ash1l ash1 (absent, small, or homeotic)-like (Drosophila) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ash1lprovided by ZNC
Official Full Name: ash1 (absent, small, or homeotic)-like (Drosophila)provided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-6101
See related: Ensembl:ENSDARG00000070981 AllianceGenome:ZFIN:ZDB-GENE-030131-6101
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fi34d11; wu:fi34d11; si:ch211-81a5.3
Summary: Predicted to enable histone H3K4 methyltransferase activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleus. Predicted to be active in nucleoplasm. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 52. Orthologous to human ASH1L (ASH1 like histone lysine methyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: all
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Genomic context

Location:: chromosome: 19

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	19	NC_007130.7 (9032355..9086941)
105	previous assembly	GRCz10 (GCF_000002035.5)	19	NC_007130.6 (9113411..9168016)

Chromosome 19 - NC_007130.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin binding	IEA Inferred from Electronic Annotation more info
enables histone H3K4 methyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables histone methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in protein-containing complex organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: histone-lysine N-methyltransferase ASH1L

NP_001333336.1

EC 2.1.1.354

XP_005159540.1

EC 2.1.1.354

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001346407.1 → NP_001333336.1 histone-lysine N-methyltransferase ASH1L

Status: VALIDATED

Source sequence(s)

CR626935

UniProtKB/TrEMBL

A0A8M1P9K9, F1QSJ1, F1QY85

Related

ENSDARP00000105655.3, ENSDART00000127755.5

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007130.7 Reference GRCz11 Primary Assembly

Range

9032355..9086941

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005159483.5 → XP_005159540.1 histone-lysine N-methyltransferase ASH1L isoform X1

See identical proteins and their annotated locations for XP_005159540.1

UniProtKB/TrEMBL

A0A0R4J6P5, A0A8M2B6D3

Related

ENSDARP00000052914.6, ENSDART00000052915.8

Conserved Domains (7) summary

cd05525
Location:2408 → 2513

Bromo_ASH1; Bromodomain; ASH1_like sub-family. ASH1 (absent, small, or homeotic 1) is a member of the trithorax-group in Drosophila melanogaster, an epigenetic transcriptional regulator of HOX genes. Drosophila ASH1 has been shown to methylate specific lysines in ...

smart00570
Location:2037 → 2088

AWS; associated with SET domains

smart00317
Location:2091 → 2238

SET; SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain

COG5076
Location:2281 → 2500

COG5076; Transcription factor involved in chromatin remodeling, contains bromodomain [Chromatin structure and dynamics / Transcription]

cd04717
Location:2633 → 2772

BAH_polybromo; BAH, or Bromo Adjacent Homology domain, as present in polybromo and yeast RSC1/2. The human polybromo protein (BAF180) is a component of the SWI/SNF chromatin-remodeling complex PBAF. It is thought that polybromo participates in transcriptional ...

cd15548
Location:2559 → 2601

PHD_ASH1L; PHD finger found in histone-lysine N-methyltransferase ASH1L

pfam09786
Location:529 → 674

CytochromB561_N; Cytochrome B561, N terminal