mib1 MIB E3 ubiquitin protein ligase 1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mib1provided by ZNC
Official Full Name: MIB E3 ubiquitin protein ligase 1provided by ZNC
Primary source: ZFIN:ZDB-GENE-030404-2
See related: Ensembl:ENSDARG00000102184 AllianceGenome:ZFIN:ZDB-GENE-030404-2
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mib; cg5841; fe47f05; chunp6889; im:7148100; wu:fe47f05
Summary: Enables identical protein binding activity. Contributes to ubiquitin-protein transferase activity. Acts upstream of or within several processes, including nervous system development; sensory system development; and tube morphogenesis. Located in endocytic vesicle and perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in blood vessel; nervous system; neural tube; and pectoral fin. Used to study epilepsy. Human ortholog(s) of this gene implicated in left ventricular noncompaction. Orthologous to human MIB1 (MIB E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	2	NC_007113.7 (4074193..4161258)
105	previous assembly	GRCz10 (GCF_000002035.5)	2	NC_007113.6 (4233222..4320325)

Chromosome 2 - NC_007113.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data reported the first genome-wide analysis and transcriptome profiling of the new mib(nn2002) in Zebrafish. These results suggested that the defects in the somitogenesis were related to the down-regulated segmentation genes, such as foxc1a, smyhc1, myod1 and mylpfa.
Title: Comparative transcriptomic characterization of a new mib mutant allele, mib(nn2002), in zebrafish.
Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.
Title: Epb41l5 competes with Delta as a substrate for Mib1 to coordinate specification and differentiation of neurons.
indicate that miR-10 regulates the angiogenic behaviour in a Notch-dependent manner by directly targeting mib1
Title: MicroRNA-10a/10b represses a novel target gene mib1 to regulate angiogenesis.
forms of DeltaD that have the MID can activate Notch in trans and suppress early neurogenesis when mRNA encoding it is ectopically expressed in zebrafish embryos.
Title: Identification of the Mind Bomb1 Interaction Domain in Zebrafish DeltaD.
Mib and Mib2 interact with Fih-1 that is involved in the hypoxia signaling pathway.
Title: New classes of mind bomb-interacting proteins identified from yeast two-hybrid screens.
Data indicate a general down-regulation of Notch signaling genes necessary for proper brain development in mind bomb-mutant zebrafish embryos.
Title: Aberrant expression of genes necessary for neuronal development and Notch signaling in an epileptic mind bomb zebrafish.
mind bomb mutants have downregulation of several genes necessary for GABA-mediated signaling. Spontaneous seizures are seen in these animals.
Title: Spontaneous seizures and altered gene expression in GABA signaling pathways in a mind bomb mutant zebrafish.
Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions
Title: Mib-Jag1-Notch signalling regulates patterning and structural roles of the notochord by controlling cell-fate decisions.
The mib ( ta52b ) mutation may affect not only neurogenesis but also mesoderm development. These results provide new insights into Notch signaling pathway.
Title: Transcriptome analysis of the zebrafish mind bomb mutant.
Mib encodes a RING ubiquitin ligase that promotes ubiquitylation and internalization of Delta.
Title: Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

fe47f05.x1 (e-PCR)
- UniSTS:204382

fd17c12.y1 (e-PCR)
- UniSTS:195220

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info
contributes_to ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
enables ubiquitin-protein transferase activity	IEA Inferred from Electronic Annotation more info
contributes_to ubiquitin-protein transferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Notch signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within Notch signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within anterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within blood vessel development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within blood vessel morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within central nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within definitive hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right symmetry	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within developmental pigmentation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within diencephalon development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within digestive tract morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic pattern specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within endothelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within floor plate formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within formation of anatomical boundary	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within generation of neurons	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within habenula development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hair cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic progenitor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hemopoiesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within hindbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inner ear receptor cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within lateral line nerve development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neural retina development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neurogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate commitment	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within neuron fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord cell development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within notochord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within optic cup formation involved in camera-type eye development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within otic vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pigment cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of protein ubiquitination	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within posterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within posterior lateral line neuromast primordium migration	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pronephric duct development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pronephros development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein autoubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein autoubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein ubiquitination	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of Notch signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of glial cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of neuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of receptor internalization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of receptor-mediated endocytosis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere boundary formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within rhombomere development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somitogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord association neuron specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within spinal cord motor neuron cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sprouting angiogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within taste bud formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within trigeminal ganglion development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ubiquitin-dependent endocytosis	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within vasculogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within ventral spinal cord interneuron specification	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in endocytic vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IGI Inferred from Genetic Interaction more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein-containing complex	IPI Inferred from Physical Interaction more info	PubMed
part_of ubiquitin ligase complex	IC Inferred by Curator more info	PubMed

General protein information

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Preferred Names: E3 ubiquitin-protein ligase mib1

Names: RING-type E3 ubiquitin transferase mib1; mind bomb; mindbomb E3 ubiquitin protein ligase 1; protein mind bomb; white tail; wit

NP_775393.2

EC 2.3.2.27

XP_009295119.1

EC 2.3.2.27

XP_009295120.1

EC 2.3.2.27

XP_009295121.1

EC 2.3.2.27

XP_009295123.1

EC 2.3.2.27

XP_009295129.1

EC 2.3.2.27

XP_009295134.1

EC 2.3.2.27

XP_068079318.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173286.3 → NP_775393.2 E3 ubiquitin-protein ligase mib1

