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    lxn latexin [ Danio rerio (zebrafish) ]

    Gene ID: 494053, updated on 18-Sep-2024

    Summary

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    Official Symbol
    lxnprovided by ZNC
    Official Full Name
    latexinprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041212-18
    See related
    Ensembl:ENSDARG00000043102 AllianceGenome:ZFIN:ZDB-GENE-041212-18
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    RARRES1; wu:fk66c02; zgc:103612
    Summary
    Predicted to enable metalloendopeptidase inhibitor activity. Predicted to be active in extracellular space. Orthologous to several human genes including LXN (latexin). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See lxn in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (1181425..1199336, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (1220622..1238189, complement)

    Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene purinergic receptor P2Y13 Neighboring gene myeloid leukemia factor 1 Neighboring gene G elongation factor, mitochondrial 1 Neighboring gene major facilitator superfamily domain containing 1 Neighboring gene karyopherin alpha 4 (importin alpha 3) Neighboring gene schwannomin interacting protein 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle. Sahab ZJ, et al. Cancer Res, 2011 Feb 15. PMID 21303978, Free PMC Article
    2. Tumor suppressor RARRES1 links tubulin deglutamylation to mitochondrial metabolism and cell survival. Maimouni S, et al. Oncotarget, 2019 Feb 26. PMID 30899431, Free PMC Article
    3. Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. Cao J, et al. Development, 2016 Jan 15. PMID 26657776, Free PMC Article
    4. IGFBP1 increases β-cell regeneration by promoting α- to β-cell transdifferentiation. Lu J, et al. EMBO J, 2016 Sep 15. PMID 27516442, Free PMC Article
    5. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables metalloendopeptidase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables peptidase inhibitor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within negative regulation of peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    latexin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008596.1 → NP_001008596.1  latexin precursor

      See identical proteins and their annotated locations for NP_001008596.1

      Status: PROVISIONAL

      Source sequence(s)
      BC086837
      UniProtKB/TrEMBL
      Q5PR40
      Related
      ENSDARP00000143725.1, ENSDART00000177869.2
      Conserved Domains (1) summary
      pfam06907
      Location:46 → 259
      Latexin; Latexin

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007126.7 Reference GRCz11 Primary Assembly

      Range
      1181425..1199336 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005169638.4 → XP_005169695.1  latexin isoform X4

      UniProtKB/TrEMBL
      A0A8M2BGX5, F1RDP7
      Conserved Domains (1) summary
      pfam06907
      Location:8 → 220
      Latexin; Latexin

    2. XM_021481397.2 → XP_021337072.1  latexin isoform X2

      UniProtKB/TrEMBL
      A0A8M9Q0C1
      Conserved Domains (1) summary
      pfam06907
      Location:46 → 257
      Latexin

    3. XM_005169637.4 → XP_005169694.1  latexin isoform X1

      UniProtKB/TrEMBL
      A0A286Y993, A0A8M2BGW6
      Conserved Domains (1) summary
      pfam06907
      Location:46 → 258
      Latexin; Latexin

    4. XM_068213540.1 → XP_068069641.1  latexin isoform X1

    5. XM_068213539.1 → XP_068069640.1  latexin isoform X1

    6. XM_021481398.2 → XP_021337073.1  latexin isoform X4

      UniProtKB/TrEMBL
      A0A8M2BGX5, F1RDP7
      Related
      ENSDARP00000063284.5, ENSDART00000063285.6
      Conserved Domains (1) summary
      pfam06907
      Location:8 → 220
      Latexin; Latexin

    7. XM_009291320.4 → XP_009289595.1  latexin isoform X3

      UniProtKB/TrEMBL
      A0A8M3ASB5
      Conserved Domains (1) summary
      pfam06907
      Location:19 → 231
      Latexin; Latexin
    Nucleotide Protein Strain
    Heading Accession and Version

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