| Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase. | Morc2a variants cause hydroxyl radical-mediated neuropathy and are rescued by restoring GHKL ATPase.
Chung HY, Lee GS, Nam SH, Lee JH, Han JP, Song S, Kim GD, Jung C, Hyeon DY, Hwang D, Choi BO, Yeom SC. | 06/11/2024 |
| Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer. | Novel Insights into the Role of Chromatin Remodeler MORC2 in Cancer.
Chutani N, Ragula S, Syed K, Pakala SB., Free PMC Article | 11/2/2023 |
| Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis. | Alternative polyadenylation reprogramming of MORC2 induced by NUDT21 loss promotes KIRC carcinogenesis.
Tan Y, Zheng T, Su Z, Chen M, Chen S, Zhang R, Wang R, Li K, Na N., Free PMC Article | 09/28/2023 |
| Destabilization of microrchidia family CW-type zinc finger 2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to microtubule-targeting agents. | Destabilization of microrchidia family CW-type zinc finger 2 via the cyclin-dependent kinase 1-chaperone-mediated autophagy pathway promotes mitotic arrest and enhances cancer cellular sensitivity to microtubule-targeting agents.
Hu SY, Qian JX, Yang SY, Andriani L, Liao L, Deng L, Huang MY, Zhang YL, Zhang FL, Shao ZM, Li DQ., Free PMC Article | 03/29/2023 |
| MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration. | MORC2 and MAX contributes to the expression of glycolytic enzymes, breast cancer cell proliferation and migration.
Guddeti RK, Pacharla H, Yellapu NK, Karyala P, Pakala SB. | 02/23/2023 |
| Expanding the phenotypic variability of MORC2 gene mutations: From Charcot-Marie-Tooth disease to late-onset pure motor neuropathy. | Expanding the phenotypic variability of MORC2 gene mutations: From Charcot-Marie-Tooth disease to late-onset pure motor neuropathy.
Jacquier A, Ribault S, Mendes M, Lacoste N, Risson V, Carras J, Latour P, Nadaj-Pakleza A, Stojkovic T, Schaeffer L., Free PMC Article | 12/17/2022 |
| A Cockayne-like phenotype resulting from a de novo variant in MORC2: expanding the phenotype of MORC2-related disorders. | A Cockayne-like phenotype resulting from a de novo variant in MORC2: expanding the phenotype of MORC2-related disorders.
Mirchi A, Derksen A, Tran LT, De Bie I, Nadeau A, Lovett A, Raams A, Vermeulen W, Theil AF, Bernard G. | 11/19/2022 |
| HSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2-driven breast cancer progression. | HSP90 N-terminal inhibitors target oncoprotein MORC2 for autophagic degradation and suppress MORC2-driven breast cancer progression.
Yang F, Sun R, Hou Z, Zhang FL, Xiao Y, Yang YS, Yang SY, Xie YF, Liu YY, Luo C, Liu GY, Shao ZM, Li DQ., Free PMC Article | 05/14/2022 |
| Microrchidia family CWtype zinc finger 2 promotes the proliferation, invasion, migration and epithelialmesenchymal transition of glioma by regulating PTEN/PI3K/AKT signaling via binding to Nmyc downstream regulated gene 1 promoter. | Microrchidia family CW‑type zinc finger 2 promotes the proliferation, invasion, migration and epithelial‑mesenchymal transition of glioma by regulating PTEN/PI3K/AKT signaling via binding to N‑myc downstream regulated gene 1 promoter.
Zhang J, Yang Y, Dong Y, Liu C., Free PMC Article | 03/26/2022 |
| A recurrent MORC2 mutation causes Charcot-Marie-Tooth disease type 2Z. | A recurrent MORC2 mutation causes Charcot-Marie-Tooth disease type 2Z.
