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| Status |
Public on Dec 26, 2018 |
| Title |
Tumor suppressor miRNA inhibits medulloblastoma growth and sensitizes vincristine and radiation response by inducing spindle defects and DNA damage |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
|
| Summary |
Medulloblastoma (MB) is the most common malignant brain tumor in children. Despite recent improvements in overall survival, only a modest percentage of patients survive high-risk MB. The devastating side effects of radiation and chemotherapy substantially reduce qualify of life for surviving patients. We identified a novel tumor suppressor miRNA that sensitizes both ionizing radiation and vincristine responses in medulloblastoma. To understand the mechanism by which the tumor suppressor miR-584-5p may act as a tumor suppressor and therapy sensitizer, we performed microarray analysis in D425Med and D458Med medulloblastoma cells transfected with scrambled (miR-NC) or miR-584-5p mimic (miR-584-5p).
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| |
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| Overall design |
miRNA knockdown experiment with two MB cell lines
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| |
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| Contributor(s) |
Abdelfattah N, Panneerdoss S, Chen Y, Rao M |
| Citation(s) |
30382096 |
| |
| Submission date |
Oct 17, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
Yidong Chen |
| E-mail(s) |
cheny8@uthscsa.edu
|
| Phone |
2105629163
|
| Organization name |
UT Health Science Center at San Antonio
|
| Department |
Population Health Sciences
|
| Street address |
8403 Floyd Curl Drive, MSC 7784
|
| City |
San Antonio |
| State/province |
Texas |
| ZIP/Postal code |
78229 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL10904 |
Illumina HumanHT-12 V4.0 expression beadchip (gene symbol) |
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| Samples (4)
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| Relations |
| BioProject |
PRJNA414531 |
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