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| Status |
Public on Oct 04, 2018 |
| Title |
Transcriptomic and genomic profiling of early-stage ovarian carcinomas associated with histotype and overall survival [ARRAY] |
| Organism |
Homo sapiens |
| Experiment type |
Genome variation profiling by SNP array
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| Summary |
Ovarian cancer is the most lethal gynecological malignancy in the western world. Despite recent efforts to characterize ovarian cancer using molecular profiling, few targeted treatment options are currently available. Here, we examined genetic variants, fusion transcripts, SNP genotyping, and gene expression patterns for early-stage (I, II) ovarian carcinomas (n=96) in relation to clinicopathological characteristics and clinical outcome, thereby identifying novel genetic features of ovarian carcinomas. Furthermore, mutation frequencies of specific genetic variants and/or their gene expression patterns were associated with histotype and overall survival, e.g. SLC28A2 (mucinous ovarian carcinoma histotype), ARCN1 (low expression in 0-2 year survival group), and tumor suppressor MTUS1 (mutation status and overall survival). The long non-coding RNA MALAT1 was identified as a highly promiscuous fusion transcript in ovarian carcinoma. Moreover, gene expression deregulation for 23 genes was associated with tumor aggressiveness. Taken together, the novel biomarkers identified here may improve ovarian carcinoma subclassification and patient stratification according to histotype and overall survival.
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| Overall design |
Genome-wide SNP genotyping was performed for nine early-stage primary invasive ovarian carcinomas.
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| Contributor(s) |
Engqvist H, Parris TZ, Werner Rönnerman E, Söderberg EM, Biermann J, Mateoiu C, Sundfeldt K, Kovács A, Karlsson P, Helou K |
| Citation(s) |
30416686, 31533654 |
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| Submission date |
Jul 10, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Hanna Engqvist |
| E-mail(s) |
hanna.engqvist@gu.se
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| Organization name |
University of Gothenburg
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| Lab |
Sahlgrenska Cancer Center
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| Street address |
Medicinaregatan 1G
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| City |
Gothenburg |
| ZIP/Postal code |
41390 |
| Country |
Sweden |
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| Platforms (1) |
| GPL23668 |
Illumina Human Infinium Omni2.5-8 v1.3 BeadChip |
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| Samples (9)
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| This SubSeries is part of SuperSeries: |
| GSE101109 |
Transcriptomic and genomic profiling of early-stage ovarian carcinomas associated with histotype and overall survival |
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| Relations |
| BioProject |
PRJNA393723 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE101107_RAW.tar |
1.1 Gb |
(http)(custom) |
TAR (of IDAT, TXT) |
| Processed data provided as supplementary file |
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