| Midbrain KCC2 downregulation: Implications for stress-related and substance use behaviors. | Midbrain KCC2 downregulation: Implications for stress-related and substance use behaviors.
Pearson AC, Ostroumov A., | 09/19/2024 |
| The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2. | The expression system influences stability, maturation efficiency, and oligomeric properties of the potassium-chloride co-transporter KCC2.
Kok M, Hartnett-Scott K, Happe CL, MacDonald ML, Aizenman E, Brodsky JL., | 03/11/2024 |
| SLC12A5 as a novel potential biomarker of glioblastoma multiforme. | SLC12A5 as a novel potential biomarker of glioblastoma multiforme.
Chen J, Wang H, Deng C, Fei M. | 05/8/2023 |
| SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes. | SLC12A5 promotes hepatocellular carcinoma growth and ferroptosis resistance by inducing ER stress and cystine transport changes.
Tong Q, Qin W, Li ZH, Liu C, Wang ZC, Chu Y, Xu XD., Free PMC Article | 05/4/2023 |
| [Expression of cation chloride cotransporter (NKCC1/KCC2) in brain tissue of children with focal cortical dysplasia type ]. | [Expression of cation chloride cotransporter (NKCC1/KCC2) in brain tissue of children with focal cortical dysplasia type Ⅱ].
Li Y, Li YL, Liu YL, Fu J, Zhang WW, Piao YS. | 11/12/2022 |
| NKCC1 to KCC2 mRNA Ratio in Schizophrenia and Its Psychopathology: a Case-Control Study. | NKCC1 to KCC2 mRNA Ratio in Schizophrenia and Its Psychopathology: a Case-Control Study.
Mohaghghegh H, Ananloo ES, Hadjighasem M, Karimipour M, Hashemizadeh S, Abhari SAA. | 08/20/2022 |
| KCC2 rs2297201 Gene Polymorphism Might be a Predictive Genetic Marker of Febrile Seizures. | KCC2 rs2297201 Gene Polymorphism Might be a Predictive Genetic Marker of Febrile Seizures.
Dimitrijevic S, Jekic B, Cvjeticanin S, Tucovic A, Filipovic T, Novaković I, Ivić B, Nikolic D., Free PMC Article | 04/30/2022 |
| Up-Regulated LncRNA FEZF1-AS1 Promotes the Progression of Cervical Carcinoma Cells via MiR-367-3p/SLC12A5 Signal Axis. | Up-Regulated LncRNA FEZF1-AS1 Promotes the Progression of Cervical Carcinoma Cells via MiR-367-3p/SLC12A5 Signal Axis.
Yang X, Qu Y, Zhang J. | 03/19/2022 |
| Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons. | Developmental dysregulation of excitatory-to-inhibitory GABA-polarity switch may underlie schizophrenia pathology: A monozygotic-twin discordant case analysis in human iPS cell-derived neurons.
Toritsuka M, Yoshino H, Makinodan M, Ikawa D, Kimoto S, Yamamuro K, Okamura K, Akamatsu W, Okada Y, Matsumoto T, Hashimoto K, Ogawa Y, Saito Y, Watanabe K, Aoki C, Takada R, Fukami SI, Hamano-Iwasa K, Okano H, Kishimoto T. | 02/26/2022 |
| Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism. | Right Anterior Theta Hypersynchrony as a Quantitative Measure Associated with Autistic Traits and K-Cl Cotransporter KCC2 Polymorphism.
Aykan S, Puglia MH, Kalaycıoğlu C, Pelphrey KA, Tuncalı T, Nalçacı E. | 01/15/2022 |
| HIV and opiates dysregulate K(+)- Cl(-) cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice. | HIV and opiates dysregulate K(+)- Cl(-) cotransporter 2 (KCC2) to cause GABAergic dysfunction in primary human neurons and Tat-transgenic mice.
Barbour AJ, Hauser KF, McQuiston AR, Knapp PE., Free PMC Article | 07/17/2021 |
| Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on? | Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?
Pozzi D, Rasile M, Corradini I, Matteoli M., Free PMC Article | 07/3/2021 |
| Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons. | Loss of non-canonical KCC2 functions promotes developmental apoptosis of cortical projection neurons.
Mavrovic M, Uvarov P, Delpire E, Vutskits L, Kaila K, Puskarjov M., Free PMC Article | 05/8/2021 |
| Sequence Variation Associated with SLC12A5 Gene Expression Is Linked to Brain Structure and Function in Healthy Adults. | Sequence Variation Associated with SLC12A5 Gene Expression Is Linked to Brain Structure and Function in Healthy Adults.
