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    ZNF708 zinc finger protein 708 [ Homo sapiens (human) ]

    Gene ID: 7562, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ZNF708provided by HGNC
    Official Full Name
    zinc finger protein 708provided by HGNC
    Primary source
    HGNC:HGNC:12945
    See related
    Ensembl:ENSG00000182141 AllianceGenome:HGNC:12945
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KOX8; ZNF15; ZNF15L1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in membrane and nucleus. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in brain (RPKM 4.2), ovary (RPKM 3.4) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZNF708 in Genome Data Viewer
    Location:
    19p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (21291160..21329410, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (21429845..21468128, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (21473962..21512212, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein L36a pseudogene 51 Neighboring gene MPRA-validated peak3409 silencer Neighboring gene COX16 pseudogene 1 Neighboring gene vomeronasal 1 receptor 83 pseudogene Neighboring gene NANOG hESC enhancer GRCh37_chr19:21500539-21501043 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:21510155-21510676 Neighboring gene BCL2 interacting protein 3 pseudogene 25 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14383 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21512069-21513057 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:21540515-21541072 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14385 Neighboring gene zinc finger protein 738 Neighboring gene iron-sulfur cluster assembly 1 pseudogene 7 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:21579974-21580212 Neighboring gene zinc finger protein 493

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Conserved KRAB protein domain identified upstream from the zinc finger region of Kox 8. Thiesen HJ, et al. Nucleic Acids Res, 1991 Jul 25. PMID 1861988, Free PMC Article
    2. Chromosomal localization of two KOX zinc finger genes on chromosome bands 7q21-q22. Rousseau-Merck MF, et al. Ann Genet, 1995. PMID 7486829
    3. Twenty-seven nonoverlapping zinc finger cDNAs from human T cells map to nine different chromosomes with apparent clustering. Huebner K, et al. Am J Hum Genet, 1991 Apr. PMID 2014798, Free PMC Article
    4. Multiple genes encoding zinc finger domains are expressed in human T cells. Thiesen HJ. New Biol, 1990 Apr. PMID 2288909
    5. Acetylation-Mimic Mutation of TRIM28-Lys304 to Gln Attenuates the Interaction with KRAB-Zinc-Finger Proteins and Affects Gene Expression in Leukemic K562 Cells. Chang YJ, et al. Int J Mol Sci, 2023 Jun 6. PMID 37372979, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16755, FLJ46310, DKFZp686L10267

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 708
    Names
    ZNF15, ZNF15L1
    zinc finger protein 15-like 1 (KOX 8)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001297560.2 → NP_001284489.1  zinc finger protein 708 isoform 2

      See identical proteins and their annotated locations for NP_001284489.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC022432, AK311130, BX103920, BX647526, CD704852, DB216212
      UniProtKB/Swiss-Prot
      P17019
      Conserved Domains (3) summary
      COG5048
      Location:78 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:190 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:258 → 282
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001297561.2 → NP_001284490.1  zinc finger protein 708 isoform 2

      See identical proteins and their annotated locations for NP_001284490.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. Variants 2 and 3 encode the same isoform (2), which has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC022432, AK311130, BX103920, BX647526, CD704852
      UniProtKB/Swiss-Prot
      P17019
      Related
      ENSP00000469961.2, ENST00000601295.2
      Conserved Domains (3) summary
      COG5048
      Location:78 → 488
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:190 → 210
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:258 → 282
      zf-H2C2_2; Zinc-finger double domain

    3. NM_021269.3 → NP_067092.2  zinc finger protein 708 isoform 1

      See identical proteins and their annotated locations for NP_067092.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC022432
      Consensus CDS
      CCDS32980.1
      UniProtKB/Swiss-Prot
      P17019, Q6ZMR0
      Related
      ENSP00000349401.2, ENST00000356929.3
      Conserved Domains (5) summary
      smart00349
      Location:4 → 64
      KRAB; krueppel associated box
      COG5048
      Location:142 → 552
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:254 → 274
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 43
      KRAB; KRAB box
      pfam13465
      Location:322 → 346
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      21291160..21329410 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017027203.3 → XP_016882692.1  zinc finger protein 708 isoform X2

    2. XM_047439310.1 → XP_047295266.1  zinc finger protein 708 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      21429845..21468128 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321946.1 → XP_054177921.1  zinc finger protein 708 isoform X2

    2. XM_054321945.1 → XP_054177920.1  zinc finger protein 708 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P17019.6 GenPept UniProtKB/Swiss-Prot:P17019

    Gene LinkOut

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