Vujovic D, Cornblath DR, Scherer SS., Free PMC Article | 02/19/2022 |
| Charcot-Marie-Tooth disease due to MORC2 mutations in Spain. | Charcot-Marie-Tooth disease due to MORC2 mutations in Spain.
Sivera R, Lupo V, Frasquet M, Argente-Escrig H, Alonso-Pérez J, Díaz-Manera J, Querol L, Del Mar García-Romero M, Ignacio Pascual S, García-Sobrino T, Paradas C, Francisco Vázquez-Costa J, Muelas N, Millet E, Jesús Vílchez J, Espinós C, Sevilla T. | 10/23/2021 |
| Characterization of genotype-phenotype correlation with MORC2 mutated Axonal Charcot-Marie-Tooth disease in a cohort of Chinese patients. | Characterization of genotype-phenotype correlation with MORC2 mutated Axonal Charcot-Marie-Tooth disease in a cohort of Chinese patients.
Duan X, Liu X, Wang G, Gu W, Xu M, Hao Y, Dong M, Sun Q, Sun S, Chen Y, Wang W, Li J, Zhang Y, Cao Z, Fan D, Wang R, Da Y., Free PMC Article | 07/24/2021 |
| The chromatin modifier MORC2 affects glucose metabolism by regulating the expression of lactate dehydrogenase A through a feed forward loop with c-Myc. | The chromatin modifier MORC2 affects glucose metabolism by regulating the expression of lactate dehydrogenase A through a feed forward loop with c-Myc.
Guddeti RK, Thomas L, Kannan A, Karyala P, Pakala SB. | 07/24/2021 |
| De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism. | De Novo Variants in the ATPase Module of MORC2 Cause a Neurodevelopmental Disorder with Growth Retardation and Variable Craniofacial Dysmorphism.
Guillen Sacoto MJ, Tchasovnikarova IA, Torti E, Forster C, Andrew EH, Anselm I, Baranano KW, Briere LC, Cohen JS, Craigen WJ, Cytrynbaum C, Ekhilevitch N, Elrick MJ, Fatemi A, Fraser JL, Gallagher RC, Guerin A, Haynes D, High FA, Inglese CN, Kiss C, Koenig MK, Krier J, Lindstrom K, Marble M, Meddaugh H, Moran ES, Morel CF, Mu W, Muller EA 2nd, Nance J, Natowicz MR, Numis AL, Ostrem B, Pappas J, Stafstrom CE, Streff H, Sweetser DA, Szybowska M, Undiagnosed Diseases Network, Walker MA, Wang W, Weiss K, Weksberg R, Wheeler PG, Yoon G, Kingston RE, Juusola J., Free PMC Article | 10/24/2020 |
| MORC2 regulates C/EBPalpha-mediated cell differentiation via sumoylation. | MORC2 regulates C/EBPα-mediated cell differentiation via sumoylation.
Liu J, Zhang Q, Ruan B, Chen W, Zheng J, Xu B, Jiang P, Miao Z, Li F, Guo JY, Cao L, Wang G., Free PMC Article | 10/3/2020 |
| The MORC2 can form a homodimer through its C-terminal coiled-coil (CC) domain, a process that is enhanced in response to chemotherapeutic drug camptothecin-induced DNA damage. | Dimerization of MORC2 through its C-terminal coiled-coil domain enhances chromatin dynamics and promotes DNA repair.
Xie HY, Zhang TM, Hu SY, Shao ZM, Li DQ., Free PMC Article | 10/3/2020 |
| the findings of this study demonstrated the oncogenic role of MORC2 in cholangiocarcinoma tumorigenesis and metastasis, and clarified an underlying regulatory mechanism mediating MORC2 upregulation | MORC2 promotes cell growth and metastasis in human cholangiocarcinoma and is negatively regulated by miR-186-5p.