Gregory MD, Kippenhan JS, Callicott JH, Rubinstein DY, Mattay VS, Coppola R, Berman KF., Free PMC Article | 10/24/2020 |
| KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients. | KCC2 expression levels are reduced in post mortem brain tissue of Rett syndrome patients.
Hinz L, Torrella Barrufet J, Heine VM., Free PMC Article | 09/26/2020 |
| Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction. | Pathogenic potential of human SLC12A5 variants causing KCC2 dysfunction.
Fukuda A, Watanabe M. | 08/22/2020 |
| In this mini-review, KCC2 expression was determined to be increased following active exercise and mechanical stimulation following spinal cord injuries. | Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review.
Lee-Hotta S, Uchiyama Y, Kametaka S. | 04/25/2020 |
| Findings support the conclusion that SLC12A5 protein overexpression could indicate an invasive and/or aggressive phenotype of ovarian carcinoma. | Overexpression of SLC12A5 is associated with tumor progression and poor survival in ovarian carcinoma.
Yang GP, He WP, Tan JF, Yang ZX, Fan RR, Ma NF, Wang FW, Chen L, Li Y, Shen HW, You ZS, Xie D, Yang GF. | 03/7/2020 |
| Our research showed that downregulation of KCC2 and microstructural abnormalities might contribute to the observed refractoriness in temporal lobe epilepsy | Brain microstructural abnormalities correlate with KCC2 downregulation in refractory epilepsy.
Gharaylou Z, Oghabian MA, Azizi Z, Hadjighassem M. | 12/21/2019 |
| Study significantly lower NKCC1 DNA methylation and significantly higher KCC2 DNA methylation levels in patients with juvenile myoclonic epilepsy (JME) compared with the healthy controls. This implies that NKCC1 expression can be higher and KCC2 expression can be reduced in affected people. | Methylation of cation-chloride cotransporters NKCC1 and KCC2 in patients with juvenile myoclonic epilepsy.
Genç F, Kara M, Ünal Y, Uygur Küçükseymen E, Biçer Gömceli Y, Kaynar T, Tosun K, Kutlu G. | 06/15/2019 |
| S31D, T34A, S932A/D, T999A, or T1008A/D of KCC2 abrogated staurosporine mediated stimulation, and S31A, T34D, or S932D abolished NEM-mediated stimulation. | Phosphoregulation of the intracellular termini of K(+)-Cl(-) cotransporter 2 (KCC2) enables flexible control of its activity.
Cordshagen A, Busch W, Winklhofer M, Nothwang HG, Hartmann AM., Free PMC Article | 06/1/2019 |
| the long-time considered "neuron-specific" KCC2 co-transporter is expressed in pancreatic islet beta-cells where it modulates Ca(2+)-dependent insulin secretion. | The neuronal K(+)Cl(-) co-transporter 2 (Slc12a5) modulates insulin secretion.
Kursan S, McMillen TS, Beesetty P, Dias-Junior E, Almutairi MM, Sajib AA, Kozak JA, Aguilar-Bryan L, Di Fulvio M., Free PMC Article | 12/22/2018 |
| These data clearly demonstrated that partially disrupted neuronal Cl(-) extrusion, mediated by two types of differentially impaired KCC2 mutant in an individual, causes epilepsy of infancy with migrating focal seizures. | Impaired neuronal KCC2 function by biallelic SLC12A5 mutations in migrating focal seizures and severe developmental delay.
Saitsu H, Watanabe M, Akita T, Ohba C, Sugai K, Ong WP, Shiraishi H, Yuasa S, Matsumoto H, Beng KT, Saitoh S, Miyatake S, Nakashima M, Miyake N, Kato M, Fukuda A, Matsumoto N., Free PMC Article | 04/21/2018 |
| Study describes the developmental patterns of cation-chloride cotransporters in the human brain from the fetal stage to senescence. Expression of KCC2 and its functionally associated proteins begins in early fetal period. | Developmental Expression Patterns of KCC2 and Functionally Associated Molecules in the Human Brain.
Sedmak G, Jovanov-Milošević N, Puskarjov M, Ulamec M, Krušlin B, Kaila K, Judaš M. | 01/13/2018 |
| The authors show that APP can physically interact with KCC2, a neuron-specific K(+)-Cl(-) cotransporter that is essential for Cl(-) homeostasis and fast GABAergic inhibition. | APP modulates KCC2 expression and function in hippocampal GABAergic inhibition.
Chen M, Wang J, Jiang J, Zheng X, Justice NJ, Wang K, Ran X, Li Y, Huo Q, Zhang J, Li H, Lu N, Wang Y, Zheng H, Long C, Yang L., Free PMC Article | 01/6/2018 |