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    mark3a MAP/microtubule affinity-regulating kinase 3a [ Danio rerio (zebrafish) ]

    Gene ID: 334300, updated on 28-Oct-2024

    Summary

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    Official Symbol
    mark3aprovided by ZNC
    Official Full Name
    MAP/microtubule affinity-regulating kinase 3aprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-6232
    See related
    Ensembl:ENSDARG00000019345 AllianceGenome:ZFIN:ZDB-GENE-030131-6232
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    mark3; fi39g08; zgc:55693; wu:fi39g08; zgc:152848
    Summary
    Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction. Predicted to act upstream of or within protein phosphorylation. Predicted to be located in dendrite. Predicted to be active in cytoplasm and plasma membrane. Human ortholog(s) of this gene implicated in visual impairment and progressive phthisis bulbi. Orthologous to human MARK3 (microtubule affinity regulating kinase 3). [provided by Alliance of Genome Resources, Oct 2024]
    Orthologs
    human mouse all
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    Genomic context

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    See mark3a in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 13 NC_007124.7 (15580750..15668716)
    105 previous assembly GRCz10 (GCF_000002035.5) 13 NC_007124.6 (15449660..15537724)

    Chromosome 13 - NC_007124.7Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108192020 Neighboring gene uncharacterized LOC101882994 Neighboring gene creatine kinase, brain a Neighboring gene tRNA methyltransferase 61A Neighboring gene BCL2 associated athanogene 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. The Hippo pathway effector Wwtr1 regulates cardiac wall maturation in zebrafish. Lai JKH, et al. Development, 2018 May 17. PMID 29773645
    2. In Vivo Visualization of Cardiomyocyte Apicobasal Polarity Reveals Epithelial to Mesenchymal-like Transition during Cardiac Trabeculation. Jiménez-Amilburu V, et al. Cell Rep, 2016 Dec 6. PMID 27926871
    3. Repertoire of protein kinases encoded in the genome of zebrafish shows remarkably large population of PIM kinases. Rakshambikai R, et al. J Bioinform Comput Biol, 2014 Feb. PMID 24467753
    4. Dhx38 is required for the maintenance and differentiation of erythro-myeloid progenitors and hematopoietic stem cells by alternative splicing. Tu J, et al. Development, 2022 Sep 1. PMID 35929537
    5. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC152848

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    MAP/microtubule affinity-regulating kinase 3a
    Names
    MAP/microtubule affinity-regulating kinase 3
    NP_956179.1
    XP_005156682.1
    XP_005156683.1
    XP_005156685.1
    XP_005156686.1
    XP_021336197.1
    XP_021336198.1
    XP_021336199.1
    XP_068081029.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_199885.1 → NP_956179.1  MAP/microtubule affinity-regulating kinase 3a

      See identical proteins and their annotated locations for NP_956179.1

      Status: PROVISIONAL

      Source sequence(s)
      BC047179
      UniProtKB/TrEMBL
      Q802W0
      Related
      ENSDARP00000024907.6, ENSDART00000013525.8
      Conserved Domains (4) summary
      cd12196
      Location:623 → 720
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:57 → 308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14072
      Location:56 → 308
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:326 → 368
      UBA_like_SF; UBA domain-like superfamily

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007124.7 Reference GRCz11 Primary Assembly

      Range
      15580750..15668716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_068224928.1 → XP_068081029.1  MAP/microtubule affinity-regulating kinase 3a isoform X8

    2. XM_005156628.5 → XP_005156685.1  MAP/microtubule affinity-regulating kinase 3a isoform X4

      UniProtKB/TrEMBL
      A0A8M2B2R7
      Conserved Domains (3) summary
      smart00220
      Location:57 → 308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14072
      Location:56 → 308
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:326 → 368
      UBA_like_SF; UBA domain-like superfamily

    3. XM_021480523.2 → XP_021336198.1  MAP/microtubule affinity-regulating kinase 3a isoform X6

      UniProtKB/TrEMBL
      A0A8M9Q9J6
      Conserved Domains (2) summary
      cd14072
      Location:56 → 308
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:326 → 368
      UBA_like_SF; UBA domain-like superfamily

    4. XM_021480522.2 → XP_021336197.1  MAP/microtubule affinity-regulating kinase 3a isoform X1

      UniProtKB/TrEMBL
      A0A8M9PXN3
      Conserved Domains (3) summary
      cd12196
      Location:647 → 744
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      cd14072
      Location:56 → 308
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:326 → 368
      UBA_like_SF; UBA domain-like superfamily

    5. XM_005156626.2 → XP_005156683.1  MAP/microtubule affinity-regulating kinase 3a isoform X3

      UniProtKB/TrEMBL
      A0A2R8QKT7, A0A8M2B2N9
      Related
      ENSDARP00000153634.1, ENSDART00000190067.1
      Conserved Domains (4) summary
      cd12196
      Location:632 → 729
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:57 → 308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14072
      Location:56 → 308
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:326 → 368
      UBA_like_SF; UBA domain-like superfamily

    6. XM_005156629.5 → XP_005156686.1  MAP/microtubule affinity-regulating kinase 3a isoform X5

      UniProtKB/TrEMBL
      A0A8M2B2Y7
      Conserved Domains (3) summary
      smart00220
      Location:57 → 308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14072
      Location:56 → 308
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:326 → 368
      UBA_like_SF; UBA domain-like superfamily

    7. XM_021480524.2 → XP_021336199.1  MAP/microtubule affinity-regulating kinase 3a isoform X7

      UniProtKB/TrEMBL
      A0A8M9QF87
      Conserved Domains (2) summary
      cd14072
      Location:56 → 308
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:326 → 368
      UBA_like_SF; UBA domain-like superfamily

    8. XM_005156625.2 → XP_005156682.1  MAP/microtubule affinity-regulating kinase 3a isoform X2

      UniProtKB/TrEMBL
      A0A8M2B3D6, E9QEM6
      Related
      ENSDARP00000041292.8, ENSDART00000041293.8
      Conserved Domains (4) summary
      cd12196
      Location:638 → 735
      MARK1-3_C; C-terminal, kinase associated domain 1 (KA1), a phospholipid binding domain, of microtubule affinity-regulating kinases 1-3
      smart00220
      Location:57 → 308
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14072
      Location:56 → 308
      STKc_MARK; Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases
      cl21463
      Location:326 → 368
      UBA_like_SF; UBA domain-like superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001077459.1: Suppressed sequence

      Description
      NM_001077459.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript and protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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