| miR-378a-5p represses Barrett's esophagus cells proliferation, migration and invasion through targeting TSPAN8. | miR-378a-5p represses Barrett's esophagus cells proliferation, migration and invasion through targeting TSPAN8.
Xie X, Wei D. | 03/5/2024 |
| TSPAN8 regulates EGFR/AKT pathway to enhance metastasis in gastric cancer. | TSPAN8 regulates EGFR/AKT pathway to enhance metastasis in gastric cancer.
Zhang L, Xu Y, Cai E, Zheng M, Liu L, Wang Q, Li S. | 09/27/2023 |
| The Transmembrane Protein TM4SF3 Interacts With AR and AR-V7 and is Recruited to AR Target Genes. | The Transmembrane Protein TM4SF3 Interacts With AR and AR-V7 and is Recruited to AR Target Genes.
Khatiwada P, Rimal U, Han Z, Malla M, Zhou J, Shemshedini L. | 04/19/2023 |
| Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway to inhibit breast cancer cell migration and invasion in vitro. | Histone demethylase KDM2A suppresses EGF-TSPAN8 pathway to inhibit breast cancer cell migration and invasion in vitro.
Zhang H, Tu Y, Huang B, Xiao J, Xiao J, Wang J, Pei Y, Yang R, Feng J, Li J, Zhang X. | 10/15/2022 |
| TSPAN8 alleviates high glucose-induced apoptosis and autophagy via targeting mTORC2. | TSPAN8 alleviates high glucose-induced apoptosis and autophagy via targeting mTORC2.
Zhuang L, Jin G, Hu X, Yang Q, Pei X, Zhao W. | 09/24/2022 |
| EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription. | EGFR signaling promotes nuclear translocation of plasma membrane protein TSPAN8 to enhance tumor progression via STAT3-mediated transcription.
Lu X, An L, Fan G, Zang L, Huang W, Li J, Liu J, Ge W, Huang Y, Xu J, Du S, Cao Y, Zhou T, Yin H, Yu L, Jiao S, Wang H., Free PMC Article | 04/16/2022 |
| High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake. | High TSPAN8 expression in epithelial cancer cell-derived small extracellular vesicles promote confined diffusion and pronounced uptake.
Wang T, Wang X, Wang H, Li L, Zhang C, Xiang R, Tan X, Li Z, Jiang C, Zheng L, Xiao L, Yue S., Free PMC Article | 03/19/2022 |
| Tetraspanin8 expression predicts an increased metastatic risk and is associated with cancer-related death in human cutaneous melanoma. | Tetraspanin8 expression predicts an increased metastatic risk and is associated with cancer-related death in human cutaneous melanoma.
Berthier-Vergnes O, Barbollat-Boutrand L, Pommier RM, de la Fouchardière A, Combemale P, Grimont M, Lopez-Ramirez N, Caramel J, Dalle S, Perrot JL, Gaudy-Marqueste C, Macagno N, Mansard S, Bouquet F, Masse I., Free PMC Article | 02/26/2022 |
| SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer. | SOX9 is a critical regulator of TSPAN8-mediated metastasis in pancreatic cancer.
Li J, Chen X, Zhu L, Lao Z, Zhou T, Zang L, Ge W, Jiang M, Xu J, Cao Y, Du S, Yu Y, Fan G, Wang H., Free PMC Article | 01/8/2022 |
| Tspan8 Is Highly Expressed in Clear Cell Renal Cell Carcinoma and Indicates Poor Prognosis. | Tspan8 Is Highly Expressed in Clear Cell Renal Cell Carcinoma and Indicates Poor Prognosis.
Tang Y, Xie J, Chen Y, Zhang T, Zhuo H, Chen J, Yang P, Cui Q, Zhao L, Li L. | 06/5/2021 |
| Silencing of long non-coding RNA SOX21-AS1 inhibits lung adenocarcinoma invasion and migration by impairing TSPAN8 via transcription factor GATA6. | Silencing of long non-coding RNA SOX21-AS1 inhibits lung adenocarcinoma invasion and migration by impairing TSPAN8 via transcription factor GATA6.
Xu Y, Wu H, Wu L, Xu L, Li J, Wang Q, Pu X. | 04/24/2021 |
| Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma. | Identification of CD318, TSPAN8 and CD66c as target candidates for CAR T cell based immunotherapy of pancreatic adenocarcinoma.
Schäfer D, Tomiuk S, Küster LN, Rawashdeh WA, Henze J, Tischler-Höhle G, Agorku DJ, Brauner J, Linnartz C, Lock D, Kaiser A, Herbel C, Eckardt D, Lamorte M, Lenhard D, Schüler J, Ströbel P, Missbach-Guentner J, Pinkert-Leetsch D, Alves F, Bosio A, Hardt O., Free PMC Article | 03/20/2021 |
| TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy. | TSPAN8 as a Novel Emerging Therapeutic Target in Cancer for Monoclonal Antibody Therapy.
Heo K, Lee S., Free PMC Article | 03/20/2021 |
| Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation. | Extracellular vesicle tetraspanin-8 level predicts distant metastasis in non-small cell lung cancer after concurrent chemoradiation.
