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| Status |
Public on Jan 03, 2009 |
| Title |
Gene expression data from murine liver samples comparing hormone sensitive lipase (HSL) knockout mice vs. wildtype mice |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
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| Summary |
HSL is a key enzyme in in the mobilization of fatty acids from the triglyceride stores of white adipose tissue. In addition, it is expressed in mice liver. In the present microarray study, changes in the transcript profile of murine liver samples due to global HSL knockout were investigated.
Keywords: genetic modification
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| Overall design |
Genetic modification to analyze the impact of a general knockout of the HSL gene on liver metabolism.
HSL knockout (ko) mice versus wildtype (wt) mice. Mice fed a normal diet (ND) versus mice fed a high fat diet (FD) for 6 months. Equal amounts of liver samples from six mice were pooled and total RNA was extracted, except for HSL-null mice on FD were only 4 livers were pooled.
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| Contributor(s) |
Fernandez C, Holm C |
| Citation(s) |
18664600 |
| |
| Submission date |
Jan 04, 2008 |
| Last update date |
Feb 18, 2018 |
| Contact name |
Céline Fernandez |
| E-mail(s) |
Celine.Fernandez@med.lu.se
|
| Phone |
+46 46 222 9772
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| Fax |
+46 46 222 4022
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| Organization name |
Medical Faculty, Lund University
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| Department |
Experimental Medical Science
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| Lab |
Molecular Endocrinology Group
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| Street address |
BMC C11
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| City |
Lund |
| ZIP/Postal code |
221 84 |
| Country |
Sweden |
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| Platforms (1) |
| GPL81 |
[MG_U74Av2] Affymetrix Murine Genome U74A Version 2 Array |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA108173 |
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