See identical proteins and their annotated locations for NP_775393.2

Status: PROVISIONAL

Source sequence(s)

AF537301

UniProtKB/Swiss-Prot

Q804S5, Q8JHG3

Related

ENSDARP00000139883.3, ENSDART00000165634.3

Conserved Domains (7) summary

smart00248
Location:464 → 492

ANK; ankyrin repeats

cd00204
Location:524 → 652

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd02339
Location:83 → 127

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

pfam06701
Location:154 → 218

MIB_HERC2; Mib_herc2

pfam12796
Location:600 → 696

Ank_2; Ankyrin repeats (3 copies)

pfam13920
Location:860 → 905

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

sd00045
Location:464 → 527

ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007113.7 Reference GRCz11 Primary Assembly

Range

4074193..4161258

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009296854.4 → XP_009295129.1 E3 ubiquitin-protein ligase mib1 isoform X6

UniProtKB/TrEMBL

A0A8M3AVC7

Conserved Domains (7) summary

smart00248
Location:464 → 492

ANK; ankyrin repeats

cd00204
Location:524 → 652

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd02339
Location:83 → 127

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

pfam06701
Location:154 → 218

MIB_HERC2; Mib_herc2

pfam12796
Location:600 → 696

Ank_2; Ankyrin repeats (3 copies)

pfam13920
Location:860 → 905

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

sd00045
Location:464 → 527

ANK; ANK repeat [structural motif]
XM_009296844.4 → XP_009295119.1 E3 ubiquitin-protein ligase mib1 isoform X1

UniProtKB/TrEMBL

A0A8M3B640, H9GYU5

Related

ENSDARP00000132570.2, ENSDART00000163507.3

Conserved Domains (7) summary

smart00248
Location:475 → 503

ANK; ankyrin repeats

cd00204
Location:535 → 663

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd02339
Location:83 → 127

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

pfam06701
Location:154 → 218

MIB_HERC2; Mib_herc2

pfam12796
Location:611 → 707

Ank_2; Ankyrin repeats (3 copies)

pfam13920
Location:871 → 916

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

sd00045
Location:475 → 538

ANK; ANK repeat [structural motif]
XM_009296845.4 → XP_009295120.1 E3 ubiquitin-protein ligase mib1 isoform X2

UniProtKB/TrEMBL

A0A8M3ANM1

Conserved Domains (7) summary

smart00248
Location:475 → 503

ANK; ankyrin repeats

cd00204
Location:535 → 663

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd02339
Location:83 → 127

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

pfam06701
Location:154 → 218

MIB_HERC2; Mib_herc2

pfam12796
Location:611 → 707

Ank_2; Ankyrin repeats (3 copies)

pfam13920
Location:871 → 916

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

sd00045
Location:475 → 538

ANK; ANK repeat [structural motif]
XM_009296848.4 → XP_009295123.1 E3 ubiquitin-protein ligase mib1 isoform X5

UniProtKB/TrEMBL

A0A8M3AMW2

Conserved Domains (7) summary

smart00248
Location:475 → 503

ANK; ankyrin repeats

cd00204
Location:535 → 663

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd02339
Location:83 → 127

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

pfam06701
Location:154 → 218

MIB_HERC2; Mib_herc2

pfam12796
Location:611 → 707

Ank_2; Ankyrin repeats (3 copies)

pfam13920
Location:871 → 916

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

sd00045
Location:475 → 538

ANK; ANK repeat [structural motif]
XM_009296846.4 → XP_009295121.1 E3 ubiquitin-protein ligase mib1 isoform X3

UniProtKB/TrEMBL

A0A8M3AYD8

Conserved Domains (7) summary

smart00248
Location:475 → 503

ANK; ankyrin repeats

cd00204
Location:535 → 663

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd02339
Location:83 → 127

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

pfam06701
Location:154 → 218

MIB_HERC2; Mib_herc2

pfam12796
Location:611 → 707

Ank_2; Ankyrin repeats (3 copies)

pfam13920
Location:871 → 916

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

sd00045
Location:475 → 538

ANK; ANK repeat [structural motif]
XM_068223217.1 → XP_068079318.1 E3 ubiquitin-protein ligase mib1 isoform X4
XM_009296859.4 → XP_009295134.1 E3 ubiquitin-protein ligase mib1 isoform X7

UniProtKB/TrEMBL

A0A8M3AMW8

Conserved Domains (7) summary

smart00248
Location:475 → 503

ANK; ankyrin repeats

cd00204
Location:535 → 663

ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...

cd02339
Location:83 → 127

ZZ_Mind_bomb; Zinc finger, ZZ type. Zinc finger present in Drosophila Mind bomb (D-mib) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding. Mind bomb is an E3 ubiqitin ligase that has ...

pfam06701
Location:154 → 218

MIB_HERC2; Mib_herc2

pfam12796
Location:611 → 707

Ank_2; Ankyrin repeats (3 copies)

pfam13920
Location:871 → 916

zf-C3HC4_3; Zinc finger, C3HC4 type (RING finger)

sd00045
Location:475 → 538

ANK; ANK repeat [structural motif]