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| Status |
Public on Jan 23, 2019 |
| Title |
Sex differences in gene regulation in the dorsal root ganglion after nerve injury |
| Organism |
Rattus norvegicus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Pain is a subjective experience derived from complex interactions among biological, environmental, and psychosocial pathways. Sex differences in pain sensitivity and chronic pain prevalence are well established. However, the molecular causes underlying these sex dimorphisms are poorly understood particularly with regard to the role of the peripheral nervous system. Here we sought to identify shared and distinct gene networks functioning in the peripheral nervous systems that may contribute to sex differences of pain after nerve injury. We performed RNA-seq on dorsal root ganglia following chronic constriction injury of the sciatic nerve in male and female rats. Analysis from paired naive and injured tissues showed that 1456 genes were differentially expressed between sexes. Appreciating sex-related gene expression differences and similarities in neuropathic pain models may help to improve the translational relevance to clinical populations and efficacy of clinical trials of this major health issue.
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| |
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| Overall design |
examination of gene expression naïve and injured, male and female rats
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| |
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| Contributor(s) |
Stephens KE, Taverna SD |
| Citation(s) |
30782122 |
| Submission date |
Jun 16, 2017 |
| Last update date |
Mar 12, 2019 |
| Contact name |
Sean Taverna |
| E-mail(s) |
staverna@jhmi.edu
|
| Organization name |
Johns Hopkins University
|
| Department |
Pharmacology & Molecular Sciences
|
| Street address |
855 N Wolfe St
|
| City |
Baltimore |
| State/province |
MD |
| ZIP/Postal code |
21205 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL18694 |
Illumina HiSeq 2500 (Rattus norvegicus) |
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| Samples (8)
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| Relations |
| BioProject |
PRJNA390760 |
| SRA |
SRP109547 |
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