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| Status |
Public on Jul 19, 2017 |
| Title |
Whole genome expression analysis of clinical bone metastasis samples |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Total RNA from clinical bone metastasis samples were analyzed using whole genome expression bead arrays and the Illumina platform with the objective to identify molecular subgroups of potential clinical relevance.
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| Overall design |
Fresh-frozen bone metastasis samples from men with castration-resistant prostate cancer (CRPC, n = 40), untreated prostate cancer (n = 8) or other malignancies (n = 12) were characterized using whole-genome expression profiling followed by multivariate principal component analysis (PCA) and functional enrichment analysis. The CRPC samples were defined as androgen receptor (AR) driven or non-AR driven based on expression of AR and AR-regulated genes (AR activity), please see Ylitalo et al, Eur Urol. 2017 May;71(5):776-787 (PMID 27497761) for further description.
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| Contributor(s) |
Bovinder Ylitalo E, Thysell E, Jernberg E, Lundholm M, Crnalic S, Egevad L, Stattin P, Widmark A, Bergh A, Wikström P |
| Citation(s) |
27497761, 34193246 |
| |
| Submission date |
Jul 19, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Pernilla Wikström |
| E-mail(s) |
pernilla.wikstrom@umu.se
|
| Phone |
+46907853752
|
| Organization name |
Umeå University
|
| Department |
Medical biosciences, Pathology
|
| Street address |
Department of Medical biosciences, Buildning 6M, 2nd floor
|
| City |
UMEÅ |
| ZIP/Postal code |
901 85 |
| Country |
Sweden |
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| Platforms (1) |
| GPL10558 |
Illumina HumanHT-12 V4.0 expression beadchip |
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| Samples (60)
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| Relations |
| BioProject |
PRJNA394982 |
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