Myosin N-terminal SH3-like domain
      cl23717
      Location:1067 → 1101
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      cl24005
      Location:1777 → 1878
      DUF2570; Protein of unknown function (DUF2570)

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007117.7 Reference GRCz11 Primary Assembly

      Range
      7735806..7776609 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005165695.5 → XP_005165752.1  myosin-9a isoform X2

      UniProtKB/TrEMBL
      A0A8M2BCY6
      Conserved Domains (5) summary
      cl22853
      Location:93 → 761
      Motor_domain; Myosin and Kinesin motor domain
      pfam00063
      Location:81 → 761
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:838 → 1918
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:28 → 66
      Myosin_N; Myosin N-terminal SH3-like domain
      cl24005
      Location:1770 → 1871
      DUF2570; Protein of unknown function (DUF2570)

    2. XM_005165694.5 → XP_005165751.1  myosin-9a isoform X1

      See identical proteins and their annotated locations for XP_005165751.1

      UniProtKB/TrEMBL
      A0A8M1NEM1
      Conserved Domains (6) summary
      cd14932
      Location:93 → 768
      MYSc_Myh18; class II myosin heavy chain 18, motor domain
      pfam00063
      Location:81 → 768
      Myosin_head; Myosin head (motor domain)
      pfam01576
      Location:845 → 1925
      Myosin_tail_1; Myosin tail
      pfam02736
      Location:28 → 66
      Myosin_N; Myosin N-terminal SH3-like domain
      cl23717
      Location:1067 → 1101
      crotonase-like; Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. ...
      cl24005
      Location:1777 → 1878
      DUF2570; Protein of unknown function (DUF2570)
    Nucleotide Protein Strain
    Heading Accession and Version

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