|
| Status |
Public on Aug 22, 2017 |
| Title |
VHL/HIF2a axis alters transcriptomic profiles in ccRCC |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
VHL loss is the most common genetic alteration event in ccRCC. VHL loss stabilizes hypoxia-inducible factor-2 alpha (HIF2a). We compared the changes in transcriptomics profiles after VHL restoration or HIF2a siRNA knockdown in 786-O cells.
|
| |
|
| Overall design |
RNA-seq profiles of ccRCC cell line 786-O with and without wild-type VHL restoration, with non-targeting control or pooled siRNA against HIF2a
|
| |
|
| Contributor(s) |
Yao X, Tan P |
| Citation(s) |
28893800 |
| |
| Submission date |
Jul 31, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Xiaosai Yao |
| E-mail(s) |
xiaosai.yao@gmail.com, yao.xiaosai@gene.com
|
| Phone |
+65 68088271
|
| Organization name |
Genome Institute of Singapore
|
| Street address |
60 Biopolis Street, Genome, #02-01
|
| City |
Singapore |
| ZIP/Postal code |
138672 |
| Country |
Singapore |
| |
|
| Platforms (1) |
| GPL11154 |
Illumina HiSeq 2000 (Homo sapiens) |
|
| Samples (4)
|
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| This SubSeries is part of SuperSeries: |
| GSE86095 |
VHL deficiency drives enhancer activation of oncogenes in clear cell renal cell carcinoma |
|
| Relations |
| BioProject |
PRJNA396577 |
| SRA |
SRP114458 |
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