foxa3 forkhead box A3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: foxa3provided by ZNC
Official Full Name: forkhead box A3provided by ZNC
Primary source: ZFIN:ZDB-GENE-980526-423
See related: Ensembl:ENSDARG00000012788 AllianceGenome:ZFIN:ZDB-GENE-980526-423
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fkd2; Zffkh1; fa11c04; fc37a08; zf-FKH1; forkhead-2; wu:fa11c04; wu:fc37a08
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including axial mesoderm morphogenesis; hatching gland development; and nervous system development. Located in nucleus. Is expressed in several structures, including axial mesoderm; digestive system; endoderm; germ ring; and hatching gland. Orthologous to human FOXA3 (forkhead box A3). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 18

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	18	NC_007129.7 (46350574..46354010, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	18	NC_007129.6 (46352556..46355992, complement)

Chromosome 18 - NC_007129.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

in FoxA2-FoxA3 double morphants, precursors of axial tissues are correctly induced at early gastrula stage, but their dorsal midline identity is not maintained during development
Title: FoxA transcription factors are essential for the development of dorsal axial structures.
FoxA3 and goosecoid cooperate to promote formation of anterior neural tissue by protecting, as early as blastula stage, presumptive anterior neural cells from an irreversible caudalization by the posteriorizing factor Wnt8a.
Title: FoxA3 and goosecoid promote anterior neural fate through inhibition of Wnt8a activity before the onset of gastrulation.

Submit: New GeneRIF Correction

General gene information

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Markers

fa11c04.s1 (e-PCR)
- UniSTS:202298

fkd2 (e-PCR)
- UniSTS:205414

fc37a08.x1 (e-PCR)
- UniSTS:188053

Z10729 (e-PCR)
- UniSTS:204695

fa11c04.r1 (e-PCR)
- UniSTS:186843

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in anatomical structure morphogenesis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within axial mesoderm morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within axial mesoderm morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within floor plate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hatching gland development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural plate anterior/posterior regionalization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: hepatocyte nuclear factor 3-gamma

Names: fork head domain protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131299.1 → NP_571374.1 hepatocyte nuclear factor 3-gamma

See identical proteins and their annotated locations for NP_571374.1

Status: PROVISIONAL

Source sequence(s)

AF052245

UniProtKB/TrEMBL

O73778

Related

ENSDARP00000006410.7, ENSDART00000010813.9

Conserved Domains (3) summary

smart00339
Location:143 → 231

FH; FORKHEAD

pfam08430
Location:17 → 142

Forkhead_N; Forkhead N-terminal region

pfam09354
Location:374 → 408

HNF_C; HNF3 C-terminal domain