CD3G CD3 gamma subunit of T-cell receptor complex [Homo sapiens (human)] - Gene

Summary

Official Symbol: CD3Gprovided by HGNC
Official Full Name: CD3 gamma subunit of T-cell receptor complexprovided by HGNC
Primary source: HGNC:HGNC:1675
See related: Ensembl:ENSG00000160654 MIM:186740; AllianceGenome:HGNC:1675
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: T3G; IMD17; CD3GAMMA; CD3-GAMMA
Summary: The protein encoded by this gene is the CD3-gamma polypeptide, which together with CD3-epsilon, -delta and -zeta, and the T-cell receptor alpha/beta and gamma/delta heterodimers, forms the T-cell receptor-CD3 complex. This complex plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. The genes encoding the epsilon, gamma and delta polypeptides are located in the same cluster on chromosome 11. Defects in this gene are associated with T cell immunodeficiency. [provided by RefSeq, Jul 2008]
Expression: Biased expression in lymph node (RPKM 14.5), appendix (RPKM 7.1) and 9 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11q23.3

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (118344344..118355161)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (118360702..118371519)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (118215059..118225876)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
Title: Immune-Related Molecules CD3G and FERMT3: Novel Biomarkers Associated with Sepsis.
These data demonstrate that the T-cell repertoire of patients with CD3G mutations is characterized by a molecular signature that may contribute to the increased rate of autoimmunity associated with this condition.
Title: Patients with CD3G mutations reveal a role for human CD3γ in T(reg) diversity and suppressive function.
CD3 showed a positive correlation with tryptase and microvascular density, while multiple regression analysis efficaciously predicted microvascular density depending on CD3 and tryptase as predictors, supporting a complex interplay between these cells in sustaining tumor angiogenesis in Diffuse large B cell lymphoma patients.
Title: T cells, mast cells and microvascular density in diffuse large B cell lymphoma.
The study identifies an important role of the CD3gamma dileucine motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling.
Title: Fine-tuning of T-cell development by the CD3γ di-leucine-based TCR-sorting motif.
HER2/CD3 BsAb efficiently inhibited the growth of breast cancer tissue by activating and inducing the proliferation of tumor tissue infiltrating lymphocytes.
Title: Fully human HER2/cluster of differentiation 3 bispecific antibody triggers potent and specific cytotoxicity of T lymphocytes against breast cancer.
The docking site for CD3 subunits on the T Cell receptor beta chain has been identified by solution NMR.
Title: Identification of the Docking Site for CD3 on the T Cell Receptor β Chain by Solution NMR.
Low cord blood Foxp3/CD3gamma mRNA ratios are highly predictive for early allergy development.
Title: Low cord blood Foxp3/CD3γ mRNA ratios: a marker of increased risk for allergy development.
Data indicate that the high CD68/CD3 ratio identifies a bad prognosis group among muscle-invasive urothelial carcinoma (UC). cases.
Title: Infiltration of CD3⁺ and CD68⁺ cells in bladder cancer is subtype specific and affects the outcome of patients with muscle-invasive tumors.
Case Report: T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15;q32) [TCRgamma-TCL1A translocation] confirmed by FISH.
Title: T-cell lymphoblastic leukemia/lymphoma with t(7;14)(p15;q32) [TCRγ-TCL1A translocation]: a case report and a review of the literature.
The results suggest that CD3G should be studied as a candidate gene for autoimmunity and that CD3gamma deficiency should be considered among other primary immunodeficiencies with predominantly autoimmune manifestations.
Title: CD3G gene defects in familial autoimmune thyroiditis.

