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    EIF3C eukaryotic translation initiation factor 3 subunit C [ Homo sapiens (human) ]

    Gene ID: 8663, updated on 28-Oct-2024

    Summary

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    Official Symbol
    EIF3Cprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit Cprovided by HGNC
    Primary source
    HGNC:HGNC:3279
    See related
    Ensembl:ENSG00000184110 MIM:603916; AllianceGenome:HGNC:3279
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF3CL; EIF3S8; eIF3-p110
    Summary
    Enables ribosome binding activity. Contributes to translation initiation factor activity. Involved in positive regulation of translation and translational initiation. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Oct 2024]
    Expression
    Ubiquitous expression in ovary (RPKM 96.4), thyroid (RPKM 93.0) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See EIF3C in Genome Data Viewer
    Location:
    16p11.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28688558..28735730)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28969279..29016311)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28699879..28747051)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene nuclear pore complex interacting protein family member B8 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28677654-28678567 Neighboring gene small nucleolar RNA U13 Neighboring gene cell division cycle 37 pseudogene 1 Neighboring gene microRNA 6862-2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:28742791-28743343 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28751627-28752170 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28752171-28752713 Neighboring gene uncharacterized LOC124903761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28770347-28770847 Neighboring gene pro-apoptotic WT1 regulator pseudogene 2 Neighboring gene nuclear pore complex interacting protein family member B9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer. Hu J, et al. Cancer Invest, 2019. PMID 31181967
    2. Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells. Wen F, et al. Biosci Rep, 2019 Aug 30. PMID 31316002, Free PMC Article
    3. Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma. Fan M, et al. Int J Oncol, 2019 Dec. PMID 31638200
    4. Effect of siRNA-mediated knockdown of eIF3c gene on survival of colon cancer cells. Song N, et al. J Zhejiang Univ Sci B, 2013 Jun. PMID 23733421, Free PMC Article
    5. Eukaryotic initiation factor 3C silencing inhibits cell proliferation and promotes apoptosis in human glioma. Hao J, et al. Oncol Rep, 2015 Jun. PMID 25823503

    See all (197) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Complement factor H attenuates TNF-alpha-induced inflammation by upregulating EIF3C in rheumatoid arthritis.
      Title: Complement factor H attenuates TNF-α-induced inflammation by upregulating EIF3C in rheumatoid arthritis.
    2. circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.
      Title: circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.
    3. Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
      Title: Human oncoprotein 5MP suppresses general and repeat-associated non-AUG translation via eIF3 by a common mechanism.
    4. ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C.
      Title: ZNF280A promotes lung adenocarcinoma development by regulating the expression of EIF3C.
    5. Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
      Title: Eukaryotic initiation factor 3, subunit C silencing inhibits cell proliferation and promotes apoptosis in human ovarian cancer cells.
    6. circ_0067934 promotes cervical cancer progression via miR-545/EIF3C axis.
      Title: Overexpressed circ_0067934 acts as an oncogene to facilitate cervical cancer progression via the miR-545/EIF3C axis.
    7. eIF3C expression was upregulated in renal cell carcinoma (RCC) tissues and cell lines. Depletion of eIF3C reduced tumor cell proliferation and arrested them at the G1 stage, thus promoting their apoptosis in vitro. Depletion of eIF3C also inhibited the formation and growth of tumor cell xenografts in nude mice. Study demonstrated that upregulated eIF3C expression contributed to the development and progression of RCC.
      Title: Upregulated expression of eIF3C is associated with malignant behavior in renal cell carcinoma.
    8. Whereas the eIF3c knockdown reduces it, downregulation of eIF3k or eIF3l increases mRNA recruitment, suggesting that the latter subunits possess a regulatory potential. Altogether this study provides new insights into the role of human eIF3 in the initial assembly steps of the translational machinery
      Title: Adapted formaldehyde gradient cross-linking protocol implicates human eIF3d and eIF3c, k and l subunits in the 43S and 48S pre-initiation complex assembly, respectively.
    9. EIF3C overexpression was correlated to age and tumor stage in prostate cancer patients and indicated poor survival. The proliferation, migration, and invasiveness of PC3 cells were all inhibited after EIF3C knockdown. Phosphorylation level of PI3K and Akt and total NF-kappaB and Myc decreased after EIF3C knockdown. Therefore, EIF3C at least partially regulates the activity of PI3K/Akt/NF-kappaB signaling pathway in PC3...
      Title: The Prognostic Significance of EIF3C Gene during the Tumorigenesis of Prostate Cancer.
    10. In EIF3C-positive tumors, 32 out of 42 showed significantly higher frequencies of high grade group by immunoreactivity.
      Title: Decreasing Eukaryotic Initiation Factor 3C (EIF3C) Suppresses Proliferation and Stimulates Apoptosis in Breast Cancer Cell Lines Through Mammalian Target of Rapamycin (mTOR) Pathway.
    Submit: New GeneRIF Correction See all GeneRIFs (16)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common variants at five new loci associated with early-onset inflammatory bowel disease.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
    retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit C (EIF3C) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ53378, FLJ54400, FLJ54404, FLJ55450, FLJ55750, FLJ78287, MGC189737, MGC189744

