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    EBI3 Epstein-Barr virus induced 3 [ Homo sapiens (human) ]

    Gene ID: 10148, updated on 12-Nov-2024

    GeneRIFs: Gene References Into Functions

    GeneRIFPubMed TitleDate
    Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy Complications.

    Emerging Roles of IL-27 in Trophoblast Cells and Pregnancy Complications.
    Luo YH, Zhang YY, Li MQ, Zhang XY, Zheng ZM.

    10/29/2024
    Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma.

    Tumor-derived interleukin 35 mediates the dissemination of gemcitabine resistance in pancreatic adenocarcinoma.
    Sun H, Ge Y, Liu J, Li Z, Li H, Zhao T, Wang X, Feng Y, Wang H, Gao S, Shi L, Yang S, Sun P, Chang A, Hao J, Huang C.

    08/7/2024
    Human interleukin-12alpha and EBI3 are cytokines with anti-inflammatory functions.

    Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.
    Hildenbrand K, Bohnacker S, Menon PR, Kerle A, Prodjinotho UF, Hartung F, Strasser PC, Catici DAM, Rührnößl F, Haslbeck M, Schumann K, Müller SI, da Costa CP, Esser-von Bieren J, Feige MJ., Free PMC Article

    11/1/2023
    Epstein-Barr virus-induced gene 3 commits human mesenchymal stem cells to differentiate into chondrocytes via endoplasmic reticulum stress sensor.

    Epstein-Barr virus-induced gene 3 commits human mesenchymal stem cells to differentiate into chondrocytes via endoplasmic reticulum stress sensor.
    Zhang T, Yamagata K, Iwata S, Sonomoto K, Trimova G, Nguyen AP, Hao H, Shan Y, Nguyen MP, Nakayamada S, Tanaka Y., Free PMC Article

    01/14/2023
    [Expression of Tregs and IL-35 in Peripheral Blood of Patients with Newly Diagnosed Acute Myeloid Leukemia].

    [Expression of Tregs and IL-35 in Peripheral Blood of Patients with Newly Diagnosed Acute Myeloid Leukemia].
    Yang PX, Wang P, Fang L, Wang Q.

    12/17/2022
    A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under Inflammatory Conditions.

    A Chaperone-Like Role for EBI3 in Collaboration With Calnexin Under Inflammatory Conditions.
    Watanabe A, Mizoguchi I, Hasegawa H, Katahira Y, Inoue S, Sakamoto E, Furusaka Y, Sekine A, Miyakawa S, Murakami F, Xu M, Yoneto T, Yoshimoto T., Free PMC Article

    03/19/2022
    Epstein-Barr Virus-induced Gene 3 as a Novel Biomarker in Metastatic Melanoma With Infiltrating CD8(+) T Cells: A Study Based on The Cancer Genome Atlas (TCGA).

    Epstein-Barr Virus-induced Gene 3 as a Novel Biomarker in Metastatic Melanoma With Infiltrating CD8(+) T Cells: A Study Based on The Cancer Genome Atlas (TCGA).
    Yonekura S.

    01/15/2022
    Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes.

    Multifaceted Analysis of IL-23A- and/or EBI3-Including Cytokines Produced by Psoriatic Keratinocytes.
    Tachibana K, Tang N, Urakami H, Kajita A, Kobashi M, Nomura H, Sasakura M, Sugihara S, Jiang F, Tomonobu N, Sakaguchi M, Ouchida M, Morizane S., Free PMC Article

    12/25/2021
    Epstein-Barr virus-induced gene 3 (EBI3) single nucleotide polymorphisms and their association with central obesity and risk factors for cardiovascular disease: The GEA study.

    Epstein-Barr virus-induced gene 3 (EBI3) single nucleotide polymorphisms and their association with central obesity and risk factors for cardiovascular disease: The GEA study.
    Posadas-Sánchez R, Del Carmen González-Salazar M, Cardoso-Saldaña G, Andrés Criales-Vera S, Reyes-Barrera J, Pérez-Hernández N, Manuel Fragoso J, Vargas-Alarcón G.

    12/11/2021
    Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis.

    Epigenetic DNA Methylation of EBI3 Modulates Human Interleukin-35 Formation via NFkB Signaling: A Promising Therapeutic Option in Ulcerative Colitis.
    Wetzel A, Scholtka B, Schumacher F, Rawel H, Geisendörfer B, Kleuser B., Free PMC Article

    07/3/2021
    Analysis for interaction between interleukin-35 genes polymorphisms and risk factors on susceptibility to coronary heart disease in the Chinese Han population.

    Analysis for interaction between interleukin-35 genes polymorphisms and risk factors on susceptibility to coronary heart disease in the Chinese Han population.
    Li H, Liu YX, Huang JY, Zhu YF, Wang K., Free PMC Article

    06/19/2021
    Reduced IL-35 in patients with immune thrombocytopenia.

    Reduced IL-35 in patients with immune thrombocytopenia.
    Sun RJ, Yuan D, Liu SY, Zhu JJ, Shan NN.

    05/22/2021
    Lack of evidence for expression and function of IL-39 in human immune cells.

