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| Status |
Public on Mar 22, 2023 |
| Title |
Chromatin Profiling of RT112 bladder cancer cell line |
| Organism |
Homo sapiens |
| Experiment type |
Genome binding/occupancy profiling by high throughput sequencing
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| Summary |
Tumor progression is related to both genetic and epigenetic alterations. Until relatively recently, epigenetic changes were thought to target single genes only but we show that in Bladder tumours, epigenetic changes can affect whole chromosomal regions, resulting in the silencing of all the genes within those regions. This phenomenon is probably very general, and has been described in bladder, colon, breast and prostate cancers. In order to investigate epigenetic landscape and potential alterations in bladder, we established the chromatin profiling of RT112 cell line by ChIPseq for the following marks : H3K4me3, H3K9ac, H3K27me3, H3K9me3, H3K27ac, H3K4me1, and CTCF.
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| Overall design |
Examination of 6 different histone modifications and one insulator factor in RT112 cell line
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| Contributor(s) |
Neyret-Kahn H, Ye T, Radvanyi F, Davidson I |
| Citation(s) |
36944729 |
| |
| Submission date |
Oct 11, 2017 |
| Last update date |
Jun 21, 2023 |
| Contact name |
Tao YE |
| Organization name |
IGBMC (CNRS/INSERM/UDS)
|
| Street address |
1 rue Laurent Fries
|
| City |
Illkirch |
| ZIP/Postal code |
67404 |
| Country |
France |
| |
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| Platforms (1) |
| GPL16791 |
Illumina HiSeq 2500 (Homo sapiens) |
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| Samples (15)
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| This SubSeries is part of SuperSeries: |
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| Relations |
| BioProject |
PRJNA413887 |
| SRA |
SRP119731 |
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