Liao G, Liu X, Wu D, Duan F, Xie X, Wen S, Li Y, Li S., Free PMC Article | 07/18/2020 |
| A role for MORC2 in regulating DNA damage-induced G2 checkpoint through NAT10-mediated acetylation. | Acetylation of MORC2 by NAT10 regulates cell-cycle checkpoint control and resistance to DNA-damaging chemotherapy and radiotherapy in breast cancer.
Liu HY, Liu YY, Yang F, Zhang L, Zhang FL, Hu X, Shao ZM, Li DQ., Free PMC Article | 07/11/2020 |
| These changes were more pronounced and accompanied by abnormal axonal morphology, in neurons expressing the MORC2 p.S87L mutation, which is associated with a more severe clinical phenotype. | Characterization of molecular mechanisms underlying the axonal Charcot-Marie-Tooth neuropathy caused by MORC2 mutations.
Sancho P, Bartesaghi L, Miossec O, García-García F, Ramírez-Jiménez L, Siddell A, Åkesson E, Hedlund E, Laššuthová P, Pascual-Pascual SI, Sevilla T, Kennerson M, Lupo V, Chrast R, Espinós C. | 02/8/2020 |
| The findings uncover a previously unrecognized mechanistic link between MORC2 and PARP1 in the regulation of cellular response to DNA damage. | MORC2 regulates DNA damage response through a PARP1-dependent pathway.
Zhang L, Li DQ., Free PMC Article | 12/14/2019 |
| the gain-of-function effect of a single mutation on MORC2 promotes metastasis of triple-negative breast cancer by regulating CD44 splicing mediated by hnRNPM | Cancer-Associated MORC2-Mutant M276I Regulates an hnRNPM-Mediated CD44 Splicing Switch to Promote Invasion and Metastasis in Triple-Negative Breast Cancer.
Zhang FL, Cao JL, Xie HY, Sun R, Yang LF, Shao ZM, Li DQ. | 10/12/2019 |
| MORC2 is widely expressed in human tissues but significantly up-regulated in many cancers, where it is associated with higher histologic grades and poor prognosis. | Aberrant high expression level of MORC2 is a common character in multiple cancers.
Ding QS, Zhang L, Wang BC, Zeng Z, Zou XQ, Cao PB, Zhou GM, Tang M, Wu L, Wu LL, Yu HG, Guo Y, Zhou FX. | 04/13/2019 |
| MORC2 was upregulated in lung cancers relative to adjacent tissues. The results also demonstrated that MORC2 promoted lung cancer tumor growth in vivo. Additionally, MORC2 overexpression stimulated the upregulation of vascular endothelial growth factor (VEGF), driving angiogenesis. MORC2 activated Wnt/beta-catenin signaling in lung cancer cells. | MORC2 Enhances Tumor Growth by Promoting Angiogenesis and Tumor-Associated Macrophage Recruitment via Wnt/β-Catenin in Lung Cancer.
Liu M, Sun X, Shi S. | 01/26/2019 |
| Findings indicate the regulatory mechanism of microrchidia family CW-type zinc finger 2 (MORC2) in downregulating N-myc downstream-regulated gene 1 protein (NDRG1), and suggest MORC2 as a potential therapeutic target for colorectal cancer (CRC). | MORC2 promotes development of an aggressive colorectal cancer phenotype through inhibition of NDRG1.
Liu J, Shao Y, He Y, Ning K, Cui X, Liu F, Wang Z, Li F., Free PMC Article | 01/19/2019 |
| For the first time, to the best of our knowledge, the present study confirmed that MORC2 was a novel oncogene in liver cancer. These results provide useful insight into the mechanism underlying the tumorigenesis and progression of liver cancer, and offers clues into potential novel liver cancer therapies. | MORC2, a novel oncogene, is upregulated in liver cancer and contributes to proliferation, metastasis and chemoresistance.
Pan Z, Ding Q, Guo Q, Guo Y, Wu L, Wu L, Tang M, Yu H, Zhou F., Free PMC Article | 10/6/2018 |