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| Status |
Public on May 01, 2018 |
| Title |
Suppression of regulatory T cells by autoreactive CD8+ T effector cells in rheumatoid arthritis |
| Organism |
Homo sapiens |
| Experiment type |
Other
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| Summary |
Autoreactive CD8+ T effector (eff) cells specific to vimentin, actin cytoplasmic 1, or non-muscle myosin heavy chain 9 epitopes, evade regulatory T (Treg) cells in patients with rheumatoid arthritis undergoing worsening disease and who would become non-responders to tumor necrosis factor (TNF)-α inhibitor therapy, in contrast to autoreactive CD8+ T naïve (N) cells that are efficiently controlled by Treg cells in healthy individuals or patients who would become responders.
Gene expression analysis revealed that the autoreactive CD8+ TN cell subset is comprised of a heterogeneous population of cells at various stages of development in healthy individuals or patients. Mechanistically, the production of TNF-α by CD8+ TN cells and the killing activity by CD8+ Teff cells in response to the relevant self-antigens influence the endorsement or suppression of Treg function, respectively. These data provide evidence of a previously undescribed role of such mechanisms in the progression and therapy of a prototypical human autoimmune disease, such as rheumatoid arthritis.
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| Overall design |
Nanostring gene expression analysis was performed on RNA extracted from Naïve (N) and effector (Eff) CD8+ T lymphocytes, specific for apoptotic epitopes, sorted from patients with rheumatoid arthritis (P) and from healthy donors (HDs), and 26 samples were analysed: 5 N from HDs, 4 Eff from HDs, 9 N from P and 8 Eff from P.
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| Contributor(s) |
Martire C, Cammarata I, Citro A, Raimondo D, Carone C, Peruzzi G, Cerboni C, Santoni A, Sideny J, Sette A, Paroli M, Caccavale R, Milanetti E, Riminucci M, Piconese S, Scrivo R, Valesini G, Cariani E, Barnaba V |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
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| Submission date |
Oct 19, 2017 |
| Last update date |
Jul 25, 2021 |
| Contact name |
domenico raimondo |
| E-mail(s) |
domenico.raimondo@uniroma1.it
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| Organization name |
Sapienza University of Rome
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| Department |
Molecular Medicine
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| Lab |
Stem cells
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| Street address |
Viale Regina Elena 324
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| City |
Rome |
| ZIP/Postal code |
00161 |
| Country |
Italy |
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| Platforms (1) |
| GPL24155 |
nCounter SC Human Immunology V2 |
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| Samples (26)
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| Relations |
| BioProject |
PRJNA414984 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE105162_RAW.tar |
180.0 Kb |
(http)(custom) |
TAR (of RCC) |
| Processed data included within Sample table |
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