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables ribosome binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to translation initiation factor activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of mRNA binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in positive regulation of translation IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in translational initiation IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of eukaryotic translation initiation factor 3 complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit C
    Names
    cell migration-inducing protein 17
    eukaryotic translation initiation factor 3 subunit 8
    eukaryotic translation initiation factor 3, subunit 8 (110kD)
    eukaryotic translation initiation factor 3, subunit 8, 110kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001037808.2 → NP_001032897.1  eukaryotic translation initiation factor 3 subunit C isoform a

      See identical proteins and their annotated locations for NP_001032897.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AC145285, AL045958, BC001571, BC071705, DC341554
      Consensus CDS
      CCDS10638.1
      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
      UniProtKB/TrEMBL
      A1KYQ7
      Related
      ENSP00000378953.1, ENST00000395587.5
      Conserved Domains (2) summary
      smart00088
      Location:778 → 866
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam05470
      Location:29 → 705
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    2. NM_001199142.1 → NP_001186071.1  eukaryotic translation initiation factor 3 subunit C isoform a

      See identical proteins and their annotated locations for NP_001186071.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AA679705, AK292155
      Consensus CDS
      CCDS10638.1
      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
      UniProtKB/TrEMBL
      A1KYQ7
      Related
      ENSP00000457963.1, ENST00000566501.5
      Conserved Domains (2) summary
      smart00088
      Location:778 → 866
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam05470
      Location:29 → 705
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    3. NM_001267574.2 → NP_001254503.1  eukaryotic translation initiation factor 3 subunit C isoform a

      See identical proteins and their annotated locations for NP_001254503.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      AC145285, AK000739, AL045958, BC001571, DC341554
      Consensus CDS
      CCDS10638.1
      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
      UniProtKB/TrEMBL
      A1KYQ7
      Related
      ENSP00000457418.1, ENST00000566866.5
      Conserved Domains (2) summary
      smart00088
      Location:778 → 866
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam05470
      Location:29 → 705
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    4. NM_001286478.1 → NP_001273407.1  eukaryotic translation initiation factor 3 subunit C isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) uses an alternate in-frame splice junction at the 5' end of an exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a.
      Source sequence(s)
      AC145285, AK303790, BC001571, DC341554
      Consensus CDS
      CCDS66993.1
      UniProtKB/TrEMBL
      A1KYQ7
      Related
      ENSP00000456416.1, ENST00000564243.5
      Conserved Domains (2) summary
      smart00753
      Location:768 → 856
      PAM; PCI/PINT associated module
      pfam05470
      Location:29 → 695
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    5. NM_003752.5 → NP_003743.1  eukaryotic translation initiation factor 3 subunit C isoform a

      See identical proteins and their annotated locations for NP_003743.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) is the predominant transcript. Variants 1-4 encode the same isoform (a).
      Source sequence(s)
      BC001571, DC341554
      Consensus CDS
      CCDS10638.1
      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
      UniProtKB/TrEMBL
      A1KYQ7
      Related
      ENSP00000332604.7, ENST00000331666.11
      Conserved Domains (2) summary
      smart00088
      Location:778 → 866
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam05470
      Location:29 → 705
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      28688558..28735730
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434828.1 → XP_047290784.1  eukaryotic translation initiation factor 3 subunit C isoform X1

      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

    2. XM_047434827.1 → XP_047290783.1  eukaryotic translation initiation factor 3 subunit C isoform X1

      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

    3. XM_017023814.3 → XP_016879303.1  eukaryotic translation initiation factor 3 subunit C isoform X2

      UniProtKB/TrEMBL
      A1KYQ7

    4. XM_047434829.1 → XP_047290785.1  eukaryotic translation initiation factor 3 subunit C isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      28969279..29016311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054314249.1 → XP_054170224.1  eukaryotic translation initiation factor 3 subunit C isoform X1

      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98

    2. XM_054314250.1 → XP_054170225.1  eukaryotic translation initiation factor 3 subunit C isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99613.1 GenPept UniProtKB/Swiss-Prot:Q99613

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