    Lack of evidence for expression and function of IL-39 in human immune cells.
    Ecoeur F, Weiss J, Schleeger S, Guntermann C., Free PMC Article

    01/16/2021
    Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.

    Epigenetic histone modulation contributes to improvements in inflammatory bowel disease via EBI3.
    Wetzel A, Scholtka B, Gerecke C, Kleuser B., Free PMC Article

    11/28/2020
    IL-35 in inducing the activation of an anti-inflammatory M2-like macrophage phenotype, promoting early stent endothelialization after stent implantation.

    Interleukin-35 promotes early endothelialization after stent implantation by regulating macrophage activation.
    Liu X, Zhang R, Hou J, Wu J, Zhang M, Fang S, Wang X, Huang X, Tian J, Li H, Sun Y, Yu B.

    02/1/2020
    The polymorphism of rs4740 of IL-35 encoding gene is associated with the occurrence of renal disorder and hematological disorder of SLE patients.

    Association between Interleukin 35 Gene Single Nucleotide Polymorphisms and Systemic Lupus Erythematosus in a Chinese Han Population.
    Guan SY, Liu LN, Mao YM, Zhao CN, Wu Q, Dan YL, Bellua Sam N, Pan HF., Free PMC Article

    01/11/2020
    this review describes the role of IL-35 in immune-related diseases

    Interleukin-35 in immune-related diseases: protection or destruction.
    Zhang J, Zhang Y, Wang Q, Li C, Deng H, Si C, Xiong H., Free PMC Article

    11/2/2019
    Analysis for EBI3 (rs4740) genotyping showed a significant association of "GG" genotypie with reduced risk for disease.

    Genetic polymorphism in association with susceptibility to tuberculosis: a study in a Pakistani population.
    Naz A, Aslam MA, Khan AUH, Rasul S, Manzoor H, Iqbal R, Shehzad A, Ali M., Free PMC Article

    10/12/2019
    Data suggest that reduced mRNA expression of forkhead box P3 (FoxP3) and circulating level of IL-35 (a heterodimer of EBI3 and IL12A ) are of significance in the context of coronary artery disease (CAD) pathogenesis.

    Circulating Levels of IL-35 and Gene Expression of FoxP3 in Coronary Artery Disease: Is There Any Interplay Between Them and 25-Hydroxyvitamin D3?
    Shateri H, Fadaei R, Najafi M, Vatannejad A, Teimouri M, Zali F, Emamgholipour S, Parvaz E, Asadnia M, Doosti M.

    09/21/2019
    Regarding the significant negative correlation between EBI-3 gene expression and plasma levels of neopterin, it can be concluded that the altered gene expression of EBI-3 may play a role in the pathogenesis of rheumatoid arthritis.

    Decreased Gene Expression of Epstein-Barr Virus-Induced Gene 3 (EBI-3) may Contribute to the Pathogenesis of Rheumatoid Arthritis.
    Iranshahi N, Assar S, Amiri SM, Zafari P, Fekri A, Taghadosi M.

    08/24/2019
    CC genotype of rs428253 in EBI3 was related to an increased risk of coronary heart disease in the Chinese Zhuang population.

    Association between interleukin-35 polymorphisms and coronary heart disease in the Chinese Zhuang population: a case-control study.
    Lin Y, Xue Y, Huang X, Lu J, Yang Z, Ye J, Zhang S, Liu L, Liu Y, Shi Y.

    08/10/2019
    IL-35 may have the effect on inhibiting inflammatory process in Kawasaki disease and further preventing Kawasaki disease patients from coronary artery lesion.

    Association between IL-35 and coronary arterial lesions in children with Kawasaki disease.
    Su Y, Feng S, Luo L, Liu R, Yi Q.

    06/1/2019
    Researchers have constructed IL-35 gene-modified mesenchymal stem cells (MSCs)and explored their functions and mechanisms in some disease models. In this review, we discuss the potential tolerance-inducing effects of MSCs in transplantation and briefly introduce the immunoregulatory functions of the IL-35 gene-modified MSCs.

    Mesenchymal stem cells overexpressing IL-35: a novel immunosuppressive strategy and therapeutic target for inducing transplant tolerance.
    Guo H, Li B, Wang W, Zhao N, Gao H., Free PMC Article

    04/3/2019
    IL-35 may be involved in the inflammatory process of sarcoidosis and play an important role in the pathogenesis of the disease.

    [The plasma level and gene expression in peripheral blood of interleukin-35 in patients with sarcoidosis and its clinical significance].
    Song XY, Huang H, Liu YZ, Li S, Zhao YY, Xu ZJ.

    02/9/2019
    Tumor associated macrophages secrete interleukin-35 (IL-35) to facilitate metastatic colonization through activation of JAK2-STAT6-GATA3 signaling to reverse epithelial-mesenchymal transition (EMT) in cancer cells.

    Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.
    Lee CC, Lin JC, Hwang WL, Kuo YJ, Chen HK, Tai SK, Lin CC, Yang MH., Free PMC Article

    01/19/2019
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