Liu Y, Fan J, Xu T, Ahmadinejad N, Hess K, Lin SH, Zhang J, Liu X, Liu L, Ning B, Liao Z, Hu TY., Free PMC Article | 11/21/2020 |
| TSPAN8 directly interacted ss-catenin and enhanced its protein expression, which is necessary for TSPAN8-mediated effects on colorectal cancer stemness. | A Positive Tetraspanin 8 (TSPAN8)/β-Catenin Regulatory Loop Enhances the Stemness of Colorectal Cancer Cells.
Zhan Z, Zhong L, Feng M, Guo Y., Free PMC Article | 06/6/2020 |
| Findings show the presence of Tspan8 in breast cancer primary lesion and metastases and indicate its role as a regulator of cell behaviour and extracellular vesicle release in breast cancer. Tspan8 and p120-catenin were co-immunoprecipitated, indicating that they may interact with each other. | Tspan8 is expressed in breast cancer and regulates E-cadherin/catenin signalling and metastasis accompanied by increased circulating extracellular vesicles.
Voglstaetter M, Thomsen AR, Nouvel J, Koch A, Jank P, Navarro EG, Gainey-Schleicher T, Khanduri R, Groß A, Rossner F, Blaue C, Franz CM, Veil M, Puetz G, Hippe A, Dindorf J, Kashef J, Thiele W, Homey B, Greco C, Boucheix C, Baur A, Erbes T, Waller CF, Follo M, Hossein G, Sers C, Sleeman J, Nazarenko I., Free PMC Article | 04/18/2020 |
| High TSPAN8 mRNA expression in the colorectal cancer.LSD1 up-regulated TSPAN8 expression and reduced H3K9me2 occupancy on the TSPAN8 promoter in the colorectal cancer cells. | TSPAN8 promotes colorectal cancer cell growth and migration in LSD1-dependent manner.
Zhang HS, Liu HY, Zhou Z, Sun HL, Liu MY. | 02/8/2020 |
| TSPAN8 is a part of a positive feedback loop and plays role in the invasive properties required for tumor progression and melanoma dissemination. | Tspan8-β-catenin positive feedback loop promotes melanoma invasion.
El Kharbili M, Agaësse G, Barbollat-Boutrand L, Pommier RM, de la Fouchardière A, Larue L, Caramel J, Puisieux A, Berthier-Vergnes O, Masse I. | 12/7/2019 |
| These findings reveal a molecular basis of TSPAN8-enhanced Sonic Hedgehog signaling and highlight a role for TSPAN8 in promoting cancer stemness. | TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.
Zhu R, Gires O, Zhu L, Liu J, Li J, Yang H, Ju G, Huang J, Ge W, Chen Y, Lu Z, Wang H., Free PMC Article | 08/24/2019 |
| High TSPAN8 expression is associated with Drug Resistance in Colorectal Cancer. | Comprehensive Genetic Search to Clarify the Molecular Mechanism of Drug Resistance Identifies ASCL2-LEF1/TSPAN8 Axis in Colorectal Cancer.
Tanaka T, Kojima K, Yokota K, Tanaka Y, Ooizumi Y, Ishii S, Nishizawa N, Yokoi K, Ushiku H, Kikuchi M, Kojo K, Minatani N, Katoh H, Sato T, Nakamura T, Sawanobori M, Watanabe M, Yamashita K. | 08/10/2019 |
| miR-324-5p inhibited gastric cancer cell survival by targeting TSPAN8 expression. | MiR-324-5p reduces viability and induces apoptosis in gastric cancer cells through modulating TSPAN8.
Lin H, Zhou AJ, Zhang JY, Liu SF, Gu JX. | 01/19/2019 |
| TSPAN8 mediated Wnt/beta-catenin pathway through binding to NOTCH2. The role of TSPAN8 in the drug resistance of gastric cancer. | Quantitative proteomics analysis of the role of tetraspanin-8 in the drug resistance of gastric cancer.
Li L, Yang D, Cui D, Li Y, Nie Z, Wang J, Liang L. | 08/11/2018 |
| these data point to a crucial role of Co-029 in the modulation of colon cancer cell motility which could be related to the protumoral effect reported for this tetraspanin. Among surface molecules able to mediate Co-029 function, E-cadherin, EGFR and CD44 appear as likely candidates. | Multi-factorial modulation of colorectal carcinoma cells motility - partial coordination by the tetraspanin Co-029/tspan8.
Zhu Y, Ailane N, Sala-Valdés M, Haghighi-Rad F, Billard M, Nguyen V, Saffroy R, Lemoine A, Rubinstein E, Boucheix C, Greco C., Free PMC Article | 03/10/2018 |
| Single nucleotide polymorphism in TSPAN8 gene is associated with pathogenesis of bipolar disorder. | The regulation of tetraspanin 8 gene expression-A potential new mechanism in the pathogenesis of bipolar disorder.
Schartner C, Scholz CJ, Weber H, Post A, Freudenberg F, Grünewald L, Reif A. | 02/10/2018 |
| Tetraspanin-8 has a role in promoting hepatocellular carcinoma metastasis by increasing ADAM12m expression | Tetraspanin-8 promotes hepatocellular carcinoma metastasis by increasing ADAM12m expression.
Fang T, Lin J, Wang Y, Chen G, Huang J, Chen J, Zhao Y, Sun R, Liang C, Liu B., Free PMC Article | 01/13/2018 |