RNF166 ring finger protein 166 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RNF166provided by HGNC
Official Full Name: ring finger protein 166provided by HGNC
Primary source: HGNC:HGNC:28856
See related: Ensembl:ENSG00000158717 MIM:617178; AllianceGenome:HGNC:28856
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary: Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein polyubiquitination and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in bone marrow (RPKM 13.1), spleen (RPKM 9.1) and 23 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q24.2-q24.3

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (88696501..88706408, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (94765637..94775565, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (88762909..88772816, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins.
Title: RNF166 promotes colorectal cancer progression by recognizing and destabilizing poly-ADP-ribosylated angiomotins.
RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins.
Title: RNF166 plays a dual role for Lys63-linked ubiquitination and sumoylation of its target proteins.
Podocyte RNF166 deficiency alleviates diabetic nephropathy by mitigating mitochondria impairment and apoptosis via regulation of CYLD signal.
Title: Podocyte RNF166 deficiency alleviates diabetic nephropathy by mitigating mitochondria impairment and apoptosis via regulation of CYLD signal.
An unbiased informatics approach pinpointed RNF166 as a key gene that interacts with the autophagy network and controls the recruitment of ubiquitin as well as the autophagy adaptors p62 and NDP52 to bacteria.
Title: RNF166 Determines Recruitment of Adaptor Proteins during Antibacterial Autophagy.
These findings suggest that RNF166 positively regulates RNA virus-triggered IFN-beta production by enhancing the ubiquitination of TRAF3 and TRAF6.
Title: Ring finger protein 166 potentiates RNA virus-induced interferon-β production via enhancing the ubiquitination of TRAF3 and TRAF6.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A Genome-wide Association Study of Autism Using the Simons Simplex Collection: Does Reducing Phenotypic Heterogeneity in Autism Increase Genetic Homogeneity? EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin protein ligase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in autophagy	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in protein polyubiquitination	IBA Inferred from Biological aspect of Ancestor more info
involved_in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: E3 ubiquitin-protein ligase RNF166

Names: RING-type E3 ubiquitin transferase RNF166

NP_001165286.1

EC 2.3.2.27

NP_001165287.1

EC 2.3.2.27

NP_849163.1

EC 2.3.2.27

XP_011521147.1

EC 2.3.2.27

XP_011521149.1

EC 2.3.2.27

XP_016878401.1

EC 2.3.2.27

XP_047289533.1

EC 2.3.2.27

XP_047289534.1

EC 2.3.2.27

XP_047289535.1

EC 2.3.2.27

XP_047289536.1

EC 2.3.2.27

XP_054235492.1

EC 2.3.2.27

XP_054235493.1

EC 2.3.2.27

XP_054235494.1

EC 2.3.2.27

XP_054235495.1

EC 2.3.2.27

XP_054235496.1

EC 2.3.2.27

XP_054235497.1

EC 2.3.2.27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001171815.2 → NP_001165286.1 E3 ubiquitin-protein ligase RNF166 isoform 2

See identical proteins and their annotated locations for NP_001165286.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an in-frame segment of the 5' coding region, compared to variant 1, resulting in an isoform (2) that is shorter than isoform 1.

Source sequence(s)

AC138028

Consensus CDS

CCDS54057.1

UniProtKB/Swiss-Prot

Q96A37

Related

ENSP00000457336.1, ENST00000567844.1

Conserved Domains (1) summary

pfam05605
Location:68 → 127

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
NM_001171816.2 → NP_001165287.1 E3 ubiquitin-protein ligase RNF166 isoform 3

See identical proteins and their annotated locations for NP_001165287.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.

Source sequence(s)

AC138028

Consensus CDS

CCDS54056.1

UniProtKB/Swiss-Prot

Q96A37

Related

ENSP00000440454.2, ENST00000541206.6

Conserved Domains (1) summary

pfam05605
Location:40 → 99

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
NM_178841.4 → NP_849163.1 E3 ubiquitin-protein ligase RNF166 isoform 1

See identical proteins and their annotated locations for NP_849163.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longest isoform (1).

Source sequence(s)

AC138028

Consensus CDS

CCDS10969.1

UniProtKB/Swiss-Prot

B3KQ03, D3DX75, H3BTU8, Q96A37, Q96DM0

UniProtKB/TrEMBL

A8K4F5

Related

ENSP00000326095.4, ENST00000312838.9

Conserved Domains (3) summary

cd16549
Location:30 → 76

RING-HC_RNF166; RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins

pfam05605
Location:149 → 208

zf-Di19; Drought induced 19 protein (Di19), zinc-binding

pfam18574
Location:92 → 124

zf_C2HC_14; C2HC Zing finger domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000016.10 Reference GRCh38.p14 Primary Assembly

Range

88696501..88706408 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047433578.1 → XP_047289534.1 E3 ubiquitin-protein ligase RNF166 isoform X3
XM_011522845.3 → XP_011521147.1 E3 ubiquitin-protein ligase RNF166 isoform X1

Conserved Domains (2) summary

TIGR01628
Location:178 → 304

PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family

cd16549
Location:30 → 76

RING-HC_RNF166; RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins
XM_047433580.1 → XP_047289536.1 E3 ubiquitin-protein ligase RNF166 isoform X6

Related

ENSP00000446301.2, ENST00000537718.6
XM_047433577.1 → XP_047289533.1 E3 ubiquitin-protein ligase RNF166 isoform X2
XM_011522847.2 → XP_011521149.1 E3 ubiquitin-protein ligase RNF166 isoform X5

Conserved Domains (1) summary

pfam05605
Location:40 → 99

zf-Di19; Drought induced 19 protein (Di19), zinc-binding
XM_047433579.1 → XP_047289535.1 E3 ubiquitin-protein ligase RNF166 isoform X5
XM_017022912.2 → XP_016878401.1 E3 ubiquitin-protein ligase RNF166 isoform X4

Conserved Domains (2) summary

PLN03208
Location:24 → 131

PLN03208; E3 ubiquitin-protein ligase RMA2; Provisional

cd16549
Location:30 → 76

RING-HC_RNF166; RING finger, HC subclass, found in RING finger protein 166 (RNF166) and similar proteins