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    WBP11 WW domain binding protein 11 [ Homo sapiens (human) ]

    Gene ID: 51729, updated on 3-Nov-2024

    Summary

    Official Symbol
    WBP11provided by HGNC
    Official Full Name
    WW domain binding protein 11provided by HGNC
    Primary source
    HGNC:HGNC:16461
    See related
    Ensembl:ENSG00000084463 MIM:618083; AllianceGenome:HGNC:16461
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BUG13; FAP90; NPWBP; SIPP1; VCTRL; CFAP90; VCTERL; WBP-11; PPP1R165
    Summary
    This gene encodes a nuclear protein, which colocalizes with mRNA splicing factors and intermediate filament-containing perinuclear networks. This protein has 95% amino acid sequence identity to the mouse Wbp11 protein. It contains two proline-rich regions that bind to the WW domain of Npw38, a nuclear protein, and thus this protein is also called Npw38-binding protein NpwBP. The Npw38-NpwBP complex may function as a component of an mRNA factory in the nucleus. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 48.6), bone marrow (RPKM 38.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See WBP11 in Genome Data Viewer
    Location:
    12p12.3
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (14784582..14803478, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (14661939..14680843, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (14937516..14956412, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:14923287-14923883 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:14926759-14927676 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:14927677-14928593 Neighboring gene H4 histone 16 Neighboring gene H2A.J histone Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4276 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6057 Neighboring gene chromosome 12 open reading frame 60 Neighboring gene single-pass membrane protein with coiled-coil domains 3 Neighboring gene ADP-ribosyltransferase 4 (inactive) (Dombrock blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    Associated conditions

    Description Tests
    Vertebral, cardiac, tracheoesophageal, renal, and limb defects
    MedGen: C5543189 OMIM: 619227 GeneReviews: Not available
    not available

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • DKFZp779M1063

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in RNA splicing  
    involved_in mRNA processing  
    involved_in rRNA processing  
    Component Evidence Code Pubs
    located_in cytosol  
    located_in intracellular membrane-bounded organelle  
    located_in nucleoplasm  
    located_in nucleoplasm  
    located_in nucleus PubMed 

    General protein information

    Preferred Names
    WW domain-binding protein 11
    Names
    Npw38-binding protein NpwBP
    SH3 domain-binding protein SNP70
    protein phosphatase 1, regulatory subunit 165
    splicing factor that interacts with PQBP-1 and PP1
    splicing factor, PQBP1 and PP1 interacting

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016312.3NP_057396.1  WW domain-binding protein 11

      See identical proteins and their annotated locations for NP_057396.1

      Status: REVIEWED

      Source sequence(s)
      AC007655, AC010168
      Consensus CDS
      CCDS8666.1
      UniProtKB/Swiss-Prot
      Q96AY8, Q9Y2W2
      UniProtKB/TrEMBL
      B4DMD3, B4DY34
      Related
      ENSP00000261167.2, ENST00000261167.7
      Conserved Domains (1) summary
      pfam09429
      Location:1292
      Wbp11; WW domain binding protein 11

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      14784582..14803478 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      14661939..14680843 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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