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| Status |
Public on Jul 01, 2018 |
| Title |
Common lymphoid progenitor derivation of plasmacytoid dendritic cells is mediated by Bcl11a |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
|
| Summary |
Plasmacytoid dendritic cells (pDC) specialize in type I interferon production to coordinate innate and adaptive immunity. We identify two pDC subsets in vivo, evaluate their genome-wide expression, and demonstrate a developmental requirement for Bcl11a to provide insight into this enigmatic cell type.
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| Overall design |
We separated plasmacytoid dendritic cells that were derived from either the common lymphoid progenitor or the common myeloid progenitor by flow cytometry, collected RNA, and ran RNA-seq.
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| Contributor(s) |
Dekker JD |
| Citation missing |
Has this study been published? Please login to update or notify GEO. |
| Submission date |
Oct 23, 2017 |
| Last update date |
May 15, 2019 |
| Contact name |
Joseph D Dekker |
| E-mail(s) |
joedekker@gmail.com
|
| Phone |
5054637855
|
| Organization name |
University of Texas at Austin
|
| Department |
Molecular Biosciences
|
| Street address |
2506 Speedway Blvd, NMS 1.264
|
| City |
Austin |
| State/province |
TX |
| ZIP/Postal code |
78712 |
| Country |
USA |
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| Platforms (1) |
| GPL21103 |
Illumina HiSeq 4000 (Mus musculus) |
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| Samples (6)
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| Relations |
| BioProject |
PRJNA415465 |
| SRA |
SRP120999 |
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