Submit: New GeneRIF Correction See all GeneRIFs (42)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Combined immunodeficiency due to CD3gamma deficiency MedGen: C3810107 OMIM: 615607 GeneReviews: Not available	Compare labs
Immunodeficiency due to defect in CD3-gamma MedGen: C1861297 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 inhibits CD3-induced Lck activation and cellular tyrosine phosphorylation, particularly of phosphoinositide-specific phospholipase C-gamma-1	PubMed
	env	Binding of HIV-1 gp120 to the CD4 receptor molecule results in co-stimulation of CD3-induced T cell activation	PubMed
	env	HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells	PubMed
	env	HIV-1 gp120 induces CD4 association with lymphocyte surface molecules CD3, CD11a, CD27, CD45RA, CD45RB, CD45RO, CD49d, CD38, CD26, CD59, CD95 and class I MHC molecules	PubMed
	env	Treatment of CD4+ T cells with HIV-1 gp120 significantly increases CD4 association with CD3, CD45RA, CD45RB, CD59, CD38, CD26 and HLA class I, and decreases that with CD45RC	PubMed
Envelope transmembrane glycoprotein gp41	env	Gp41 TMD co-localizes with the CD3-TCR complex and inhibits T-cell activation induced by antibodies to CD3	PubMed
	env	HIV-1 gp41 peptide (amino acids 581-597) inhibits lymphoproliferation stimulated via the T-cell-activation molecules CD3, CD2, and CD28, as well as via direct stimulation mediated by phorbol ester combined with ionomycin	PubMed
	env	A synthetic peptide containing residues 581-597 from HIV-1 gp41 inhibits protein kinase C (pkC)-mediated phosphorylation of the CD3 gamma-chain in intact cells and directly inhibits partially purified pkC	PubMed
Nef	nef	HIV-1 nef alleles from the great majority of primate lentiviruses, including HIV-2, downregulate TCR-CD3 from infected T cells and thereby block their responsiveness to activation	PubMed
	nef	Expression of HIV-1 Tat and/or HIV-1 Nef in the absence of HIV-1 Rev leads to downregulation of CD3-gamma gene transcripts and TCR/CD3 surface density	PubMed
	nef	Inhibition of T-cell migration of HIV-1 Nef expressing cells by CD3 stimulation results from the inhibition of surface expression of CXCR4	PubMed
	nef	HIV-1 Nef upregulates IL2 secretion when Jurkat cells are stimulated with both CD3 and CD28	PubMed
	nef	HIV-1 Nef interacts with CD3 in living cells	PubMed
Pr55(Gag)	gag	Monocyte-derived macrophages selectively capture and engulf HIV-1-infected CD4+ T cells as HIV-1 Gag interacts with CD3 and Caspase 3 markers, leading to efficient macrophage infection	PubMed
	gag	CD3/28-treated resting CD4+ T cells produce more HIV-1 Gag protein than untreated cells	PubMed
	gag	Interferon-gamma can counteract the inhibitory effect of peptides based on the Capsid protein of HIV-1 Gag on antibody response to SRC	PubMed
	gag	Peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation	PubMed
	gag	Synthetic peptides corresponding to amino acids 218-238 of the Capsid protein of HIV-1 Gag have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex	PubMed
Tat	tat	HIV-1 Tat interacts with CD3 and CD28 to co-stimulate IL-2 and IL-8 expression	PubMed
Vpu	vpu	HIV-1 Vpu interacts with CD3 in living cells	PubMed
capsid	gag	Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to SRC	PubMed
	gag	Peptides corresponding to amino acids 218-238 of HIV-1 Capsid inhibited anti-CD3-induced lymphoproliferation but did not directly affect anti-CD2 activation	PubMed
	gag	Synthetic peptides corresponding to amino acids 218-238 of HIV-1 Capsid have been shown to inhibit in a dose dependent manner the induction of a specific antibody response to the sheep red cell (SRC) antigen through the T3-Ti complex	PubMed
matrix	gag	HIV-1 MA co-localizes with CD3 marker protein in monocyte-derived macrophages cocultured with HIV-1-infected primary CD4+ T-cells	PubMed
nucleocapsid	gag	HIV-1 NC upregulates CD3G antigen, gamma in HEK 293T cells	PubMed

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D8S2279 (e-PCR)
- UniSTS:473907

