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    CDC42BPB CDC42 binding protein kinase beta [ Cercocebus atys (sooty mangabey) ]

    Gene ID: 105596734, updated on 13-Mar-2024

    Summary

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    Gene symbol
    CDC42BPB
    Gene description
    CDC42 binding protein kinase beta
    See related
    Ensembl:ENSCATG00000017326
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Cercocebus atys
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Cercocebus
    Orthologs
    human mouse all
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    Genomic context

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    See CDC42BPB in Genome Data Viewer
    Location:
    chromosome: Un
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    100 current Caty_1.0 (GCF_000955945.1) Unplaced Scaffold NW_012001960.1 (21653405..21798747, complement)

    NW_012001960.1Genomic Context describing neighboring genes Neighboring gene REST corepressor 1 Neighboring gene 60S ribosomal protein L23a pseudogene Neighboring gene TNF receptor associated factor 3 Neighboring gene amnion associated transmembrane protein Neighboring gene 60S ribosomal protein L13 pseudogene Neighboring gene exocyst complex component 3 like 4 Neighboring gene TNF alpha induced protein 2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NW_012001960.1 Unplaced Scaffold Reference Caty_1.0

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actomyosin structure organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in peptidyl-threonine phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actomyosin IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase MRCK beta

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Cercocebus atys Annotation Release 100 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Caty_1.0

    Genomic

    1. NW_012001960.1 Reference Caty_1.0

      Range
      21653405..21798747 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_012084057.1 → XP_011939447.1  serine/threonine-protein kinase MRCK beta isoform X2

      UniProtKB/TrEMBL
      A0A2K5KX99
      Related
      ENSCATP00000005344.1, ENSCATT00000020172.1
      Conserved Domains (8) summary
      pfam08826
      Location:878 → 939
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:76 → 342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:1026 → 1075
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1085 → 1219
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1245 → 1510
      CNH; CNH domain
      pfam13868
      Location:426 → 786
      TPH; Trichohyalin-plectin-homology domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    2. XM_012084058.1 → XP_011939448.1  serine/threonine-protein kinase MRCK beta isoform X3

      Conserved Domains (8) summary
      pfam08826
      Location:878 → 939
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:76 → 342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:1000 → 1049
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1059 → 1193
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1219 → 1484
      CNH; CNH domain
      pfam13868
      Location:426 → 786
      TPH; Trichohyalin-plectin-homology domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    3. XM_012084056.1 → XP_011939446.1  serine/threonine-protein kinase MRCK beta isoform X1

      Conserved Domains (8) summary
      pfam08826
      Location:878 → 939
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:76 → 342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd00029
      Location:1026 → 1075
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1085 → 1219
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1245 → 1510
      CNH; CNH domain
      pfam13868
      Location:426 → 786
      TPH; Trichohyalin-plectin-homology domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    4. XM_012084060.1 → XP_011939450.1  serine/threonine-protein kinase MRCK beta isoform X5

      Conserved Domains (9) summary
      pfam08826
      Location:628 → 689
      DMPK_coil; DMPK coiled coil domain like
      smart00285
      Location:1333 → 1360
      PBD; P21-Rho-binding domain
      COG1340
      Location:185 → 459
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:776 → 825
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:835 → 969
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      pfam00780
      Location:995 → 1260
      CNH; CNH domain
      pfam15796
      Location:278 → 356
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl02488
      Location:198 → 414
      SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
      cl21453
      Location:1 → 161
      PKc_like; Protein Kinases, catalytic domain

    5. XM_012084061.1 → XP_011939451.1  serine/threonine-protein kinase MRCK beta isoform X6

      Conserved Domains (8) summary
      pfam08826
      Location:878 → 934
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:76 → 342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:435 → 709
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:1026 → 1075
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1085 → 1219
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase
      cl02434
      Location:1245 → 1402
      CNH; CNH domain

    6. XM_012084059.1 → XP_011939449.1  serine/threonine-protein kinase MRCK beta isoform X4

      Conserved Domains (8) summary
      pfam08826
      Location:878 → 934
      DMPK_coil; DMPK coiled coil domain like
      smart00220
      Location:76 → 342
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      COG1340
      Location:435 → 709
      COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
      cd00029
      Location:1026 → 1075
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd01243
      Location:1085 → 1219
      PH_MRCK; MRCK (myotonic dystrophy-related Cdc42-binding kinase) pleckstrin homology (PH) domain
      cd05624
      Location:3 → 411
      STKc_MRCK_beta; Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta
      pfam00780
      Location:1245 → 1469
      CNH; CNH domain
      pfam15796
      Location:528 → 606
      KELK; KELK-motif containing domain of MRCK Ser/Thr protein kinase

    RNA

    1. XR_001018848.1 RNA Sequence

    2. XR_001018847.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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