involved in vacuolar protein sorting; required for localization and trafficking of the CPY sorting receptor; Vps8p is a membrane-associated hydrophilic protein which contains a C-terminal cysteine-rich region that conforms to the H2 variant of the RING finger Zn2+ binding motif.; Null mutant is viable, missorts and secretes vacuolar hydrolases, overexpression of VPS21 partially suppresses vps8 null
Stress-seventy subfamily A; Heat shock protein of HSP70 family, cytoplasmic; Null mutant is viable, temperature sensitive; ssa1 ssa2 ssa4 strains are inviable; an intact copy of SSA3 regulated by the constitutive SSA2 promoter is capable of rescuing the inviability of an ssa1 ssa2 ssa4 strain
dispensable for mitosis, but required for a normal mutation rate, required for premeiotic DNA synthesis, recombination, meiosis I, meiosis II, glycogen degradation and spores; Null mutant is viable, sporulation defective
Mitochondrial outer membrane protein involved in mitochondrial morphology and inheritance; Null mutant has short actin cables. Point mutants exhibit giant, spherical mitochondria and are defective for mitochondrial inheritance.
protein phosphatase 2A regulatory subunit A; Null mutant is viable, defective in cytokinesis at reduced temperatures, defective in transcription by RNA polymerase III at elevated temperatures; nocodazole sensitive and exhibits phenotypes of previously identified kinetochore/spindle checkpoint mutants