NoName (e-PCR)
- UniSTS:482375

GDB:197879 (e-PCR)
- UniSTS:155984

D1S1425 (e-PCR)
- UniSTS:149621

D11S4362 (e-PCR)
- UniSTS:64885

NoName (e-PCR)
- UniSTS:489646

RH80031 (e-PCR)
- UniSTS:91103

Clone Names

FLJ17620, FLJ17664, FLJ79544, FLJ94613, MGC138597

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables T cell receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables identical protein binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor complex adaptor activity	NAS Non-traceable Author Statement more info	PubMed
enables transmembrane signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transmembrane signaling receptor activity	IC Inferred by Curator more info	PubMed
enables transmembrane signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in T cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in T cell receptor signaling pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in adaptive immune response	NAS Non-traceable Author Statement more info	PubMed
involved_in alpha-beta T cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	IC Inferred by Curator more info	PubMed
involved_in cell surface receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment or maintenance of cell polarity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in gamma-delta T cell activation	NAS Non-traceable Author Statement more info	PubMed
involved_in positive thymic T cell selection	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein-containing complex assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of lymphocyte apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of alpha-beta T cell receptor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of alpha-beta T cell receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of alpha-beta T cell receptor complex	IPI Inferred from Physical Interaction more info	PubMed
part_of alpha-beta T cell receptor complex	ISS Inferred from Sequence or Structural Similarity more info
located_in clathrin-coated endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in cytosol	IDA Inferred from Direct Assay more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
part_of gamma-delta T cell receptor complex	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	NAS Non-traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: T-cell surface glycoprotein CD3 gamma chain

Names: CD3g antigen, gamma polypeptide (TiT3 complex); CD3g molecule, epsilon (CD3-TCR complex); CD3g molecule, gamma (CD3-TCR complex); T-cell antigen receptor complex, gamma subunit of T3; T-cell receptor T3 gamma chain

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_007566.1 RefSeqGene

Range

5001..14439

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_39

mRNA and Protein(s)

NM_000073.3 → NP_000064.1 T-cell surface glycoprotein CD3 gamma chain precursor

See identical proteins and their annotated locations for NP_000064.1

Status: REVIEWED

Source sequence(s)

AK310622, AP001582, DB116263, DC378393, X04145

Consensus CDS

CCDS8395.1

UniProtKB/Swiss-Prot

P09693, Q2HIZ6

UniProtKB/TrEMBL

B0YIY5, Q53FH3

Related

ENSP00000431445.2, ENST00000532917.3

Conserved Domains (3) summary

pfam02189
Location:157 → 176

ITAM; Immunoreceptor tyrosine-based activation motif

pfam16680
Location:39 → 115

Ig_4; T-cell surface glycoprotein CD3 delta chain

cd07691
Location:42 → 46

IgC1_CD3_gamma_delta; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000011.10 Reference GRCh38.p14 Primary Assembly

Range

118344344..118355161

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006718941.4 → XP_006719004.1 T-cell surface glycoprotein CD3 gamma chain isoform X1

See identical proteins and their annotated locations for XP_006719004.1

UniProtKB/Swiss-Prot

P09693, Q2HIZ6

UniProtKB/TrEMBL

B0YIY5, Q53FH3

Conserved Domains (3) summary

pfam02189
Location:157 → 176

ITAM; Immunoreceptor tyrosine-based activation motif

pfam16680
Location:39 → 115

Ig_4; T-cell surface glycoprotein CD3 delta chain

cd07691
Location:42 → 46

IgC1_CD3_gamma_delta; Ig strand B [structural motif]
XM_005271724.5 → XP_005271781.1 T-cell surface glycoprotein CD3 gamma chain isoform X2

Conserved Domains (1) summary

pfam16680
Location:40 → 106

Ig_4; T-cell surface glycoprotein CD3 delta chain

Alternate T2T-CHM13v2.0

Genomic

NC_060935.1 Alternate T2T-CHM13v2.0

Range

118360702..118371519

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054370495.1 → XP_054226470.1 T-cell surface glycoprotein CD3 gamma chain isoform X1

UniProtKB/Swiss-Prot

P09693, Q2HIZ6

UniProtKB/TrEMBL

B0YIY5