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Status |
Public on Oct 03, 2017 |
Title |
Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
|
Summary |
Maternal hyperglycemia increases the risk of CHD and is further sensitized by haploinsufficiency of Notch1 supporting a gene-environment interaction model. To gain insights into chromatin accessible status by which hyperglycemia affects molecular pathways regulating cardiac development, we performed ATAC-seq on embryonic AV cushion mesenchymal cells maintained in normal and high glucose.
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Overall design |
ATAC sequencing of mouse embryonic atrioventricular mesenchymal cells in the setting of normoglycemia and hyperglycemia
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Contributor(s) |
Basu M, LaHaye S, Jiao K, Garg V |
Citation(s) |
29046480 |
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Submission date |
Oct 02, 2017 |
Last update date |
Jul 25, 2021 |
Contact name |
Vidu Garg |
E-mail(s) |
vidu.garg@nationwidechildrens.org
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Phone |
614-355-5710
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Organization name |
Research Institute at Nationwide Children's Hospital
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Department |
Cardiovascular Research
|
Lab |
Vidu Garg
|
Street address |
700 Children's Drive WB4239
|
City |
Columbus |
State/province |
OH |
ZIP/Postal code |
43205 |
Country |
USA |
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Platforms (1) |
GPL13112 |
Illumina HiSeq 2000 (Mus musculus) |
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Samples (6)
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Relations |
BioProject |
PRJNA412907 |
SRA |
SRP119270 |