| Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments. | Identification of SSBP1 as a ferroptosis-related biomarker of glioblastoma based on a novel mitochondria-related gene risk model and in vitro experiments.
Su J, Li Y, Liu Q, Peng G, Qin C, Li Y., Free PMC Article | 10/8/2022 |
| Identification of SSBP1 as a prognostic marker in human lung adenocarcinoma using bioinformatics approaches. | Identification of SSBP1 as a prognostic marker in human lung adenocarcinoma using bioinformatics approaches.
Huang J, Xie ZF. | 03/19/2022 |
| SSBP1-Disease Update: Expanding the Genetic and Clinical Spectrum, Reporting Variable Penetrance and Confirming Recessive Inheritance. | SSBP1-Disease Update: Expanding the Genetic and Clinical Spectrum, Reporting Variable Penetrance and Confirming Recessive Inheritance.
Jurkute N, D'Esposito F, Robson AG, Pitceathly RDS, Cordeiro F, Raymond FL, Moore AT, Michaelides M, Yu-Wai-Man P, Webster AR, Arno G, Genomics England Research Consortium., Free PMC Article | 01/8/2022 |
| Characterization of SSBP1-related optic atrophy and foveopathy. | Characterization of SSBP1-related optic atrophy and foveopathy.
Meunier I, Bocquet B, Defoort-Dhellemmes S, Smirnov V, Arndt C, Picot MC, Dollfus H, Charif M, Audo I, Huguet H, Zanlonghi X, Lenaers G., Free PMC Article | 01/1/2022 |
| De Novo Development of mtDNA Deletion Due to Decreased POLG and SSBP1 Expression in Humans. | De Novo Development of mtDNA Deletion Due to Decreased POLG and SSBP1 Expression in Humans.
Lee Y, Kim T, Lee M, So S, Karagozlu MZ, Seo GH, Choi IH, Lee PCW, Kim CJ, Kang E, Lee BH., Free PMC Article | 07/24/2021 |
| Stimulation of Variant Forms of the Mitochondrial DNA Helicase Twinkle by the Mitochondrial Single-Stranded DNA-Binding Protein. | Stimulation of Variant Forms of the Mitochondrial DNA Helicase Twinkle by the Mitochondrial Single-Stranded DNA-Binding Protein.
Rodrigues APC, Oliveira MT. | 06/19/2021 |
| Optical Tweezers to Investigate the Structure and Energetics of Single-Stranded DNA-Binding Protein-DNA Complexes. | Optical Tweezers to Investigate the Structure and Energetics of Single-Stranded DNA-Binding Protein-DNA Complexes.
Morin JA, Cerrón F, Cao-García FJ, Ibarra B. | 06/19/2021 |
| Analysis of Mitochondrial SSB-DNA Complexes and Their Effects on DNA Polymerase gamma Activity by Electron Microscopy and Enzymatic Assays. | Analysis of Mitochondrial SSB-DNA Complexes and Their Effects on DNA Polymerase γ Activity by Electron Microscopy and Enzymatic Assays.
Bermek O, Ciesielski GL. | 06/19/2021 |
| Consequences of compromised mitochondrial genome integrity. | Consequences of compromised mitochondrial genome integrity.
Gustafson MA, Sullivan ED, Copeland WC., Free PMC Article | 03/28/2021 |
| LncSSBP1 Functions as a Negative Regulator of IL-6 Through Interaction With hnRNPK in Bronchial Epithelial Cells Infected With Talaromyces marneffei. | LncSSBP1 Functions as a Negative Regulator of IL-6 Through Interaction With hnRNPK in Bronchial Epithelial Cells Infected With Talaromyces marneffei.
Li Y, Chen H, Li S, Li Y, Liu G, Bai J, Luo H, Lan X, He Z., Free PMC Article | 12/5/2020 |
| SSBP1 mutations associated with an optic atrophy spectrum disorder. | SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder.
Del Dotto V, Ullah F, Di Meo I, Magini P, Gusic M, Maresca A, Caporali L, Palombo F, Tagliavini F, Baugh EH, Macao B, Szilagyi Z, Peron C, Gustafson MA, Khan K, La Morgia C, Barboni P, Carbonelli M, Valentino ML, Liguori R, Shashi V, Sullivan J, Nagaraj S, El-Dairi M, Iannaccone A, Cutcutache I, Bertini E, Carrozzo R, Emma F, Diomedi-Camassei F, Zanna C, Armstrong M, Page M, Stong N, Boesch S, Kopajtich R, Wortmann S, Sperl W, Davis EE, Copeland WC, Seri M, Falkenberg M, Prokisch H, Katsanis N, Tiranti V, Pippucci T, Carelli V., Free PMC Article | 07/25/2020 |
| mutations in SSBP1 cause a form of dominant optic atrophy frequently accompanied with foveopathy brings insights into mtDNA maintenance disorders. | Dominant mutations in mtDNA maintenance gene SSBP1 cause optic atrophy and foveopathy.
Piro-Mégy C, Sarzi E, Tarrés-Solé A, Péquignot M, Hensen F, Quilès M, Manes G, Chakraborty A, Sénéchal A, Bocquet B, Cazevieille C, Roubertie A, Müller A, Charif M, Goudenège D, Lenaers G, Wilhelm H, Kellner U, Weisschuh N, Wissinger B, Zanlonghi X, Hamel C, Spelbrink JN, Sola M, Delettre C., Free PMC Article | 07/25/2020 |
| findings point toward an essential role of ssbp1 in retinal development. | SSBP1 mutations in dominant optic atrophy with variable retinal degeneration.
