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| Status |
Public on Dec 26, 2018 |
| Title |
Expression data from human umbilical vein endothelial cells(HUVECs) undergoning normal, hypoxia/reoxygenation-induced injury and Inulin-type oligosaccharides administration |
| Platform organism |
Homo sapiens |
| Sample organism |
Homo |
| Experiment type |
Expression profiling by array
|
| Summary |
To characterize the differentially expressed genes in HUVECs between normal, hypoxia/reoxygenation-induced injury and Inulin-type oligosaccharides administration. Performing the Affymetrix Human Transcriptome Array 2.0 (HTA2.0, n=3) assay demonstrated that Hex5 exposure up-regulated genes enriched in cell cycle progression, DNA replication and repair, ubiquitin-mediated proteolysis, apoptosis, MAPK, and the IP3K-mTOR signaling pathway. Our results suggested that inulin-type oligosaccharides from the root of M.officinalis may protect against H/R-induced tissue injury
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| Overall design |
The Affymetrix Human Transcriptome Array 2.0 (HTA2.0) assay suggested that Inulin-type oligosaccharides extracting from Morinda officinalis protect human umbilical vein endothelial cells from hypoxia/reoxygenation-induced injury. Each sample had 3 biological replicates
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| Contributor(s) |
Xuexiang C, Guoqing F |
| Citation(s) |
31047086 |
| Submission date |
Sep 12, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Xuexiang Cha |
| E-mail(s) |
chaxuexiang@zzu.edu.cn
|
| Phone |
13837179446
|
| Organization name |
Zhengzhou University
|
| Department |
Basic Medical Science
|
| Lab |
Pharmacology
|
| Street address |
Kexue Avenue 100
|
| City |
Zhengzhou |
| State/province |
Henan |
| ZIP/Postal code |
450001 |
| Country |
China |
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| Platforms (1) |
| GPL17586 |
[HTA-2_0] Affymetrix Human Transcriptome Array 2.0 [transcript (gene) version] |
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| Samples (9)
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| Relations |
| BioProject |
PRJNA406955 |
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