TRIP6 thyroid hormone receptor interactor 6 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TRIP6provided by HGNC
Official Full Name: thyroid hormone receptor interactor 6provided by HGNC
Primary source: HGNC:HGNC:12311
See related: Ensembl:ENSG00000087077 MIM:602933; AllianceGenome:HGNC:12311
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: OIP1; OIP-1; ZRP-1; TRIP-6; TRIP6i2
Summary: This gene is a member of the zyxin family and encodes a protein with three LIM zinc-binding domains. This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma membrane occurs in a lysophosphatidic acid (LPA)-dependent manner and it regulates LPA-induced cell migration. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in endometrium (RPKM 26.6), kidney (RPKM 24.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q22.1

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (100867387..100873454)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (102107487..102113558)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (100465009..100471076)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TRIP6 a potential diagnostic marker for colorectal cancer with glycolysis and immune infiltration association.
Title: TRIP6 a potential diagnostic marker for colorectal cancer with glycolysis and immune infiltration association.
ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines.
Title: ABCB1 Amplicon Contains Cyclic AMP Response Element-Driven TRIP6 Gene in Taxane-Resistant MCF-7 Breast Cancer Sublines.
The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.
Title: The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes.
TRIP6 accelerates the proliferation and invasion of cervical cancer by upregulating oncogenic YAP signaling.
Title: TRIP6 accelerates the proliferation and invasion of cervical cancer by upregulating oncogenic YAP signaling.
TRIP6 promotes tumorigenic capability through regulating FOXC1 in hepatocellular carcinoma.
Title: TRIP6 promotes tumorigenic capability through regulating FOXC1 in hepatocellular carcinoma.
MiR-7 directly inhibited TRIP6 expression in colorectal cancer.TRIP6 is involved in important colorectal cancer cellular processes, including cell migration, invasion, proliferation, differentiation and survival.Colorectal cancer patients with higher expression of TRIP6 had poor a poorer prognosis.
Title: TRIP6, as a target of miR-7, regulates the proliferation and metastasis of colorectal cancer cells.
High TRIP6 expression is associated with Cell Proliferation, Cell Migration and Invasion in Endometrial Carcinoma.
Title: Targeting Thyroid Receptor Interacting Protein 6 by MicroRNA-589-5p Inhibits Cell Proliferation, Migration, and Invasion in Endometrial Carcinoma.
TRIP6 acts as an intermediary connecting tension monitoring at adherens junctions to Hippo signaling, which has implications for how tension contributes to growth of organs and tissues during development, tissue repair during injury and to pathological conditions such as cancer.
Title: TRIP6 inhibits Hippo signaling in response to tension at adherens junctions.
Taken together, these findings showed that TRIP6 plays an important role in promoting HCC cells proliferation and may serve as a novel prognostic biomarker and therapeutic target in HCC.
Title: TRIP6 promotes cell proliferation in hepatocellular carcinoma via suppression of FOXO3a.
TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma
Title: Overexpression of TRIP6 promotes tumor proliferation and reverses cell adhesion-mediated drug resistance (CAM-DR) via regulating nuclear p27(Kip1) expression in non-Hodgkin's lymphoma.

Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH101934 (e-PCR)
- UniSTS:96269

D7S2888 (e-PCR)
- UniSTS:73808

A002D09 (e-PCR)
- UniSTS:57698

SHGC-30159 (e-PCR)
- UniSTS:37246

Clone Names

MGC3837, MGC4423, MGC10556, MGC10558, MGC29959

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables interleukin-1 receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclear thyroid hormone receptor binding	NAS Non-traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chordate embryonic development	IEA Inferred from Electronic Annotation more info
involved_in focal adhesion assembly	NAS Non-traceable Author Statement more info	PubMed
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of non-canonical NF-kappaB signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info
located_in focal adhesion	HDA more info	PubMed
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info
is_active_in stress fiber	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: thyroid receptor-interacting protein 6

Names: OPA-interacting protein 1; TR-interacting protein 6; thyroid hormone receptor interacting protein 6; zyxin related protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_003302.3 → NP_003293.2 thyroid receptor-interacting protein 6

See identical proteins and their annotated locations for NP_003293.2

Status: REVIEWED

Source sequence(s)

BC004999, BM800083

Consensus CDS

CCDS5708.1

UniProtKB/Swiss-Prot

A4D2E7, F2ZC07, F2ZC08, O15170, O15275, Q15654, Q9BTB2, Q9BUE5, Q9BXP3, Q9UNT4

UniProtKB/TrEMBL

F2ZC06

Related

ENSP00000200457.4, ENST00000200457.9

Conserved Domains (4) summary

cd09350
Location:279 → 332

LIM1_TRIP6; The first LIM domain of Thyroid receptor-interacting protein 6 (TRIP6)

cd09357
Location:399 → 461

LIM3_Zyxin_like; The third LIM domain of Zyxin-like family

cl02475
Location:339 → 398

LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

cl26464
Location:8 → 251

Atrophin-1; Atrophin-1 family