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Series GSE104520 Query DataSets for GSE104520
Status Public on Oct 03, 2017
Title Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary Maternal hyperglycemia increases the risk of CHD and is further sensitized by haploinsufficiency of Notch1 supporting a gene-environment interaction model. To gain insights into chromatin accessible status by which hyperglycemia affects molecular pathways regulating cardiac development, we performed ATAC-seq on embryonic AV cushion mesenchymal cells maintained in normal and high glucose.
 
Overall design ATAC sequencing of mouse embryonic atrioventricular mesenchymal cells in the setting of normoglycemia and hyperglycemia
 
Contributor(s) Basu M, LaHaye S, Jiao K, Garg V
Citation(s) 29046480
Submission date Oct 02, 2017
Last update date Jul 25, 2021
Contact name Vidu Garg
E-mail(s) vidu.garg@nationwidechildrens.org
Phone 614-355-5710
Organization name Research Institute at Nationwide Children's Hospital
Department Cardiovascular Research
Lab Vidu Garg
Street address 700 Children's Drive WB4239
City Columbus
State/province OH
ZIP/Postal code 43205
Country USA
 
Platforms (1)
GPL13112 Illumina HiSeq 2000 (Mus musculus)
Samples (6)
GSM2802799 NG1
GSM2802800 NG2
GSM2802801 NG3
Relations
BioProject PRJNA412907
SRA SRP119270

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE104520_RAW.tar 2.8 Mb (http)(custom) TAR (of NARROWPEAK)
SRA Run SelectorHelp
Raw data are available in SRA
Processed data provided as supplementary file

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