Jurkute N, Leu C, Pogoda HM, Arno G, Robson AG, Nürnberg G, Altmüller J, Thiele H, Motameny S, Toliat MR, Powell K, Höhne W, Michaelides M, Webster AR, Moore AT, Hammerschmidt M, Nürnberg P, Yu-Wai-Man P, Votruba M., Free PMC Article | 04/18/2020 |
| These findings suggest that Twinkle is essential for RNA organization in granules, and that mtSSB is involved in the recently proposed GRSF1-mtRNA degradosome pathway, a route suggested to be particularly aimed at degradation of G-quadruplex prone long non-coding mtRNAs. | Mitochondrial RNA granules are critically dependent on mtDNA replication factors Twinkle and mtSSB.
Hensen F, Potter A, van Esveld SL, Tarrés-Solé A, Chakraborty A, Solà M, Spelbrink JN., Free PMC Article | 10/12/2019 |
| Proinflammatory IL-6/STAT3 signaling facilitates mtSSB expression. | Upregulation of mtSSB by interleukin-6 promotes cell growth through mitochondrial biogenesis-mediated telomerase activation in colorectal cancer.
Wang G, Wang Q, Huang Q, Chen Y, Sun X, He L, Zhan L, Guo X, Yin C, Fang Y, He X, Xing J. | 08/10/2019 |
| Single-molecule imaging reveals how SSBP1 interacts with single-stranded DNA replication intermediates during mitochondrial DNA synthesis. | Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein.
Kaur P, Longley MJ, Pan H, Wang H, Copeland WC., Free PMC Article | 07/13/2019 |
| SSBP1 is a novel putative N6-methyldeoxyadenosine (6mA)-binding protein and a mitochondrial DNA (mtDNA) replication factor known to coat the heavy-strand, linking 6mA with the regulation of mtDNA replication. | Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome.
Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS, Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS., Free PMC Articles: PMC6294517, PMC6294517 | 06/29/2019 |
| The hSSB1 plays in the maintenance of DNA genomic stability. | Human single-stranded DNA binding protein 1 (hSSB1, OBFC2B), a critical component of the DNA damage response.
Croft LV, Bolderson E, Adams MN, El-Kamand S, Kariawasam R, Cubeddu L, Gamsjaeger R, Richard DJ. | 06/1/2019 |
| This study described a heterozygous start loss mutation in SSBP1 co-segregating with hearing loss in a maternal pedigree transmitting the m.1555A>G variant. | Heterozygous SSBP1 start loss mutation co-segregates with hearing loss and the m.1555A>G mtDNA variant in a large multigenerational family.
Kullar PJ, Gomez-Duran A, Gammage PA, Garone C, Minczuk M, Golder Z, Wilson J, Montoya J, Häkli S, Kärppä M, Horvath R, Majamaa K, Chinnery PF., Free PMC Article | 03/30/2019 |
| This study identified SSBP1 as a putative N6-methyldeoxyadenosine binding protein. | Single-nucleotide-resolution sequencing of human N6-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome.
Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS, Koh CWQ, Goh YT, Toh JDW, Neo SP, Ng SB, Gunaratne J, Gao YG, Quake SR, Burkholder WF, Goh WSS., Free PMC Articles: PMC6294517, PMC6294517 | 11/13/2018 |
| NEIL1 and homotetrameric mtSSB form a larger ternary complex in presence of DNA, however, the tetrameric form of mtSSB gets disrupted by NEIL1 in the absence of DNA as revealed by the formation of a smaller NEIL1-mtSSBmonomer complex. | The C-terminal tail of the NEIL1 DNA glycosylase interacts with the human mitochondrial single-stranded DNA binding protein.
Sharma N, Chakravarthy S, Longley MJ, Copeland WC, Prakash A., Free PMC Article | 10/6/2018 |
| These results indicated that SSDBP1 may induce cell chemoresistance of cisplatin through promoting DNA repair, resistance-related gene expression, cell proliferation, and inhibiting apoptosis. | UPregulated single-stranded DNA-binding protein 1 induces cell chemoresistance to cisplatin in lung cancer cell lines.
Zhao X, He R, Liu Y, Wu Y, Kang L. | 12/9/2017 |
| Data show that single-stranded DNA binding protein 1 (hSSB1/NABP2/OBFC2B) forms a tetramer and is stabilized by two cysteines (C81 and C99) as well as a subset of charged and hydrophobic residues. | A data-driven structural model of hSSB1 (NABP2/OBFC2B) self-oligomerization.
Touma C, Adams MN, Ashton NW, Mizzi M, El-Kamand S, Richard DJ, Cubeddu L, Gamsjaeger R., Free PMC Article | 10/28/2017 |
| DNA synthesis determines the binding mode of the human mtSSB. | DNA synthesis determines the binding mode of the human mitochondrial single-stranded DNA-binding protein.
Morin JA, Cerrón F, Jarillo J, Beltran-Heredia E, Ciesielski GL, Arias-Gonzalez JR, Kaguni LS, Cao FJ, Ibarra B., Free PMC Article | 10/21/2017 |
| The data presented in this study suggests that while SSBP1 has predominantly been considered in a DNA repair context, it is likely to have roles in many other cellular processes. In particular, the identification of numerous proteins with roles in mRNA metabolism, transcriptional transactions and ribosomal processes, may suggest these as important areas of SSBP1 function. | Novel insight into the composition of human single-stranded DNA-binding protein 1 (hSSB1)-containing protein complexes.
Ashton NW, Loo D, Paquet N, O'Byrne KJ, Richard DJ., Free PMC Article | 09/16/2017 |